toxicological profile for malathion - Agency for Toxic Substances and ...

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56
57
58
59
60
Species
(Strain)
Exposure/
Duration/
Frequency
(Specific Route)
Death
Rat 13 wk
(Fischer- 344)
ad libitum
(F)
Mouse
(B6C3F1)
Systemic
Human
Rat
(CFY)
Rat
(Wistar)
Rat
(Wistar)
6 wk
ad libitum
(F)
32-56 d
1 x/d
(C)
System
Hemato
Renal
Table 3-2 Levels of Significant Exposure to Malathion - Oral
NOAEL
(mg/kg/day)
0.34 M
0.34 M
Less Serious
LOAEL
Serious
(mg/kg/day) (mg/kg/day)
(continued)
1399 (5/10 males died by week 9)
(9/10 females died by week 5)
6432 M (4/10 died by week 3)
Reference
Chemical Form
NCI 1979a
NCI 1978
Moeller and Rider 1962
90 d Desi et al. 1976
Hemato 75 F
(F)
6 wk
ad libitum
(F)
20 d
1x/d
(G)
Hepatic
Renal
Bd Wt
Endocr
Bd Wt
Bd Wt
75 F
75 F
75 F
29 M
29 M
20 M
Foster 1968
Krause et al. 1976