toxicological profile for malathion - Agency for Toxic Substances and ...

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Species
(Strain)
Immuno/ Lymphoret
Exposure/
Duration/
Frequency
(Specific Route)
System
Table 3-2 Levels of Significant Exposure to Malathion - Oral
NOAEL
(mg/kg/day)
Less Serious
LOAEL
Serious
(mg/kg/day) (mg/kg/day)
(continued)
Reference
Chemical Form
Mouse once Casale et al. 1983
720 M (suppression of primary IgM
(C57BL/ 6N) (GO)
response)
Mouse 4 d Casale et al. 1983
240 M
(C57BL/ 6N) (GO)
Mouse
(C57BL/ 6N)
once
(GO)
715 F (increased proliferative
response of splenocytes
following exposure to polyclonal
activators)
Rodgers and Ellefson 1990
Mouse once Rodgers and Xiong 1996
450 F (stimulation of macrophage
(C57BL/ 6N) (GO)
function)
Mouse once Rodgers and Xiong 1997b
1F 10 F (increased serum histamine
(C57BL/ 6N) (GO)
levels 4 hours after dosing)
Mouse 14 d
(C57BL/ 6N)
1 x/d
(GO)
0.1 F (degranulation of mast cells
associated with the small
intestine)
Rodgers and Xiong 1997d
30 Mouse
(C57BL/ 6N)
Neurological
14 d
1 x/d
(GO)
143 F (decrease in thymic lymphocyte
number)
Rodgers et al. 1986
31 Rat
once
(Long- Evans) (GO)
600 M (increased spontaneous motor
activity)
Ehrich et al. 1993