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Vol. 60, 1909 - University of North Carolina at Chapel Hill

Vol. 60, 1909 - University of North Carolina at Chapel Hill

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Abstracts <strong>of</strong> the Leading articles<br />

<strong>of</strong> the month.<br />

Radioactivity and Carcinoma.—Barlow,<br />

in The British Medical Journal, says<br />

th<strong>at</strong> the original question with which he<br />

started—namely, Do the physical agents<br />

which are commonly supposed to give rise<br />

to cancer (clay pipes, soot, etc. \ and do<br />

samples <strong>of</strong> carcinom<strong>at</strong>ous m<strong>at</strong>erial afford<br />

evidence <strong>of</strong> the possession <strong>of</strong> radioactive<br />

properties?—is not conclusively answered.<br />

In certain respects they behave like the<br />

radioactive m<strong>at</strong>erials <strong>of</strong> the chemist or<br />

physicist, but in no single instance do they<br />

respond to all the criteria <strong>of</strong> recognized<br />

radioactivity. The author says th<strong>at</strong> many<br />

<strong>of</strong> the substances affect a photographic<br />

pl<strong>at</strong>e in the dark; but, on the other hand,<br />

few can act on the pl<strong>at</strong>e if a screen is interposed,<br />

and even in those instances in which<br />

a positive result is obtained under these circumstances,<br />

tt is doubtful whether the interposed<br />

celloidiu screen is fairly so called.<br />

Nevertheless, it is doubtful whether the<br />

power <strong>of</strong> acting through a screen is a necessary<br />

criterion <strong>of</strong> radioactivity, since he has<br />

demonstr<strong>at</strong>ed th<strong>at</strong> albuminous compounds<br />

<strong>of</strong> recognized radioactive substances may<br />

possess a power <strong>of</strong> acting on the photographic<br />

pl<strong>at</strong>e which will not traverse an<br />

extremely thin screen, and, indeed, may be<br />

devoid <strong>of</strong> photographic powers altogether.<br />

In the l<strong>at</strong>ter respect they are comparable<br />

with clay pipe, inasmuch as neither type <strong>of</strong><br />

substance acts on a photographic pl<strong>at</strong>e and<br />

both acceler<strong>at</strong>e the discharge <strong>of</strong> an electroscope.<br />

In the same c<strong>at</strong>egory comes carcinoma<br />

m<strong>at</strong>erial which has been extracted<br />

with acetone or with w<strong>at</strong>er and subsequently<br />

with ether. Possibly, too, some specimens<br />

<strong>of</strong> spleen and <strong>of</strong> the inorganic constituents<br />

<strong>of</strong> bone are to be reckoned in the<br />

same class. He takes up the cancer question,<br />

and speaks <strong>of</strong> the different parts <strong>of</strong><br />

the body <strong>at</strong>tacked by carcinoma. The<br />

writer mentions the theory th<strong>at</strong> it is possible<br />

th<strong>at</strong> the radioactivity is the common<br />

factor which must be capable <strong>of</strong> stimul<strong>at</strong>ing<br />

the growth <strong>of</strong> certain cells while it depresses<br />

the growth <strong>of</strong> others, which must<br />

reside in substances <strong>of</strong> the widest diversity,<br />

which must act with varying intensities in<br />

different cases though always with compar<strong>at</strong>ive<br />

slowness, the n<strong>at</strong>ural action <strong>of</strong><br />

which must be progressive so long as it<br />

persists. The x-rays cause carcinoma, they<br />

stimul<strong>at</strong>e ( like other radioactive substances)<br />

the growth <strong>of</strong> cells, and, again, they retard<br />

the growth <strong>of</strong> cells, carcinom<strong>at</strong>ous m<strong>at</strong>erial,<br />

noncarcinom<strong>at</strong>^us m<strong>at</strong>erial, extracts <strong>of</strong> animal<br />

tissues, various substances usually regarded<br />

as casually rel<strong>at</strong>ed to carcinoma,<br />

THE CHARLOTTE MEDICAL JOURNAL.<br />

possess properties resembling those <strong>of</strong> recognized<br />

radioactive substances to a gre<strong>at</strong>er or<br />

less degree when considered from the<br />

physicist's point <strong>of</strong> view, and there is evidence<br />

th<strong>at</strong> hey possess powers <strong>of</strong> stimul<strong>at</strong>ing<br />

or depressing the division <strong>of</strong> animal<br />

cells. Such similarities are <strong>at</strong> least suggestive.<br />

Tre<strong>at</strong>ment ol Incoercible Vomiting <strong>of</strong><br />

Pregnancy.—Wallich (Ann. de Gyn. et<br />

d'Obst. ) mentions the three classical diets<br />

in vomiting <strong>of</strong> pregnancy as, milk diet,<br />

w<strong>at</strong>er diet, and lactovegetable diet. Pinard<br />

advises the milk diet whenever we have the<br />

symptoms <strong>of</strong> autointoxic<strong>at</strong>ion, only a small<br />

dose <strong>of</strong> milk being .given <strong>at</strong> a time. If we<br />

find th<strong>at</strong> these small doses are well borne,<br />

then the amount <strong>of</strong> milk taken is to be increased.<br />

If the urine increases, and vomiting<br />

ceases a cure is obtained: but in some<br />

cases even small doses <strong>of</strong> milk cannot be<br />

retained, ^^'e must then give only w<strong>at</strong>er,<br />

in small doses. This diet cannot be persisted<br />

in for more than four to eight days,<br />

since it is the diet <strong>of</strong> inanition. At the end<br />

<strong>of</strong> some days a small amount <strong>of</strong> milk is<br />

added to the w<strong>at</strong>er and the p oportion <strong>of</strong><br />

milk gradually increased. When the w<strong>at</strong>er<br />

diet is not well borne, all feeding by stomach<br />

must cease for twenty-four to fortyeight<br />

hours. Subcutaneous injections <strong>of</strong><br />

serum are made <strong>at</strong> the same time to replace<br />

the w<strong>at</strong>er withdrawn from the system in the<br />

urine and feces. Another diet th<strong>at</strong> has<br />

been proposed consists <strong>of</strong> farino-vegetable<br />

soups and purees, which produce no poisons,<br />

but these substances are not better<br />

borne than milkr Calming drugs must be<br />

given <strong>at</strong> the same time. Inhal<strong>at</strong>ions <strong>of</strong><br />

oxygen lessen the number and severity <strong>of</strong><br />

the vomiting <strong>at</strong>tacks. If the urine incveases<br />

in amount and vomitin.g ceases, all will be<br />

well. We must not wait too long while<br />

using these measures, but if they fail should<br />

have recourse to the induction <strong>of</strong> abortion.<br />

When there is an acceler<strong>at</strong>ion <strong>of</strong> the pulse<br />

and fever, it is time to use obstetrical interference.<br />

In some cases the cause <strong>of</strong> the<br />

vomiting is uterine or ovular, and in these<br />

cases only abortion will do any good.<br />

Marriage <strong>of</strong> Women Having Cardiac<br />

Diseases.— Renon (Gaz. des Hop. i believes<br />

th<strong>at</strong> the question <strong>of</strong> whether a woman<br />

having cardiac disease should marry is to<br />

be determined by the form and extent <strong>of</strong>'<br />

th<strong>at</strong> disease. Many women having wellmarked<br />

cardiac disease pass successfully •<br />

through a number <strong>of</strong> pregnancies. The<br />

question whether there are changes in the'<br />

arterial tension and kidney condition is im-^<br />

portant. If there be constant alter<strong>at</strong>ions<br />

in the tension <strong>of</strong> the pulse, marriage should;<br />

be avoided. The kinds <strong>of</strong> trouble to which!

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