toxicological profile for malathion - Agency for Toxic Substances and ...

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MALATHION C-1 APPENDIX C. ACRONYMS, ABBREVIATIONS, AND SYMBOLS ACOEM American College of Occupational and Environmental Medicine ACGIH American Conference of Governmental Industrial Hygienists ADI acceptable daily intake ADME absorption, distribution, metabolism, and excretion AED atomic emission detection AOEC Association of Occupational and Environmental Clinics AFID alkali flame ionization detector AFOSH Air Force Office of Safety and Health ALT alanine aminotransferase AML acute myeloid leukemia AOAC Association of Official Analytical Chemists AP alkaline phosphatase APHA American Public Health Association AST aspartate aminotranferase atm atmosphere ATSDR Agency for Toxic Substances and Disease Registry AWQC Ambient Water Quality Criteria BAT best available technology BCF bioconcentration factor BEI Biological Exposure Index BSC Board of Scientific Counselors C centigrade CAA Clean Air Act CAG Cancer Assessment Group of the U.S. Environmental Protection Agency CAS Chemical Abstract Services CDC Centers for Disease Control and Prevention CEL cancer effect level CELDS Computer-Environmental Legislative Data System CERCLA Comprehensive Environmental Response, Compensation, and Liability Act CFR Code of Federal Regulations Ci curie CI confidence interval CL ceiling limit value CLP Contract Laboratory Program cm centimeter CML chronic myeloid leukemia CPSC Consumer Products Safety Commission CWA Clean Water Act DHEW Department of Health, Education, and Welfare DHHS Department of Health and Human Services DNA deoxyribonucleic acid DOD Department of Defense DOE Department of Energy DOL Department of Labor DOT Department of Transportation
MALATHION C-2 APPENDIX C DOT/UN/ Department of Transportation/United Nations/ NA/IMCO North America/International Maritime Dangerous Goods Code DWEL drinking water exposure level ECD electron capture detection ECG/EKG electrocardiogram EEG electroencephalogram EEGL Emergency Exposure Guidance Level EPA Environmental Protection Agency F Fahrenheit F1 first-filial generation FAO Food and Agricultural Organization of the United Nations FDA Food and Drug Administration FEMA Federal Emergency Management Agency FIFRA Federal Insecticide, Fungicide, and Rodenticide Act FPD flame photometric detection fpm feet per minute FR Federal Register FSH follicle stimulating hormone g gram GC gas chromatography gd gestational day GLC gas liquid chromatography GPC gel permeation chromatography HPLC high-performance liquid chromatography HRGC high resolution gas chromatography HSDB Hazardous Substance Data Bank IARC International Agency for Research on Cancer IDLH immediately dangerous to life and health ILO International Labor Organization IRIS Integrated Risk Information System Kd adsorption ratio kg kilogram Koc organic carbon partition coefficient Kow octanol-water partition coefficient L liter LC liquid chromatography LCLo lethal concentration, low LC50 lethal concentration, 50% kill LDLo lethal dose, low LD50 lethal dose, 50% kill LDH lactic dehydrogenase LH luteinizing hormone LT50 lethal time, 50% kill LOAEL lowest-observed-adverse-effect level LSE Levels of Significant Exposure m meter MA trans,trans-muconic acid MAL maximum allowable level mCi millicurie MCL maximum contaminant level MCLG maximum contaminant level goal
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TOXICOLOGICAL PROFILE FOR MALATHION
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MALATHION iii UPDATE STATEMENT A To
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MALATHION viii Managing Hazardous M
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MALATHION xi PEER REVIEW A peer rev
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MALATHION xiv 3.2.3.2 Systemic Effe
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MALATHION xvii LIST OF FIGURES 3-1.
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MALATHION 1 1. PUBLIC HEALTH STATEM
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MALATHION 11 1. PUBLIC HEALTH STATE
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MALATHION 14 2. RELEVANCE TO PUBLIC
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MALATHION 24 3. HEALTH EFFECTS oral
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MALATHION 26 3. HEALTH EFFECTS sing
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≤
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MALATHION 30 3. HEALTH EFFECTS Resp
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MALATHION 32 3. HEALTH EFFECTS Rena
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MALATHION 34 3. HEALTH EFFECTS Stud
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MALATHION 36 3. HEALTH EFFECTS Fran
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MALATHION 38 3. HEALTH EFFECTS more
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MALATHION 40 3. HEALTH EFFECTS the
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a Key to figure 1 2 3 4 5 6 Species
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a Key to figure 15 16 17 18 Species
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a Key to figure 24 25 26 27 28 29 S
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a Key to figure 40 41 42 43 44 45 S
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a Key to figure 55 56 57 58 59 60 S
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a Key to figure 67 68 69 70 Species
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a Key to figure 83 84 85 86 87 88 8
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a Key to figure 91 Species (Strain)
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a Key to figure 93 94 Species (Stra
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≤
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≤
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MALATHION 64 3.2.2.2 Systemic Effec
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MALATHION 66 3. HEALTH EFFECTS 1965
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MALATHION 68 3. HEALTH EFFECTS Hepa
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MALATHION 70 3. HEALTH EFFECTS appr
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MALATHION 72 3. HEALTH EFFECTS an u
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MALATHION 74 3. HEALTH EFFECTS Meta
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MALATHION 76 3. HEALTH EFFECTS clas
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MALATHION 78 3. HEALTH EFFECTS was
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MALATHION 80 3. HEALTH EFFECTS appr
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MALATHION 82 3. HEALTH EFFECTS Clin
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MALATHION 84 3. HEALTH EFFECTS mala
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MALATHION 86 3. HEALTH EFFECTS Tera
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MALATHION 88 3. HEALTH EFFECTS for
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MALATHION 90 3. HEALTH EFFECTS sugg
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Species (Strain) Systemic Exposure/
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MALATHION 94 3. HEALTH EFFECTS Endo
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MALATHION 96 3. HEALTH EFFECTS Othe
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MALATHION 98 3. HEALTH EFFECTS derm
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MALATHION 100 3. HEALTH EFFECTS al.
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MALATHION 102 3. HEALTH EFFECTS of
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MALATHION 104 3. HEALTH EFFECTS per
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MALATHION 106 3.4.1.1 Inhalation Ex
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MALATHION 108 3. HEALTH EFFECTS was
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MALATHION 110 3. HEALTH EFFECTS fir
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MALATHION 112 3.4.2.3 Dermal Exposu
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MALATHION 114 3. HEALTH EFFECTS neu
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MALATHION 116 3. HEALTH EFFECTS aci
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MALATHION 118 3.4.4.1 Inhalation Ex
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MALATHION 120 3. HEALTH EFFECTS agr
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MALATHION 122 V E N O U S BLOOD 3.
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MALATHION 124 3. HEALTH EFFECTS Tab
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MALATHION 126 3. HEALTH EFFECTS mus
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MALATHION 128 3.5.2 Mechanisms of T
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MALATHION 130 3. HEALTH EFFECTS pla
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MALATHION 132 3. HEALTH EFFECTS In
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MALATHION 134 3. HEALTH EFFECTS Ove
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MALATHION 136 3. HEALTH EFFECTS are
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MALATHION 138 3. HEALTH EFFECTS whe
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MALATHION 140 3. HEALTH EFFECTS the
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MALATHION 142 3. HEALTH EFFECTS org
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MALATHION 144 3. HEALTH EFFECTS The
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MALATHION 146 3. HEALTH EFFECTS pla
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MALATHION 148 3. HEALTH EFFECTS org
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MALATHION 150 3. HEALTH EFFECTS stu
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MALATHION 152 3. HEALTH EFFECTS Par
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MALATHION 154 3. HEALTH EFFECTS exp
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MALATHION 156 3. HEALTH EFFECTS wer
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MALATHION 158 3. HEALTH EFFECTS who
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MALATHION 160 3. HEALTH EFFECTS Lee
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MALATHION 162 3. HEALTH EFFECTS res
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MALATHION 164 3. HEALTH EFFECTS inf
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MALATHION 166 3. HEALTH EFFECTS med
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MALATHION 168 4. CHEMICAL AND PHYSI
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MALATHION 171 5. PRODUCTION, IMPORT
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MALATHION 173 5. PRODUCTION, IMPORT
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MALATHION 175 6.1 OVERVIEW 6. POTEN
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MALATHION 177 6. POTENTIAL FOR HUMA
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MALATHION 187 6.3.2.1 Air 6. POTENT
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MALATHION 216 7. ANALYTICAL METHODS
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MALATHION 224 7.3.1 Identification
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MALATHION 226 8. REGULATIONS AND AD
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MALATHION 238 9. REFERENCES *Agency
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MALATHION 240 9. REFERENCES *Barnes
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MALATHION 242 9. REFERENCES *Brown
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MALATHION 244 9. REFERENCES *Choi P
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MALATHION 246 9. REFERENCES *De Ble
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MALATHION 248 9. REFERENCES Ehrich
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MALATHION 250 9. REFERENCES EPA. 20
Page 271 and 272: MALATHION 252 9. REFERENCES *Gaines
Page 273 and 274: MALATHION 254 9. REFERENCES *Harman
Page 275 and 276: MALATHION 256 9. REFERENCES Jianmon
Page 277 and 278: MALATHION 258 9. REFERENCES Kimbrou
Page 279 and 280: MALATHION 260 9. REFERENCES *Lechne
Page 281 and 282: MALATHION 262 9. REFERENCES *Mackis
Page 283 and 284: MALATHION 264 9. REFERENCES Mohn G.
Page 285 and 286: MALATHION 266 9. REFERENCES NIOSH.
Page 287 and 288: MALATHION 268 9. REFERENCES *Prabha
Page 289 and 290: MALATHION 270 9. REFERENCES *Roy RR
Page 291 and 292: MALATHION 272 9. REFERENCES *Singar
Page 293 and 294: MALATHION 274 9. REFERENCES *Thongs
Page 295 and 296: MALATHION 276 9. REFERENCES Viccell
Page 297 and 298: MALATHION 278 9. REFERENCES Yess NJ
Page 299 and 300: MALATHION 280 10. GLOSSARY Ceiling
Page 301 and 302: MALATHION 282 10. GLOSSARY Mutagen
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Page 305 and 306: MALATHION A-2 APPENDIX A are not ex
Page 307 and 308: MALATHION A-4 APPENDIX A Was a conv
Page 309 and 310: MALATHION A-6 APPENDIX A Was a conv
Page 311 and 312: MALATHION A-8 APPENDIX A If an inha
Page 313 and 314: MALATHION A-10 Uncertainty Factors
Page 315 and 316: MALATHION B-2 Interpretation of Min
Page 317 and 318: MALATHION B-4 APPENDIX B (8) NOAEL
Page 319 and 320: 1 2 3 4 12 → → → → → Key
Page 324 and 325: MALATHION C-3 APPENDIX C MFO mixed
Page 326: MALATHION C-5 > greater than $ grea
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