Vol. 60, 1909 - University of North Carolina at Chapel Hill

ADVERTISEMKKTS, 4,37
A S-Pheu, formerly kuowu as Ther- "Proitssor Hks^x (
Berichle der Deutschen
mol, has been proven by extensive chemi- GeselL, Vol. 37, p. 3076), states: "in the
cal and clinical tests, to be of potent and matter of reducing temperature the anilides
reliable therapeutic value. work better than the phenetides; but even in
The abbreviation—a-s-pheu—explains small doses they develop quite early the un-
the nature of its composition—acetyl-^ali- desirable change of oxyhemoglobin into
cy\phenti\dLm. It is free from suggesting methahemoglobin, which appear as cyano-
its therapeutic application and any tend- sis. The phenetidin product, substituted
eucy to commercialize. with acetyl-salicylic acid (a s-pheu or
"This compound, which is not a thermol), proved inactive even in large
pharmaceutical, is so intimately encapsul- doses (0.4 grams*"—where there was no
ated by chemical condensation that it un- temperature.
dergoes gradual cleavage in the living body Professors Anschutz and Bertram, in the
and by the even supply, as it were, of its same publication, state; "The firmness
active component parts, doubtless exerts its with which the acetyl group is confined
full therapeutic value within the body, into this substance is to be noted."
without unduly disturbing the stomach, Br. W. D. Hamaker, secretary of the
depressing the heart's action or impairing Pennsylvania Medical Examining Board,
the pliysif logical integrity of the blood states: "With a-s phen I have been able
which so commonly follows the use of t'' reduce the time of treaMnent of typhoid
other salicylic and phenetidin compounds
• •
,
J .J ,.
when given in adequate doses.
fever one-half—except in very rate cases—
with entire safety to the circulation and res-
. . , ^
piration. In the future I shall treat pneu
A-S-Phen relieves headache, neuralsia, ^j^,,;^ with it."
catarrh, is useful in the disorders of men- Dr. Eugene B. Glenn (Surgeon with rank
struation, as a nerve calmative,
grippe, whooping cough, etc.
and in la of Major, National Guard of North Caro-
''"a): "Am using a-s-phen for the removal
AS Phen possesses antiseptic effect
''^ ^^''^' '" "^^ tuberculosis cases: and with-
. , ., . , out any signs of sweating as th; result of
on the urine. It serves to inhibit the . ^ ^, ...
the use of the medicine,
formation of fever: (1) By retarding through
^r. Henry Beates, Jr., president of the
its antisef>tic jjroperties the rapid growth of Pennsylvania Medical Examination Board,
the specific bacteria: (2) By its diaphoretic states: "I use a-s-phen (thermol) in those
and diuretic action and the consequent types of infectious disease like typhoid fev-
elimiiiation of the toxins; (3) By its ver, in those cases where the purin bases are
nerve sedative influence on the heat-regu- evolved in excess like rheumatic and kin-
latiiig powers of the nervous system and dred disorders, and in that other class of
the retarding of tissue waste. disease for which the salicyl group is indi-
Prof. Samuel P. Sadtler, Ph. D., LLD., cated, and where I have found it as reliable
and his son, Samuel S. Sadtler, S. B., state: as is quinine in malaria. I also use it in
We verified the composition of a-s-phen neuralgia as a nerve sedative and in those
qualitatively and quantitatively, which catarrhal conditions so symptomatic of the
clearly identified it and established its so-called uric acid or gouty diathesis. I
proximate composition, and found it tobea believe this product to be one of the most
definite synthetic compound—acetyl-salicyl valuable compounds ever created by man."
phenetidin, whose formula is C8H4 (OC-2- Send SI for fifty .5-grain capsules and a
HaO) CO.NiI.C,,H4 (OC.H.-,) or CirH; one-minute high grade clinical thermoine-
NOj This composition was established by ter to the Organic Chemical Manufacturing
f A.nsch\i\.z a.\\A}iQXUdiva. Berichie der Chem. Company. 2559 North Sydenham street,
Gesell. 37, p. 3975)." Philadelphia, Pa.