toxicological profile for malathion - Agency for Toxic Substances and ...

a
Key to
figure
90
Species
(Strain)
Exposure/
Duration/
Frequency
(Specific Route)
Systemic
Rat 2 yr
(Fischer- 344)
ad libitum
(F)
System
Hemato
Table 3-2 Levels of Significant Exposure to Malathion - Oral
NOAEL
(mg/kg/day)
35 F
Less Serious
LOAEL
Serious
(mg/kg/day) (mg/kg/day)
359 M (decreased hemoglobin,
hematocrit, MCV, and mean cell
hemoglobin)
Hepatic 35 F 359 M (increased absolute and relative
liver weight)
Renal 35 F 359 M (increased absolute and relative
kidney weight)
Endocr 35 F 415 F (increased absolute and relative
thyroid and parathyroid weight)
Ocular
868 F
Bd Wt 35 F 359 M (decreased body weight gain)
Other
868 F
(continued)
Reference
Chemical Form
Daly 1996a