toxicological profile for malathion - Agency for Toxic Substances and ...

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Species
(Strain)
Exposure/
Duration/
Frequency
(Specific Route)
System
Table 3-2 Levels of Significant Exposure to Malathion - Oral
NOAEL
(mg/kg/day)
Less Serious
LOAEL
Serious
(mg/kg/day) (mg/kg/day)
(continued)
Reference
Chemical Form
Immuno/ Lymphoret
Mouse
(Hissar)
3 -12 wk
(F)
4.2 M 10.5 M (decreased humoral and cellmediated
responses to
antigens)
Banerjee et al. 1998
Mouse
(C57BL/6N)
28 d
1 x/2d
(GO)
Mouse 90 d
(C57BL/ 6N)
1 x/d
(GO)
Rabbit 21 wk
(New
1 x/d
Zealand) (G)
71 Rabbit 6 wk
(NS)
Neurological
5 d/wk
(C)
72 Human 32-56 d
1 x/d
(C)
73
74
Rat
(CFY)
Rat
(albino)
90 d
ad libitum
(F)
32 d
1 x/d
(GO)
0.5 M
0.23 c M
38
55 F
0.018 F (incrased primary humoal
response to SRBC)
0.1 F (increased macrophage function
and mast cell degranulation)
2.5 M (significant decrease in some
tests of humoral and
cell-mediated immunity)
5 M (decreased humoral immune
response to Salmonella
vaccine)
0.34 M (25% depression of plasma and
RBC cholinesterase)
75 F (increased excitability as shown
by changes in the EEG and
EMG)
137.5 F (37% inhibition of RBC
cholinesterase; 58% inhibition of
plasma cholinesterase)
Johnson et al. 2002
Rodgers and Xiong 1997c
Banerjee et al. 1998
Desi et al. 1978
Moeller and Rider 1962
Desi et al. 1976
Husain et al. 1987