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Vol. 60, 1909 - University of North Carolina at Chapel Hill

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effects <strong>of</strong> antitoxin tre<strong>at</strong>ment and these<br />

cases had best be avoided. Gewin, in a<br />

series <strong>of</strong> 200 p<strong>at</strong>ients given injections <strong>of</strong><br />

diphtheria antitoxin, gave every altern<strong>at</strong>e<br />

p<strong>at</strong>ient calcium, gr, 7 1-2 to 15, by mouth<br />

when the antitoxin was injected. He<br />

claims th<strong>at</strong> in those p<strong>at</strong>ients receiving the<br />

calcium chloride there was either no disturbance<br />

<strong>at</strong> all or, <strong>at</strong> the most, very slight.<br />

It would, therefore, perhaps, be wise to give<br />

calcium chloride with every injection <strong>of</strong><br />

antitoxin as a prophylactic measure, and,<br />

wherever possible, the administr<strong>at</strong>ion <strong>of</strong> the<br />

calcium chloride should precede the antitoxin.<br />

There is still much work to be done on<br />

this most important subject and the future<br />

will probably bring out many interesting<br />

points along this line. Rosenau and Anderson<br />

believe th<strong>at</strong> the results so far obtained<br />

show th<strong>at</strong> anaphylaxis has a practical<br />

significance in the prevention and<br />

cure <strong>of</strong> certain <strong>of</strong> the infectious diseases<br />

and th<strong>at</strong> this is true we hope may be shown<br />

in the nearby future.<br />

In conclusion, I wish to thank Dr. John<br />

F. Anderson <strong>of</strong> the Hygienic Labor<strong>at</strong>ory<br />

<strong>of</strong> the U. S. P. and M. H. Service for mucii<br />

valuable assistance in furnishing me with<br />

liter<strong>at</strong>ure and references.<br />

Bibliography<br />

Rosenau and Anderson, Journ. Infect.<br />

Dis., vol. 5, No. 1, Jan. 1808.<br />

Rosenau and Anderson, Rull. No. 20,<br />

Hyg. Lab., U.S. P. H. and M. II. Serv.,<br />

Washington, 1905.<br />

Rosenau and Anderson, Journ. Med.<br />

Res., 1906, 10, p. 179.<br />

Rosenau and Anderson, Journ. Am. Med.<br />

Assoc, 47, p. 1007, 1906.<br />

Rosenau and Anderson, Bull, No. 36,<br />

Hyg., Lab., U. S. P. H. and M. H. Serv.,<br />

Washington, 1906.<br />

Rosenau and Anderson, Journ. Res., p.<br />

381, 1907.<br />

R6senau and Anderson, Journ. Infect.<br />

Dis., 4, p. 552, 1907.<br />

John F. Anderson, Bull." No. 30, Hyg.<br />

Lab., U. S. P. H. and M. H. Serv., Washington,<br />

1906.<br />

John F. Anderson, Jour. Med. Res., 10,<br />

p. 241, 1996.<br />

John F. Anderson, Ibid, 259.<br />

Ricketts, Infection, Immunity and Serum<br />

Therapy.<br />

H. R. M. Landis, Progress. Med., <strong>Vol</strong>.<br />

10. No. 4, Dec, 1908.<br />

Knorr, Habilit<strong>at</strong>iouschrift, 31pp., 8 pis.,<br />

800, Marbourg, 1905.<br />

Hericourt and Richett, Com. rend. soc.<br />

biol., .53, p. 137, 1898.<br />

Behring and Kitashima, Berl. klin.<br />

Woch., 38, p. 157, 1901.<br />

.<br />

ORIGINAL COMMUNICATIONS. 95<br />

Portier and Richet, Compt. rend, sec<br />

Biol. 54, p. 170, 1902.<br />

Arthus, Ibid., 55, p. 817, 1903.<br />

Richet, Arch, difisiol.. 1, p. 129, 1904.<br />

Richet, Compt. rend. soc. biol., 58, p,<br />

109, 1905.<br />

Richet, Ibid., p. 112.<br />

Dr. C. Von Pirquet and Dr. B. Schick<br />

Die Serumkrankheit, Leipzig, 1905.<br />

R. Otto, Das Theobald Smithsche Phan<br />

omen der Serumueberumpfindlichkelt. v<br />

Leuthold-Gedenschrift, 1 Band, 1905.<br />

McClintock and King, Journ. Infect<br />

Dis., 3, p. 700, 1906.<br />

Currie, Journ. Hyg. 7, p. 35, 1907.<br />

Besredka and Steinhart, Ann. de ITnst<br />

Past., 21, p. 117, 1907.<br />

Xicholle, Ibid., p. 128.<br />

Besredka, Compt. rend. soc. biol'., 62, p<br />

447, 1907,<br />

Besredka, Ibid., p. 1053.<br />

Besredka and S'einhardt, Ann. de I'lnst<br />

Past., 21, p. 3S4.<br />

Besredka, Ibid., p; 777.<br />

Besredka, Revue Medico-Sociale,2, p. 10,<br />

1908.<br />

Vaughan, Journ. Am. Med. Assoc, 47,<br />

p. I(tn9.<br />

\'aughan and Wheeler, Journ. Infect.<br />

Dis., 4, p. 476, 1907,<br />

Gay and Southard, Journ. Med. Res.,<br />

16, p. 143, 1907.<br />

Otto, Munch. Med. Woch., 55, p. 1665,<br />

1907.<br />

Richet, Ann. de I'inst. Past., 21. p. 497,<br />

1907.<br />

Goodall, Journal. Hyg., 7, <strong>60</strong>7, 1907.<br />

Uhlenhuth, Dent. Med. Woch., 26, p.<br />

734, 1900.<br />

Metalnik<strong>of</strong>f, Centralbl. f. Bakt., 29, p.<br />

531, 1901.<br />

Vallee, Med. Vet., 84 p. 308.<br />

Petet, Compt. rend. soc. biol., 63, p.<br />

296, 1907.<br />

Landis, Therapeutic Gazette, Nov., 1908.<br />

W<strong>at</strong>erhouse, British Med. Journ., Apr.<br />

18, 1908.<br />

Wiley, Journ. Am. Med. Assoc, Jan.,<br />

11, 1908.<br />

Schmitt, Ibid., Feb. 22, 1908.<br />

Boone, Ibid., Feb. 8, 1908.<br />

Gillette, Ibid., Jan. 4, 1908.<br />

Quigley, Ibid., Mch. 7, 1907.<br />

Dreyfoos, Ibid., Sept. 5, 1908.<br />

Thomas, Ibid., July 4, 1908.<br />

F. L. Taylor, Med. Record, July 4, 1907.<br />

Blain, Ibid., June 6, 1908.<br />

Royer, Therapeutic Gazette, June, 1908.<br />

Gewin, Munch, med. Woch., 51, p.<br />

2670. 1908.

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