toxicological profile for malathion - Agency for Toxic Substances and ...

a
Key to
figure
19
20
21
22
Species
(Strain)
Systemic
Rat
(Wistar)
Rat
(Wistar)
Rat
(Wistar)
Mouse
(C57BL/ 6N)
Exposure/
Duration/
Frequency
(Specific Route)
System
Table 3-2 Levels of Significant Exposure to Malathion - Oral
NOAEL
(mg/kg/day)
Less Serious
LOAEL
Serious
(mg/kg/day) (mg/kg/day)
(continued)
Reference
Chemical Form
once Piramanayagam et al. 1996
Resp
1950 M (hemorrhage and hyperemia in
(G)
the lungs)
6 d
1x/d
(GW)
6 d
1x/d
(GW)
Cardio 1950 M (congestion and hemorrhage in
the heart)
Hepatic 1950 M (liver congestion and
hemorrhage; hepatocytes
vacuolation and necrosis)
Renal 1950 M (kidney
congestion;degenerative
changes in tubular epithelium)
Endocr
Bd Wt
Gastro
Endocr
Bd Wt
225 M
225 M
225 M
225 M (increased pituitary gland weight
and serum prolactin levels;
decrease pituitary prolactin)
22 M (diarrhea after the first dose)
Simionescu et al. 1977
Simionescu et al. 1977
once Rodgers et al. 1986
Bd Wt 715 F
(GO)
Immuno/ Lymphoret
23 Rat
(Sprague-
Dawley)
once
(GO)
1F 10 F (increased serum histamine
levels 4 hours after dosing)
Rodgers and Xiong 1997b