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MALATHION B-5 APPENDIX B (17) CEL Key number 38r is 1 of 3 studies for which Cancer Effect Levels were derived. The diamond symbol refers to a Cancer Effect Level for the test species-mouse. The number 38 corresponds to the entry in the LSE table. (18) Estimated Upper-Bound Human Cancer Risk Levels This is the range associated with the upperbound for lifetime cancer risk of 1 in 10,000 to 1 in 10,000,000. These risk levels are derived from the EPA's Human Health Assessment Group's upper-bound estimates of the slope of the cancer dose response curve at low dose levels (q1*). (19) Key to LSE Figure The Key explains the abbreviations and symbols used in the figure.
1 2 3 4 12 → → → → → Key to figure a Species INTERMEDIATE EXPOSURE Systemic 18 ↓ Rat 5 CHRONIC EXPOSURE Cancer 38 39 40 Rat Rat Mouse Exposure frequency/ duration ↓ 6 13 wk 5 d/wk 6 hr/d 18 mo 5 d/wk 7 hr/d 89-104 wk 5 d/wk 6 hr/d 79-103 wk 5 d/wk 6 hr/d System ↓ 7 Resp NOAEL (ppm) 8 ↓ 3 b SAMPLE TABLE 3-1. Levels of Significant Exposure to [Chemical x] - Inhalation Less serious (ppm) ↓ 9 10 (hyperplasia) LOAEL (effect) 11 ↓ 20 10 10 Serious (ppm) (CEL, multiple organs) (CEL, lung tumors, nasal tumors) (CEL, lung tumors, hemangiosarcomas) Reference 10 ↓ Nitschke et al. 1981 Wong et al. 1982 NTP 1982 NTP 1982 a The number corresponds to entries in Figure 3-1. b Used to derive an intermediate inhalation Minimal Risk Level (MRL) of 5 x 10 -3 ppm; dose adjusted for intermittent exposure and divided by an uncertainty factor of 100 (10 for extrapolation from animal to humans, 10 for human variability). APPENDIX B MALATHION B-6
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TOXICOLOGICAL PROFILE FOR MALATHION
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MALATHION iii UPDATE STATEMENT A To
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MALATHION viii Managing Hazardous M
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MALATHION xi PEER REVIEW A peer rev
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MALATHION xiv 3.2.3.2 Systemic Effe
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MALATHION xvii LIST OF FIGURES 3-1.
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MALATHION 1 1. PUBLIC HEALTH STATEM
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MALATHION 11 1. PUBLIC HEALTH STATE
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MALATHION 14 2. RELEVANCE TO PUBLIC
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MALATHION 24 3. HEALTH EFFECTS oral
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MALATHION 26 3. HEALTH EFFECTS sing
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≤
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MALATHION 30 3. HEALTH EFFECTS Resp
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MALATHION 32 3. HEALTH EFFECTS Rena
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MALATHION 34 3. HEALTH EFFECTS Stud
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MALATHION 36 3. HEALTH EFFECTS Fran
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MALATHION 38 3. HEALTH EFFECTS more
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MALATHION 40 3. HEALTH EFFECTS the
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a Key to figure 1 2 3 4 5 6 Species
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a Key to figure 15 16 17 18 Species
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a Key to figure 24 25 26 27 28 29 S
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a Key to figure 40 41 42 43 44 45 S
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a Key to figure 55 56 57 58 59 60 S
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a Key to figure 67 68 69 70 Species
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a Key to figure 83 84 85 86 87 88 8
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a Key to figure 91 Species (Strain)
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a Key to figure 93 94 Species (Stra
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≤
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≤
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MALATHION 64 3.2.2.2 Systemic Effec
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MALATHION 66 3. HEALTH EFFECTS 1965
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MALATHION 68 3. HEALTH EFFECTS Hepa
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MALATHION 70 3. HEALTH EFFECTS appr
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MALATHION 72 3. HEALTH EFFECTS an u
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MALATHION 74 3. HEALTH EFFECTS Meta
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MALATHION 76 3. HEALTH EFFECTS clas
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MALATHION 78 3. HEALTH EFFECTS was
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MALATHION 80 3. HEALTH EFFECTS appr
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MALATHION 82 3. HEALTH EFFECTS Clin
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MALATHION 84 3. HEALTH EFFECTS mala
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MALATHION 86 3. HEALTH EFFECTS Tera
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MALATHION 88 3. HEALTH EFFECTS for
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MALATHION 90 3. HEALTH EFFECTS sugg
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Species (Strain) Systemic Exposure/
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MALATHION 94 3. HEALTH EFFECTS Endo
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MALATHION 96 3. HEALTH EFFECTS Othe
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MALATHION 98 3. HEALTH EFFECTS derm
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MALATHION 100 3. HEALTH EFFECTS al.
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MALATHION 102 3. HEALTH EFFECTS of
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MALATHION 104 3. HEALTH EFFECTS per
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MALATHION 106 3.4.1.1 Inhalation Ex
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MALATHION 108 3. HEALTH EFFECTS was
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MALATHION 110 3. HEALTH EFFECTS fir
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MALATHION 112 3.4.2.3 Dermal Exposu
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MALATHION 114 3. HEALTH EFFECTS neu
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MALATHION 116 3. HEALTH EFFECTS aci
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MALATHION 118 3.4.4.1 Inhalation Ex
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MALATHION 120 3. HEALTH EFFECTS agr
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MALATHION 122 V E N O U S BLOOD 3.
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MALATHION 124 3. HEALTH EFFECTS Tab
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MALATHION 126 3. HEALTH EFFECTS mus
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MALATHION 128 3.5.2 Mechanisms of T
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MALATHION 130 3. HEALTH EFFECTS pla
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MALATHION 132 3. HEALTH EFFECTS In
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MALATHION 134 3. HEALTH EFFECTS Ove
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MALATHION 136 3. HEALTH EFFECTS are
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MALATHION 138 3. HEALTH EFFECTS whe
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MALATHION 140 3. HEALTH EFFECTS the
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MALATHION 142 3. HEALTH EFFECTS org
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MALATHION 144 3. HEALTH EFFECTS The
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MALATHION 146 3. HEALTH EFFECTS pla
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MALATHION 148 3. HEALTH EFFECTS org
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MALATHION 150 3. HEALTH EFFECTS stu
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MALATHION 152 3. HEALTH EFFECTS Par
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MALATHION 154 3. HEALTH EFFECTS exp
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MALATHION 156 3. HEALTH EFFECTS wer
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MALATHION 158 3. HEALTH EFFECTS who
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MALATHION 160 3. HEALTH EFFECTS Lee
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MALATHION 162 3. HEALTH EFFECTS res
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MALATHION 164 3. HEALTH EFFECTS inf
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MALATHION 166 3. HEALTH EFFECTS med
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MALATHION 168 4. CHEMICAL AND PHYSI
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MALATHION 171 5. PRODUCTION, IMPORT
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MALATHION 173 5. PRODUCTION, IMPORT
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MALATHION 175 6.1 OVERVIEW 6. POTEN
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MALATHION 177 6. POTENTIAL FOR HUMA
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MALATHION 187 6.3.2.1 Air 6. POTENT
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MALATHION 216 7. ANALYTICAL METHODS
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MALATHION 224 7.3.1 Identification
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MALATHION 226 8. REGULATIONS AND AD
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MALATHION 238 9. REFERENCES *Agency
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MALATHION 240 9. REFERENCES *Barnes
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MALATHION 242 9. REFERENCES *Brown
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MALATHION 244 9. REFERENCES *Choi P
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MALATHION 246 9. REFERENCES *De Ble
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Page 271 and 272: MALATHION 252 9. REFERENCES *Gaines
Page 273 and 274: MALATHION 254 9. REFERENCES *Harman
Page 275 and 276: MALATHION 256 9. REFERENCES Jianmon
Page 277 and 278: MALATHION 258 9. REFERENCES Kimbrou
Page 279 and 280: MALATHION 260 9. REFERENCES *Lechne
Page 281 and 282: MALATHION 262 9. REFERENCES *Mackis
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Page 285 and 286: MALATHION 266 9. REFERENCES NIOSH.
Page 287 and 288: MALATHION 268 9. REFERENCES *Prabha
Page 289 and 290: MALATHION 270 9. REFERENCES *Roy RR
Page 291 and 292: MALATHION 272 9. REFERENCES *Singar
Page 293 and 294: MALATHION 274 9. REFERENCES *Thongs
Page 295 and 296: MALATHION 276 9. REFERENCES Viccell
Page 297 and 298: MALATHION 278 9. REFERENCES Yess NJ
Page 299 and 300: MALATHION 280 10. GLOSSARY Ceiling
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Page 324 and 325: MALATHION C-3 APPENDIX C MFO mixed
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