toxicological profile for malathion - Agency for Toxic Substances and ...

a
Key to
figure
75
76
77
Species
(Strain)
Exposure/
Duration/
Frequency
(Specific Route)
Neurological
Rat 90 d
(Spraguead
libitum
Dawley) (F)
Rat
(Wistar)
14 d
1 x/d
(GO)
System
Table 3-2 Levels of Significant Exposure to Malathion - Oral
NOAEL
(mg/kg/day)
4
Less Serious
LOAEL
Serious
(mg/kg/day) (mg/kg/day)
(continued)
352 M (61% inhibition of RBC
cholinesterase activity)
Reference
Chemical Form
Lamb 1994b
Piramanayagam and Manohar 2002
130 M (neuronal degeneration; gliosis)
Dog 28 d Fischer 1988
125 (>20% decrease in plasma
(Beagle) (C)
cholinesterase activity)
78 Rabbit 6 wk
(NS)
Reproductive
5 d/wk
(C)
79 Rat 12 wk
(albino)
1 x/d
(GO)
80
81
82
Rat
(albino)
Rat
(Wistar)
12 wk
1 x/d
(GO)
20 d
1x/d
(G)
Rat
110 d
(Sprague-
1 x/d
Dawley) (GO)
10 M
50 F
25 M (25-30% inhibition of RBC
cholinesterase following two
weeks of treatment)
45 M (edema, congestion, and
desquamation of lining cells of
seminiferous tubules)
44 M (decrease seminal vesicle pH,
protein content, relative testes
weight and enzyme activities)
20 M (reversible damage to
spermatogenic tissue)
Desi et al. 1978
Balasubramanian et al. 1987a
Balasubramanian et al. 1987b
Krause et al. 1976
Lechner and Abdel-Rahman 1984