Cancer Immune Therapy Edited by G. Stuhler and P. Walden ...

XIV Contents
14.2.2.1 Cancer-specific antibodies 290
14.2.2.2 Ligands and receptors recognition units 290
14.2.3. Pre-Clinical Experimental Models 292
14.2.4. Clinical Trials 293
14.3 Conclusions and Perspectives 294
Acknowledgments 295
References 295
15 Bone Marrow Transplantation for Immune Therapy 299
Fabio Ciceri and Claudio Bordignon
15.1 Introduction 299
15.2 Graft-versus-Host (GvH) Reactions 299
15.3 Graft-versus-Tumor (GvT) Effect 301
15.4 Donor Lymphocyte Infusions (DLIs) 301
15.5 Complications of DLI: GvHD and Marrow Aplasia 303
15.6 Strategies to reduce GvHD while preserving GvT 303
15.7 The Suicide Gene Strategy 304
15.8 HSV-tk Lymphocyte Add-backsafter Haploidentical Transplantation 306
15.9 Reduced Intensity versus Conventional Conditioning Regimens 307
References 307
16 Immunocytokines: Versatile Molecules for Biotherapy
of Malignant Disease 311
Holger N. Lode, Rong Xiang, Jçrgen C. Becker, Andreas G. Niethammer,
F. James Primus, Stephen D. Gillies and Ralph A. Reisfeld
16.1 Introduction 311
16.1.1 Immunocytokines 311
16.1.2 Construction of Immunocytokines 312
16.1.3 Binding and Cytokine Activity of IL-2 Immunocytokines 313
16.2 Treatment of Tumor Metastases with Immunocytokines 313
16.2.1 Colorectal Carcinoma 313
16.2.2 Long-lived Tumor-Protective Immunity is Boosted by Non-curative Doses
of huKS1/4±IL-2 Immunocytokine 316
16.2.3 Carcinoembryonic Antigen (CEA)-based DNA Vaccines for Colon
Carcinoma Boosted by IL-2 Immunocytokine 319
16.2.4 T Cell-mediated Protective Immunity against Colon Carcinoma Induced
by a DNA Vaccine encoding CEA and CD40 Ligand Trimer
(CD40LT) 322
16.3 Non-small Cell Lung Carcinoma 324
16.3.1 Boost of a CEA-based DNA Vaccine by the huKS1/4±IL-2 Immunocytokine
324
16.4 Prostate Carcinoma 327
16.4.1 Suppression of Human Prostate Cancer Metastases by an IL-2
Immunocytokine 327
16.5 Melanoma 330