toxicological profile for malathion - Agency for Toxic Substances and ...

a
Key to
figure
15
16
17
18
Species
(Strain)
Systemic
Rat
(Sprague-
Dawley)
Rat
(Sprague-
Dawley)
Rat
(Wistar)
Rat
(Wistar)
Exposure/
Duration/
Frequency
(Specific Route)
System
Table 3-2 Levels of Significant Exposure to Malathion - Oral
NOAEL
(mg/kg/day)
Less Serious
LOAEL
Serious
(mg/kg/day) (mg/kg/day)
(continued)
Reference
Chemical Form
once Lox 1983
Hemato
4.4 M (decreased hematocrit and
(GW)
platelet counts)
14 d
ad libitum
(W)
7 d
ad libitum
(F)
14 d
1 x/d
(GO)
Hemato
Bd Wt
111 F
89 F (changes in clotting factor
activity)
Other 89 F (30% decrease in water intake)
Resp
163
Cardio 411 593 (tachycardia)
Bd Wt 411 593 (17% decrease in weight)
Other 18.5 163 (12% decrease in food intake)
Resp
411 (severe respiratory distress)
130 M (interstitial pneumonia,
emphysema)
Cardio 130 M
390 M (focal hemorrhage in the heart)
Hepatic 130 M (diffuse hydropic degeneration)
Renal 130 M
(atrophy of the glomeruli;
degeneration of tubular
epithelium)
Lox 1985
Ojha et al. 1992
Piramanayagam and Manohar 2002