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a Key to figure 92 Species (Strain) Exposure/ Duration/ Frequency (Specific Route) Systemic Rat 103 wk (Fischer- 344) ad libitum (F) System Resp Cardio Table 3-2 Levels of Significant Exposure to Malathion - Oral NOAEL (mg/kg/day) 332 332 Less Serious LOAEL Serious (mg/kg/day) (mg/kg/day) Gastro 166 M (chronic inflammation of the stomach <strong>and</strong> stomach ulcers) Musc/skel 332 Hepatic 166 F (fatty metamorphosis of the liver) Renal Endocr Dermal 332 332 332 Bd Wt 166 332 M (>10% reduction in final body weight) (continued) Reference Chemical Form NCI 1979a
a Key to figure 93 94 Species (Strain) Systemic Mouse (B6C3F1) Mouse (B6C3F1) Exposure/ Duration/ Frequency (Specific Route) 80 wk ad libitum (F) 18 mo ad libitum (F) 95 Neurological Rat 2 yr (Fischer- 344) ad libitum (F) System Resp Cardio Gastro Musc/skel Hepatic Renal Endocr Dermal Table 3-2 Levels of Significant Exposure to Malathion - Oral NOAEL (mg/kg/day) 2980 2980 2980 2980 2980 2980 2980 Less Serious LOAEL Serious (mg/kg/day) (mg/kg/day) 2980 (coughing <strong>and</strong> sneezing from week 72 until end of study) Bd Wt 1490 (>10% lower body weight than controls) Resp 17.4 M 167 F (increased incidence of non-neoplastic nasal lesions) Hepatic 167 F 1476 M (hepatocellular hypertrophy) Bd Wt 167 F 1476 M (14-20% decreased body weight) Other 167 F 1476 M (decreased food consumption) 2 d M 29 e M (29% inhibition of plasma cholinesterase) 35 F (27% inhibition of RBC cholinesterase) (continued) 359 M (64% inhibition of plasma cholinesterase) Reference Chemical Form NCI 1978 Slauter 1994 Daly 1996a
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TOXICOLOGICAL PROFILE FOR MALATHION
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MALATHION iii UPDATE STATEMENT A To
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MALATHION viii Managing Hazardous M
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MALATHION xi PEER REVIEW A peer rev
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MALATHION xiv 3.2.3.2 Systemic Effe
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MALATHION xvii LIST OF FIGURES 3-1.
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MALATHION 1 1. PUBLIC HEALTH STATEM
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MALATHION 108 3. HEALTH EFFECTS was
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MALATHION 110 3. HEALTH EFFECTS fir
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MALATHION 112 3.4.2.3 Dermal Exposu
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MALATHION 114 3. HEALTH EFFECTS neu
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MALATHION 116 3. HEALTH EFFECTS aci
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MALATHION 118 3.4.4.1 Inhalation Ex
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MALATHION 120 3. HEALTH EFFECTS agr
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MALATHION 122 V E N O U S BLOOD 3.
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MALATHION 124 3. HEALTH EFFECTS Tab
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MALATHION 126 3. HEALTH EFFECTS mus
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MALATHION 128 3.5.2 Mechanisms of T
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MALATHION 130 3. HEALTH EFFECTS pla
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MALATHION 132 3. HEALTH EFFECTS In
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MALATHION 134 3. HEALTH EFFECTS Ove
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MALATHION 136 3. HEALTH EFFECTS are
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MALATHION 138 3. HEALTH EFFECTS whe
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MALATHION 140 3. HEALTH EFFECTS the
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MALATHION 142 3. HEALTH EFFECTS org
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MALATHION 144 3. HEALTH EFFECTS The
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MALATHION 146 3. HEALTH EFFECTS pla
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MALATHION 148 3. HEALTH EFFECTS org
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MALATHION 150 3. HEALTH EFFECTS stu
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MALATHION 152 3. HEALTH EFFECTS Par
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MALATHION 154 3. HEALTH EFFECTS exp
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MALATHION 156 3. HEALTH EFFECTS wer
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MALATHION 160 3. HEALTH EFFECTS Lee
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MALATHION 162 3. HEALTH EFFECTS res
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MALATHION 164 3. HEALTH EFFECTS inf
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MALATHION 166 3. HEALTH EFFECTS med
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MALATHION 168 4. CHEMICAL AND PHYSI
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MALATHION 171 5. PRODUCTION, IMPORT
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MALATHION 173 5. PRODUCTION, IMPORT
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MALATHION 175 6.1 OVERVIEW 6. POTEN
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MALATHION 177 6. POTENTIAL FOR HUMA
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MALATHION 187 6.3.2.1 Air 6. POTENT
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MALATHION 216 7. ANALYTICAL METHODS
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MALATHION 224 7.3.1 Identification
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MALATHION 226 8. REGULATIONS AND AD
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MALATHION 238 9. REFERENCES *Agency
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MALATHION 240 9. REFERENCES *Barnes
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MALATHION 242 9. REFERENCES *Brown
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MALATHION 244 9. REFERENCES *Choi P
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MALATHION 246 9. REFERENCES *De Ble
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MALATHION 248 9. REFERENCES Ehrich
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MALATHION 250 9. REFERENCES EPA. 20
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MALATHION 252 9. REFERENCES *Gaines
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MALATHION 254 9. REFERENCES *Harman
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MALATHION 256 9. REFERENCES Jianmon
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MALATHION 258 9. REFERENCES Kimbrou
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MALATHION 260 9. REFERENCES *Lechne
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MALATHION 262 9. REFERENCES *Mackis
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MALATHION 264 9. REFERENCES Mohn G.
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MALATHION 266 9. REFERENCES NIOSH.
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MALATHION 268 9. REFERENCES *Prabha
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MALATHION 270 9. REFERENCES *Roy RR
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MALATHION 272 9. REFERENCES *Singar
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MALATHION 274 9. REFERENCES *Thongs
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MALATHION 276 9. REFERENCES Viccell
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MALATHION 278 9. REFERENCES Yess NJ
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MALATHION 280 10. GLOSSARY Ceiling
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MALATHION 282 10. GLOSSARY Mutagen
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MALATHION 284 10. GLOSSARY Risk—T
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MALATHION A-2 APPENDIX A are not ex
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MALATHION A-4 APPENDIX A Was a conv
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MALATHION A-6 APPENDIX A Was a conv
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MALATHION A-8 APPENDIX A If an inha
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MALATHION A-10 Uncertainty Factors
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MALATHION B-2 Interpretation of Min
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MALATHION B-4 APPENDIX B (8) NOAEL
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1 2 3 4 12 → → → → → Key
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MALATHION C-1 APPENDIX C. ACRONYMS,
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MALATHION C-3 APPENDIX C MFO mixed
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MALATHION C-5 > greater than $ grea
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