toxicological profile for malathion - Agency for Toxic Substances and ...

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Key to
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62
63
64
65
Species
(Strain)
Systemic
Rat
(Sprague-
Dawley)
Exposure/
Duration/
Frequency
(Specific Route)
6 mo
ad libitum
(W)
Rat 13 wk
(Fischer- 344)
ad libitum
(F)
Rat
(albino)
Mouse
(Hissar)
Dog
(Beagle)
15 wk
1x/d
(GO)
Immuno/ Lymphoret
66 Rat
8 -22 wk
(Wistar)
ad libitum
(F)
System
Hemato
Table 3-2 Levels of Significant Exposure to Malathion - Oral
NOAEL
(mg/kg/day)
Less Serious
LOAEL
Serious
(mg/kg/day) (mg/kg/day)
0.15 F (prolonged prothrombin and
partial thromboplastin times)
Hepatic 0.15 F (hepatocyte degeneration)
Bd Wt
Bd Wt
Endocr
0.15 F
700
10 (significant decrease in serum
cortizol and aldosterone levels,
and congestion in zona
reticularis of adrenal glands in
both sexes)
(continued)
1399 F (final body weight reduced 50%
relative to controls)
Reference
Chemical Form
Lox and Davis 1983
NCI 1979a
Ozmen and Akay 1993
3 -12 wk Banerjee et al. 1998
Hepatic 10.5 M 21 M (increased relative liver weight)
(F)
Bd Wt
21 M
28 d Fischer 1988
Gastro
125 (diarrhea)
(C)
2.3 M
5.8 M (reduced humoral and
cell-mediated immune
responses to antigens)
Banerjee et al. 1998