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a Key to figure 48 49 50 51 52 53 Species (Strain) Developmental Rat 10 d (Sprague- Gd 6-15 Dawley) 1x/d (GO) Rat (Sprague- Dawley) Exposure/ Duration/ Frequency (Specific Route) 8 d Gd 6-13 1 x/d (GO) Rat 3 d (Sprague- Gd 6, 10, 14 Dawley) (GO) Rabbit (New Zealand) Rabbit (New Zealand) Rabbit (New Zealand) 6 d Gd 7-12 1 x/d (GO) 3 d Gd 28-30 1 x/d (GO) 13 d Gd 6-18 1x/d (GO) INTERMEDIATE EXPOSURE 54 Death Rat 6 wk (Osbornead libitum Mendel) (F) System Table 3-2 Levels of Significant Exposure to Malathion - Oral NOAEL (mg/kg/day) 800 276 100 100 Less Serious LOAEL Serious (mg/kg/day) (mg/kg/day) 827 (47% inhibition of brain AChE in pups) (continued) Reference Chemical Form Lochry 1989 Mathews and Devi 1994 Prabhakaran et al. 1993 500 (reduced number of live fetuses per litter and fetal weight) 126 (79% decrease fetal plasma AChE activity; 66% decrease fetal brain AChE activity) Machin and McBride 1989a Machin and McBride 1989b Siglin 1985 NCI 1978 2816 (5/5 males and 5/5 females died by week 3)
a Key to figure 55 56 57 58 59 60 Species (Strain) Exposure/ Duration/ Frequency (Specific Route) Death Rat 13 wk (Fischer- 344) ad libitum (F) Mouse (B6C3F1) Systemic Human Rat (CFY) Rat (Wistar) Rat (Wistar) 6 wk ad libitum (F) 32-56 d 1 x/d (C) System Hemato Renal Table 3-2 Levels of Significant Exposure to Malathion - Oral NOAEL (mg/kg/day) 0.34 M 0.34 M Less Serious LOAEL Serious (mg/kg/day) (mg/kg/day) (continued) 1399 (5/10 males died by week 9) (9/10 females died by week 5) 6432 M (4/10 died by week 3) Reference Chemical Form NCI 1979a NCI 1978 Moeller and Rider 1962 90 d Desi et al. 1976 Hemato 75 F (F) 6 wk ad libitum (F) 20 d 1x/d (G) Hepatic Renal Bd Wt Endocr Bd Wt Bd Wt 75 F 75 F 75 F 29 M 29 M 20 M Foster 1968 Krause et al. 1976
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TOXICOLOGICAL PROFILE FOR MALATHION
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MALATHION iii UPDATE STATEMENT A To
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MALATHION viii Managing Hazardous M
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MALATHION xi PEER REVIEW A peer rev
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MALATHION xiv 3.2.3.2 Systemic Effe
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MALATHION 102 3. HEALTH EFFECTS of
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MALATHION 104 3. HEALTH EFFECTS per
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MALATHION 106 3.4.1.1 Inhalation Ex
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MALATHION 108 3. HEALTH EFFECTS was
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MALATHION 110 3. HEALTH EFFECTS fir
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MALATHION 112 3.4.2.3 Dermal Exposu
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MALATHION 114 3. HEALTH EFFECTS neu
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MALATHION 116 3. HEALTH EFFECTS aci
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MALATHION 118 3.4.4.1 Inhalation Ex
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MALATHION 120 3. HEALTH EFFECTS agr
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MALATHION 122 V E N O U S BLOOD 3.
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MALATHION 124 3. HEALTH EFFECTS Tab
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MALATHION 126 3. HEALTH EFFECTS mus
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MALATHION 128 3.5.2 Mechanisms of T
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MALATHION 130 3. HEALTH EFFECTS pla
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MALATHION 132 3. HEALTH EFFECTS In
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MALATHION 136 3. HEALTH EFFECTS are
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MALATHION 138 3. HEALTH EFFECTS whe
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MALATHION 142 3. HEALTH EFFECTS org
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MALATHION 146 3. HEALTH EFFECTS pla
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MALATHION 152 3. HEALTH EFFECTS Par
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MALATHION 164 3. HEALTH EFFECTS inf
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MALATHION 166 3. HEALTH EFFECTS med
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MALATHION 168 4. CHEMICAL AND PHYSI
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MALATHION 171 5. PRODUCTION, IMPORT
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MALATHION 173 5. PRODUCTION, IMPORT
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MALATHION 175 6.1 OVERVIEW 6. POTEN
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MALATHION 177 6. POTENTIAL FOR HUMA
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MALATHION 187 6.3.2.1 Air 6. POTENT
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MALATHION 216 7. ANALYTICAL METHODS
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MALATHION 224 7.3.1 Identification
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MALATHION 226 8. REGULATIONS AND AD
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MALATHION 238 9. REFERENCES *Agency
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MALATHION 240 9. REFERENCES *Barnes
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MALATHION 242 9. REFERENCES *Brown
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MALATHION 244 9. REFERENCES *Choi P
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MALATHION 246 9. REFERENCES *De Ble
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MALATHION 248 9. REFERENCES Ehrich
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MALATHION 250 9. REFERENCES EPA. 20
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MALATHION 252 9. REFERENCES *Gaines
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MALATHION 254 9. REFERENCES *Harman
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MALATHION 256 9. REFERENCES Jianmon
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MALATHION 262 9. REFERENCES *Mackis
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MALATHION 264 9. REFERENCES Mohn G.
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MALATHION 266 9. REFERENCES NIOSH.
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MALATHION 268 9. REFERENCES *Prabha
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MALATHION 272 9. REFERENCES *Singar
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MALATHION 274 9. REFERENCES *Thongs
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MALATHION 276 9. REFERENCES Viccell
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MALATHION 278 9. REFERENCES Yess NJ
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MALATHION 280 10. GLOSSARY Ceiling
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MALATHION 282 10. GLOSSARY Mutagen
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MALATHION 284 10. GLOSSARY Risk—T
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MALATHION A-2 APPENDIX A are not ex
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MALATHION A-4 APPENDIX A Was a conv
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MALATHION A-6 APPENDIX A Was a conv
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MALATHION A-8 APPENDIX A If an inha
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MALATHION A-10 Uncertainty Factors
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MALATHION B-2 Interpretation of Min
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MALATHION B-4 APPENDIX B (8) NOAEL
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1 2 3 4 12 → → → → → Key
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MALATHION C-1 APPENDIX C. ACRONYMS,
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MALATHION C-3 APPENDIX C MFO mixed
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MALATHION C-5 > greater than $ grea
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