toxicological profile for malathion - Agency for Toxic Substances and ...

Species
(Strain)
Systemic
Exposure/
Duration/
Frequency
(Specific Route)
Rabbit 3 wk
(New Zealand)
5 d/wk
6 hr/d
Neurological
Rat 4 wk
(Long- Evans)
5
(topical)
d/wk
Gn Pig 30 d
(NS)
1 x/d
Rabbit 3 wk
(New Zealand)
5 d/wk
6 hr/d
System
Table 3-3 Levels of Significant Exposure to Malathion - Dermal (continued)
Hemato 1000
mg/kg/day
Hepatic 1000
mg/kg/day
Renal 1000
mg/kg/day
Endocr 1000
mg/kg/day
Dermal 1000
mg/kg/day
Bd Wt 1000
mg/kg/day
LOAEL
Reference
NOAEL Less Serious Serious Chemical Form
500 M
mg/kg/day
50 M
mg/kg/day
200
mg/kg/day
300 F
mg/kg/day
M (45-52% inhibition of
brain and RBC
cholinesterase)
(26% inhibition of RBC
cholinesterase)
1000 M
(65% inhibition of
mg/kg/day
cerebrum cholinesterase)
Moreno 1989
Boyes et al. 1999
Dikshith et al. 1987
Moreno 1989
Bd Wt = body weight; d = day(s); Endocr = endocrine; F = female; Gn Pig = Guinea Pig; Hemato = hematological; hr = hour(s); Immuno/Lymphoret = immunological/lymphoreticular;
LOAEL = lowest-observed-effect level; M = male; mg/kg/day = milligram/kilogram/day; min = minute(s); NOAEL = no-observed-adverse-effect level; RBC = red blood cell(s); wk =
week(s); x = times