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“
"Our
results indicate that cannabinoid receptors are important in the pathology of
AD and that cannabinoids succeed in preventing the neurodegenerative process
occurring in the disease."
— Prevention of Alzheimer's Disease Pathology by Cannabinoids:
Neuroprotection Mediated by Blockade of Microglial Activation [5] ”
I uppföljande studier bekräftar forskare att administrering av bl.a den ickepsykoaktiva cannabinoiden
cannabidiol (CBD) också skapar en lindring av minnesförlusten och har antiinflammatoriska
egenskaper.
“
"CBD
is able to modulate microglial cell function in vitro and induce beneficial effects
in an in vivo model of AD. Given that CBD lacks psychoactivity, it may represent a
novel therapeutic approach for this neurological disease."
— Cannabidiol and other cannabinoids reduce microglial activation in vitro
and in vivo: relevance to Alzheimer's disease [6] ”
“
"The
results of the present study confirm in vivo anti-inflammatory actions of CBD,
emphasizing the importance of this compound as a novel promising pharmacological
tool capable of attenuating beta-amyloid evoked neuroinflammatory responses."
— Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by
suppressing IL-1beta and iNOS expression [7] ”
“
"Our
results emphasize the potential use of CBr agonists in the regulation of
inflammatory processes within the brain; this knowledge may lead to the use of CBr
agonists in the treatment of neurodegenerative diseases associated with chronic
neuroinflammation, such as Alzheimer disease"
— Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a
rodent model of chronic brain inflammation [8] ”
Forskare i USA rapporterade 2006 om att THC hämmar enzymen som är ansvariga för uppbyggnaden
av beta-amyloid peptid i plack effektivare än vanliga alzheimersmediciner som Donepezil och Takrin.
“
"It
is noteworthy that THC is a considerably more effective inhibitor of AChE-induced
Aβ deposition than the approved drugs for Alzheimer's disease treatment, donepezil
and tacrine, which reduced Aβ aggregation by only 22% and 7%, respectively, at
twice the concentration used in our studies.7 Therefore, AChE inhibitors such as THC
and its analogues may provide an improved therapeutic for Alzheimer's disease,
augmenting acetylcholine levels by preventing neurotransmitter degradation and
reducing Aβ aggregation, thereby simultaneously treating both the symptoms and
progression of Alzheimer's disease."
— A Molecular Link Between the Active Component of Marijuana and
Alzheimer's Disease Pathology [9]
”
Det finns därtill ett antal studier som påvisar att cannabinoider kan reducera stress och leda till en
viktuppgång för patienter med sjukdomen. Forskare vid Charite Universitätmedizin i Berlin
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