toxicological profile for malathion - Agency for Toxic Substances and ...

MALATHION 101
3. HEALTH EFFECTS
Table 3-4. Genotoxicity of Malathion In Vivo
Species (test system)
Mammalian cells:
End point Results Reference
Mouse bone marrow Chromosomal abnormalities + Kumar et al. 1995
Mouse bone marrow Chromosomal aberrations – Degraeve and
Moutschen 1984
Mouse spermatogonia Chromosomal aberrations – Degraeve and
Moutschen 1984
Mouse spermatogonia Dominant lethal mutation – Degraeve and
Moutschen 1984
Mouse spermatogonia Chromosomal aberrations + Salvadori et al. 1988
Mouse bone marrow Micronuclei + Dulout et al. 1982
Mouse bone marrow Chromosomal aberrations + Dulout et al. 1983
Hamster bone marrow Chromosomal aberrations ± Dzwonkowska and
Hubner 1986
Mouse bone marrow Chromosomal aberrations + Abraham et al. 1997
Mouse bone marrow Micronuclei + Abraham et al. 1997
Mouse spermatocytes Meiotic index + Hoda et al. 1993
Mouse bone marrow Chromosomal aberrations + Amer et al. 2002
Mouse spermatocytes Chromosomal aberrations + Amer et al. 2002
Mouse spleen cells Chromosomal aberrations + Amer et al. 2002
Mouse spleen cells Sister chromatid exchange + Amer et al. 2002
Mouse bone marrow Chromosomal aberrations + Giri et al. 2002
Human lymphocytes Micronuclei – Titenko-Holland et al.
1997
Human lymphocytes Chromosomal aberrations + Singaravelu et al. 1998
Human lymphocytes Chromosomal aberrations + van Bao et al. 1974
Human lymphocytes Micronuclei – Windham et al. 1998
Human erythrocytes
Eukaryotic organisms:
Mutation frequencies – Windham et al. 1998
Drosophila (food) Dominant lethal + Kumar et al. 1995
Drosophila (food) Sex linked recessive lethal + Kumar et al. 1995
Drosophila (food) Wing spot test – Osaba et al. 1999
Drosophila (food) Sex linked recessive lethal – Velázquez et al. 1987
Drosophila (food) Sex chromosome losses – Velázquez et al. 1987
– = negative result; + = positive result; ± = weak positive result