- Page 1 and 2:
Université Montpellier I UFR Méd
- Page 3 and 4:
Un grand merci à tous mes collabor
- Page 5 and 6:
TitleBreast cancer and tumoral micr
- Page 7 and 8:
Cancer du sein et micro-environneme
- Page 9 and 10:
C. PRESENTATION DU TRAVAIL DE THESE
- Page 11 and 12:
But de la thèseLa cathepsine-D (ca
- Page 13 and 14:
I. Le tissu adipeux1) Généralité
- Page 15 and 16:
(Adenosine triphosphate). Cette pro
- Page 18 and 19:
Cette synthèse de novo a lieu dans
- Page 20 and 21:
ABFigure 6 : Schéma de la oxydati
- Page 22 and 23:
d. Ladipocyte : une cellule sécré
- Page 24 and 25:
3) Ladipogenèsea. Les différentes
- Page 26 and 27:
. Les facteurs de transcriptionLa d
- Page 28 and 29:
Lexpression de C/EBP est quant à e
- Page 30 and 31:
adipeux. Les analyses histologiques
- Page 32 and 33:
adipocyteFigure 10 : Schéma repré
- Page 34 and 35:
II. La cathepsine-D1) Synthèse, ma
- Page 36 and 37:
les cath-B et L, en une forme matur
- Page 38 and 39:
Il existe deux RM6P : le RM6P/IGFII
- Page 40 and 41:
2) Fonctions de la cath-Da. Dans la
- Page 42 and 43:
. Dans les pathologiesEn plus de se
- Page 44 and 45:
c. Rôles et mécanismes daction da
- Page 46 and 47:
carcinome de prostate serait respon
- Page 48 and 49:
La cath-D joue donc un rôle import
- Page 50 and 51:
Une fois le marquage des peptides e
- Page 52 and 53:
Afin de réaliser ce projet, nous a
- Page 54 and 55:
III. Le récepteur LRP11) Organisat
- Page 56 and 57:
2) Trafic intra-cellulaireComme le
- Page 58 and 59:
LRP1αLRP1Membrane associatedprotea
- Page 60 and 61:
Tableau 3 : Ligands connus du LRP1(
- Page 62 and 63:
I. Etude du rôle de la cathepsine
- Page 64 and 65:
Cathepsin-D, a key protease in brea
- Page 66 and 67:
IntroductionConsumption of meals ri
- Page 68 and 69:
(Fig. 1A, panel a). This differenti
- Page 70 and 71:
differentiated adipocyte (Fig. 4B).
- Page 72 and 73:
DiscussionOur results demonstrate t
- Page 74 and 75:
from normal and peri-al breast adip
- Page 76 and 77:
mouse RS9 (sens 5CGGCCCGGGAGCTGTTGA
- Page 78 and 79:
agreement of local ethic committee.
- Page 80 and 81:
Statistical analysis. Results are e
- Page 82 and 83:
Loncarek J, Freiss G, Vignon F and
- Page 84 and 85:
Aa3000 *b4000*B8000**cath-D mRNA(ar
- Page 86 and 87:
ABcath-D mRNA(ratio RS9)PPARg mRNA(
- Page 88 and 89:
A D3 D7 D14D0BaD0 D3 D7 D14D0 D3 D7
- Page 90 and 91:
AshLucshcath-DF442A C34 C37 A4 D10c
- Page 92 and 93:
AF442-AC34C37A4D10BF442-AC34C37A4D1
- Page 94 and 95:
II. Etude du rôle du LRP1 dans les
- Page 96 and 97:
2) Article 2:LRP1 receptor controls
- Page 98 and 99:
LRP1, Adipogenesis, Obesityrelative
- Page 100 and 101:
LRP1, Adipogenesis, ObesityFigure 3
- Page 102 and 103:
LRP1, Adipogenesis, ObesityFigure 5
- Page 104 and 105:
LRP1, Adipogenesis, ObesitySome ins
- Page 106 and 107:
LRP1, Adipogenesis, ObesityLipolysi
- Page 108 and 109:
CONCLUSIONLa cathepsine D (cath-D)
- Page 110 and 111:
la souris obèses. Enfin, linhibiti
- Page 112 and 113: carcinogénique sont encore mal con
- Page 114 and 115: Ce travail de thèse a étudié, po
- Page 116 and 117: REFERENCESAhima, R. S. (2006). Adip
- Page 118 and 119: implicates them as antigen presenti
- Page 120 and 121: Cataldo, A. M., Barnett, J. L., Ber
- Page 122 and 123: Folkman, J. (2003). Fundamental con
- Page 124 and 125: Hofmann, S. M., Zhou, L., Perez-Til
- Page 126 and 127: Langin, D. (2006a). Adipose tissue
- Page 128 and 129: Ludwig, T., Ovitt, C. E., Bauer, U.
- Page 130 and 131: Nirde, P., Derocq, D., Maynadier, M
- Page 132 and 133: Rozanov, D. V., Hahn-Dantona, E., S
- Page 134 and 135: Taleb, S., Cancello, R., Clement, K
- Page 136 and 137: Xiao, Y., Junfeng, H., Tianhong, L.
- Page 138 and 139: F. ANNEXE98
- Page 140 and 141: Cathepsin D is a new ligand for ext
- Page 142 and 143: INTRODUCTIONLysosomal aspartic prot
- Page 144 and 145: pcDNA3.1(+)Myc-tagged LRP1b into pc
- Page 146 and 147: (Protein refolding kit, Novagen) fo
- Page 148 and 149: anti-mouse-gold (Aurion). Sections
- Page 150 and 151: not secrete detectable levels of pr
- Page 152 and 153: using cath-D-/- MEF transfected wit
- Page 154 and 155: co-culture outgrowth assays with ca
- Page 156 and 157: REFERENCES1. Vignon, F., Capony, F.
- Page 158 and 159: steps in vivo: proliferation, angio
- Page 160 and 161: 28. Laurent-Matha, V., Lucas, A., H
- Page 164 and 165: Figure 1. Cath-D interacts with the
- Page 166 and 167: Figure 2. Cath-D binds to residues
- Page 168 and 169: Figure 3. Cath-D interacts with LRP
- Page 170 and 171: Figure 5. Silencing LRP1 in cath-D
- Page 172 and 173: Figure 1. Cath-D interacts with the
- Page 174 and 175: Figure 6. LRP1 is the receptor medi
- Page 176 and 177: Beaujouin, Figure Sup. 2cath-D-/-ME
- Page 178: RésuméLaspartyl protéase catheps