toxicological profile for malathion - Agency for Toxic Substances and ...

a
Key to
figure
93
94
Species
(Strain)
Systemic
Mouse
(B6C3F1)
Mouse
(B6C3F1)
Exposure/
Duration/
Frequency
(Specific Route)
80 wk
ad libitum
(F)
18 mo
ad libitum
(F)
95
Neurological
Rat
2 yr
(Fischer- 344)
ad libitum
(F)
System
Resp
Cardio
Gastro
Musc/skel
Hepatic
Renal
Endocr
Dermal
Table 3-2 Levels of Significant Exposure to Malathion - Oral
NOAEL
(mg/kg/day)
2980
2980
2980
2980
2980
2980
2980
Less Serious
LOAEL
Serious
(mg/kg/day) (mg/kg/day)
2980 (coughing and sneezing from
week 72 until end of study)
Bd Wt 1490 (>10% lower body weight than
controls)
Resp
17.4 M
167 F (increased incidence of
non-neoplastic nasal lesions)
Hepatic 167 F 1476 M (hepatocellular hypertrophy)
Bd Wt 167 F 1476 M (14-20% decreased body
weight)
Other 167 F 1476 M (decreased food consumption)
2 d M
29 e
M (29% inhibition of plasma
cholinesterase)
35 F (27% inhibition of RBC
cholinesterase)
(continued)
359 M (64% inhibition of plasma
cholinesterase)
Reference
Chemical Form
NCI 1978
Slauter 1994
Daly 1996a