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MALATHION 229 8. REGULATIONS AND ADVISORIES Table 8-1. Regulations and Guidelines Applicable to Malathion Agency Description Information References residues (ppm) Passion fruit Peaches Peanut (forage and hay) Peanuts Pears Peas Peavine (including hay) Pecans Peppermint Peppers Pineapple Plums Potatoes Poultry (fat, meat byproducts, meat) Prunes Pumpkins Quinces Radishes Raspberries Rice (grain and wild) Rutabagas Rye (grain) Safflower (seed) Salsify (including tops) Shallots Sheep (fat, meat byproducts, meat) Sorghum (forage and grain) Soybeans (dry and succulent) Soybeans (forage and hay) Spearmint Squash (summer and winter) Strawberries Sunflower seeds Sweet potatoes Tangerines Tomatoes Turnips (including tops) Vegetables (leafy, including Brassica) Vetch (hay and straw) Vetch (seed) Walnuts Wheat (grain) USDA Agriculture—labeling of treated seed shall not be deemed harmful when present at a rate less than indicated 8 8 135 8 8 8 8 8 8 8 8 8 8 4 8 8 8 8 8 8 8 8 0.2 8 8 4 8 8 135 8 8 8 8 1 8 8 8 8 EPA 2001f 40CFR180.111 135 8 8 8 8 ppm USDA 2001 7CFR201.31a
MALATHION 230 8. REGULATIONS AND ADVISORIES Table 8-1. Regulations and Guidelines Applicable to Malathion Agency Description Information References NATIONAL (cont.) d. Other ACGIH BEI—organophosphorus cholinesterase inhibitors (cholinesterase activity in red cells) 70% of individual’s baseline ACGIH 1999 ACGIH Carcinogenicity classification A4 c ACGIH 2000 DOT Superfund—reportable quantity 100 pounds DOT 2001b 49CFR172.101 Appendix A EPA RfD 2x10 -2 mg/kg/day IRIS 2001 NPDES—permit application testing requirements; toxic pollutants and hazardous substances required to be identified by existing dischargers if expected to be present Standards for hazardous waste TSD facilities—compounds with Henry’s law constant less than 0.1 atm m 3 /mol (at 25 °C) EPA 2001g 40CFR122 Appendix D Table V EPA 2001h 40CFR265 Appendix VI Superfund—reportable quantity 10 pounds EPA 2001i 40CFR302.4 Toxic chemical release reporting; Community Right-to- Know—effective date STATE Regulations and Guidelines: a. Air Alaska Air contaminant standard Total dust Respirable fraction 01/01/95 EPA 2001j 40CFR372.65 BNA 2001 10 mg/m 3 5 mg/m 3 California Airborne contaminant BNA 2001 Colorado Standards applicable to surface water Human health based (water supply) Aquatic life based (chronic) Connecticut HAP—hazard limiting value 8 Hours 30 Minutes Hawaii Air contaminant (PEL-TWA) Total dust 140 µg/L 0.1 µg/L 200 µg/m 3 1,000 µg/m 3 10 mg/m 3 BNA 2001 BNA 2001 BNA 2001
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TOXICOLOGICAL PROFILE FOR MALATHION
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MALATHION iii UPDATE STATEMENT A To
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MALATHION viii Managing Hazardous M
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MALATHION xi PEER REVIEW A peer rev
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MALATHION xiv 3.2.3.2 Systemic Effe
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MALATHION xvii LIST OF FIGURES 3-1.
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MALATHION 1 1. PUBLIC HEALTH STATEM
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MALATHION 11 1. PUBLIC HEALTH STATE
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MALATHION 14 2. RELEVANCE TO PUBLIC
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MALATHION 24 3. HEALTH EFFECTS oral
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MALATHION 26 3. HEALTH EFFECTS sing
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≤
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MALATHION 30 3. HEALTH EFFECTS Resp
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MALATHION 32 3. HEALTH EFFECTS Rena
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MALATHION 34 3. HEALTH EFFECTS Stud
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MALATHION 36 3. HEALTH EFFECTS Fran
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MALATHION 38 3. HEALTH EFFECTS more
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MALATHION 40 3. HEALTH EFFECTS the
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a Key to figure 1 2 3 4 5 6 Species
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a Key to figure 15 16 17 18 Species
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a Key to figure 24 25 26 27 28 29 S
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a Key to figure 40 41 42 43 44 45 S
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a Key to figure 55 56 57 58 59 60 S
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a Key to figure 67 68 69 70 Species
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a Key to figure 83 84 85 86 87 88 8
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a Key to figure 91 Species (Strain)
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a Key to figure 93 94 Species (Stra
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≤
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≤
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MALATHION 64 3.2.2.2 Systemic Effec
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MALATHION 66 3. HEALTH EFFECTS 1965
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MALATHION 68 3. HEALTH EFFECTS Hepa
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MALATHION 70 3. HEALTH EFFECTS appr
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MALATHION 72 3. HEALTH EFFECTS an u
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MALATHION 74 3. HEALTH EFFECTS Meta
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MALATHION 76 3. HEALTH EFFECTS clas
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MALATHION 78 3. HEALTH EFFECTS was
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MALATHION 80 3. HEALTH EFFECTS appr
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MALATHION 82 3. HEALTH EFFECTS Clin
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MALATHION 84 3. HEALTH EFFECTS mala
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MALATHION 86 3. HEALTH EFFECTS Tera
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MALATHION 88 3. HEALTH EFFECTS for
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MALATHION 90 3. HEALTH EFFECTS sugg
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Species (Strain) Systemic Exposure/
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MALATHION 94 3. HEALTH EFFECTS Endo
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MALATHION 96 3. HEALTH EFFECTS Othe
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MALATHION 98 3. HEALTH EFFECTS derm
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MALATHION 100 3. HEALTH EFFECTS al.
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MALATHION 102 3. HEALTH EFFECTS of
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MALATHION 104 3. HEALTH EFFECTS per
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MALATHION 106 3.4.1.1 Inhalation Ex
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MALATHION 108 3. HEALTH EFFECTS was
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MALATHION 110 3. HEALTH EFFECTS fir
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MALATHION 112 3.4.2.3 Dermal Exposu
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MALATHION 114 3. HEALTH EFFECTS neu
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MALATHION 116 3. HEALTH EFFECTS aci
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MALATHION 118 3.4.4.1 Inhalation Ex
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MALATHION 120 3. HEALTH EFFECTS agr
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MALATHION 122 V E N O U S BLOOD 3.
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MALATHION 124 3. HEALTH EFFECTS Tab
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MALATHION 126 3. HEALTH EFFECTS mus
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MALATHION 128 3.5.2 Mechanisms of T
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MALATHION 130 3. HEALTH EFFECTS pla
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MALATHION 132 3. HEALTH EFFECTS In
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MALATHION 134 3. HEALTH EFFECTS Ove
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MALATHION 136 3. HEALTH EFFECTS are
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MALATHION 138 3. HEALTH EFFECTS whe
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MALATHION 140 3. HEALTH EFFECTS the
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MALATHION 142 3. HEALTH EFFECTS org
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MALATHION 144 3. HEALTH EFFECTS The
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MALATHION 146 3. HEALTH EFFECTS pla
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MALATHION 148 3. HEALTH EFFECTS org
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MALATHION 150 3. HEALTH EFFECTS stu
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MALATHION 152 3. HEALTH EFFECTS Par
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MALATHION 154 3. HEALTH EFFECTS exp
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MALATHION 156 3. HEALTH EFFECTS wer
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MALATHION 158 3. HEALTH EFFECTS who
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MALATHION 160 3. HEALTH EFFECTS Lee
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MALATHION 162 3. HEALTH EFFECTS res
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MALATHION 164 3. HEALTH EFFECTS inf
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MALATHION 166 3. HEALTH EFFECTS med
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MALATHION 168 4. CHEMICAL AND PHYSI
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MALATHION 171 5. PRODUCTION, IMPORT
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MALATHION 173 5. PRODUCTION, IMPORT
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MALATHION 175 6.1 OVERVIEW 6. POTEN
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MALATHION 177 6. POTENTIAL FOR HUMA
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Page 245 and 246: MALATHION 226 8. REGULATIONS AND AD
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Page 257 and 258: MALATHION 238 9. REFERENCES *Agency
Page 259 and 260: MALATHION 240 9. REFERENCES *Barnes
Page 261 and 262: MALATHION 242 9. REFERENCES *Brown
Page 263 and 264: MALATHION 244 9. REFERENCES *Choi P
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Page 267 and 268: MALATHION 248 9. REFERENCES Ehrich
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Page 271 and 272: MALATHION 252 9. REFERENCES *Gaines
Page 273 and 274: MALATHION 254 9. REFERENCES *Harman
Page 275 and 276: MALATHION 256 9. REFERENCES Jianmon
Page 277 and 278: MALATHION 258 9. REFERENCES Kimbrou
Page 279 and 280: MALATHION 260 9. REFERENCES *Lechne
Page 281 and 282: MALATHION 262 9. REFERENCES *Mackis
Page 283 and 284: MALATHION 264 9. REFERENCES Mohn G.
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Page 287 and 288: MALATHION 268 9. REFERENCES *Prabha
Page 289 and 290: MALATHION 270 9. REFERENCES *Roy RR
Page 291 and 292: MALATHION 272 9. REFERENCES *Singar
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Page 295 and 296: MALATHION 276 9. REFERENCES Viccell
Page 297 and 298: MALATHION 278 9. REFERENCES Yess NJ
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MALATHION 280 10. GLOSSARY Ceiling
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MALATHION 282 10. GLOSSARY Mutagen
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MALATHION 284 10. GLOSSARY Risk—T
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MALATHION A-2 APPENDIX A are not ex
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MALATHION A-4 APPENDIX A Was a conv
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MALATHION A-6 APPENDIX A Was a conv
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MALATHION A-8 APPENDIX A If an inha
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MALATHION A-10 Uncertainty Factors
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MALATHION B-2 Interpretation of Min
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MALATHION B-4 APPENDIX B (8) NOAEL
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1 2 3 4 12 → → → → → Key
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MALATHION C-1 APPENDIX C. ACRONYMS,
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MALATHION C-3 APPENDIX C MFO mixed
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MALATHION C-5 > greater than $ grea
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