toxicological profile for malathion - Agency for Toxic Substances and ...

a
Key to
figure
40
41
42
43
44
45
Species
(Strain)
Reproductive
Rat 14 d
(Wistar)
1x/2d
(G)
Rat
(Wistar)
Exposure/
Duration/
Frequency
(Specific Route)
2 d
1x/d
(G)
Rat 10 d
(Sprague-
Gd 6-15
Dawley) (GO)
Rat
(Wistar)
7 d
1x/d
(F)
System
Table 3-2 Levels of Significant Exposure to Malathion - Oral
NOAEL
(mg/kg/day)
800
18.5
Less Serious
LOAEL
Serious
(mg/kg/day) (mg/kg/day)
10 M (significant increase in serum
FSH levels)
40 M (reversible damage to
spermatogenetic tissue)
163 (minor histopathological lesions
in testes, ovaries, and uterus)
(continued)
Reference
Chemical Form
Krause 1977
Krause et al. 1976
Lochry 1989
Ojha et al. 1992
Rat
(Wistar)
once
(G)
1950 M (reversible degeneration and
necrosis of gonocytes in
seminiferous tubules)
Piramanayagam et al. 1996
Rat 3 d
(Sprague-
Gd 6, 10, 14
Dawley) (GO)
46 Rabbit 13 d
(New
Gd 6-18
Zealand) (GO)
Developmental
47 Rat
10 d
(Wistar)
Gd 6-15
1x/d
(GO)
25
300
500 F (decreased number of implants
per dam)
50 (increased mean number and
percent resorptions)
Prabhakaran et al. 1993
Siglin 1985
Khera et al. 1978