toxicological profile for malathion - Agency for Toxic Substances and ...

MALATHION 113
O,O-DMPDT
(dimethyl phosphorodithioic acid)
CH3O S
P
CH3O SH
CH3O S
P
CH3O S
malathion
3. HEALTH EFFECTS
Figure 3-3. Metabolic Pathways for Malathion
O
O
O
O
CH3O S
P
O
CH3O S
P
O
CH3O O
P
CH3O S
O
CH3O S
O
CH3O S
O
O
O
CH3O S
P
CH3O S
?
O
O
?
O
O
O,O-DMPT
(dimethyl phosphorothioic acid)
O
CH3O S
P
CH3O O
CH3O O
P
CH3O S
malaoxon
O
O
O
O
O,O-DMP
(dimethyl phosphoric acid)
CH3O O
P
CH3O S
O
O
O
O
CH3O O
P
CH3O S
O
O
CH3O O
P
CH3O O
malathion MCA (monocarboxylic acid) malaoxon MCA (monocarboxylic acid)
alpha-MCA beta-MCA alpha-MCA
beta-MCA
malathion DCA (dicarboxylic acid) malaoxon DCA (dicarboxylic acid)
O S
P
CH3O S
mixed function oxidase
hydrolase
demethyl malathion demethyl malaoxon
O
O
mixed function oxidase
O
O
O O
P
CH3O S
O
O
O
O
A-esterase
hydrolase
carboxylesterase carboxylesterase
carboxylesterase
GSH S-transferase
?
?
O
O
O
O
O
O
carboxylesterase