toxicological profile for malathion - Agency for Toxic Substances and ...

MALATHION 103
Species (test system)
Prokaryotic organisms:
3. HEALTH EFFECTS
Table 3-5. Genotoxicity of Malathion In Vitro
End point
Results
With
activation
Without
activation
Reference
Salmonella typhimurium
(TA97a)
Gene mutation – – Pednekar et al. 1987
S. typhimurium (TA98) Gene mutation – – Pednekar et al. 1987
S. typhimurium (TA100) Gene mutation – – Pednekar et al. 1987
S. typhimurium (TA102) Gene mutation – – Wong et al. 1989
S. typhimurium (TA1535) Gene mutation – – Wong et al. 1989
S. typhimurium (TA1537) Gene mutation – – Wong et al. 1989
Bacillus subtillis (TKJ5211) Gene mutation – – Shiau et al. 1980
B. subtillis (TKJ6321) Gene mutation + ± Shiau et al. 1980
B. subtillis (rec assay) DNA damage ± ± Shiau et al. 1980
Isolated DNA from Escheria coli
K-12
Mammalian cells:
DNA damage NT + Griffin and Hill 1978
CHO cells Sister chromatid
exchange
NT + Nishio and Uyeki 1981
Human fetal fibroblasts Sister chromatid
exchange
NT + Nicholas et al. 1979
Human lymphoid cells Sister chromatid
exchange
+ + Sobti et al. 1982
Human lymphocytes Sister chromatid
exchange
+ + Garry et al. 1990
Human lymphocytes Sister chromatid
exchange
NT + Balaji and Sasikala 1993
Human lymphocytes Micronuclei NT ± Titenko-Holland et al.
1997
Human lymphocytes Chromosomal
aberrations
+ + Garry et al. 1990
Human lymphocytes Chromosomal
aberrations
NT + Balaji and Sasikala 1993
Human lymphocytes Chromosomal
aberrations
NT + Walter et al. 1980
Human lymphocytes DNA repair NT – Blasiak et al. 1999
Human lymphocytes Mutation
frequency
NT + Pluth et al. 1996, 1998
– = negative result; + = positive result; ± = weak positive result; CHO = Chinese hamster ovary; DNA = deoxyribose
nucleic acid; NT = not tested