toxicological profile for malathion - Agency for Toxic Substances and ...

Species
(Strain)
ACUTE EXPOSURE
Death
Exposure/
Duration/
Frequency
(Specific Route)
System
Table 3-3 Levels of Significant Exposure to Malathion - Dermal
LOAEL
Reference
NOAEL Less Serious Serious Chemical Form
Rat
(Sherman)
Systemic
once 4444 M
mg/kg/day
(4/10 males died)
Human
Immuno/ Lymphoret
5-10 min Ocular 21 M
mg/m³
85 M
mg/m³
(slight conjunctival
irritation)
Rat
(Sprague- Dawley)
once 2 F
mg/kg/day
(increased serum
histamine levels 4 hours
after dosing)
Mouse 2 d
(BALB/c)
1 x/d
148 F
mg/kg/day
Mouse once 2 F
(C57BL/ 6N)
mg/kg/day
INTERMEDIATE EXPOSURE
Death
Gn Pig 30 d
(NS)
1 x/d
Systemic
Rat 4 wk
(Long- Evans)
5
(topical)
d/wk
20 F
mg/kg/day
(increased serum
histamine levels 4 hours
after dosing)
Ocular 500 M
mg/kg/day
(mild eye irritation)
Bd Wt 500 M
mg/kg/day
200 M
(4/10 died during days
mg/kg/day
20-30)
Gaines 1960
Golz 1959
Rodgers and Xiong 1997b
Cushman and Street 1983
Rodgers and Xiong 1997b
Dikshith et al. 1987
Boyes et al. 1999