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Vol. 60, 1909 - University of North Carolina at Chapel Hill

Vol. 60, 1909 - University of North Carolina at Chapel Hill

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ORIGINAL COMMUNICATIONS.<br />

to administer morphia hypodermically; if it<br />

is only slight, it may be relieved with chlor<strong>of</strong>orm<br />

w<strong>at</strong>er and bismuth or some <strong>of</strong> the<br />

milder anodynes.<br />

Where perfor<strong>at</strong>ion has occurred, a surgical<br />

oper<strong>at</strong>ion is the only hope <strong>of</strong> saving the<br />

p<strong>at</strong>ient's life. Where there is a slight but<br />

constant bleeding which does not respond<br />

readily to rest and tre<strong>at</strong>ment, surgical intervention<br />

is indic<strong>at</strong>ed.<br />

Typhoid Fever. Importance ol Early<br />

Diagnosis —Fasting — Special Diet —<br />

Surgical Rest <strong>of</strong> Bowel ~ and<br />

Simplicity <strong>of</strong> Tre<strong>at</strong>ment.<br />

By Dr. A. J. Burkholder, Mt. Sydney, Va.<br />

This disease has a very interesting history,<br />

and was for several centuries confused<br />

with typhus fever. Ancient writers describe<br />

in part wh<strong>at</strong> we recognize as typhoid; but<br />

to a physician <strong>of</strong> this country justly belongs<br />

the distinction <strong>of</strong> first differenti<strong>at</strong>ing, and<br />

setting forth clinically and p<strong>at</strong>hologically<br />

this fever as a separ<strong>at</strong>e and distinct d.sease.<br />

F.om American sources even today we are<br />

able to study this disease with gre<strong>at</strong>er s<strong>at</strong>isfaction<br />

than from foreign observers.<br />

The time allotted will not permit <strong>of</strong> a discussion<br />

<strong>of</strong> the complex manifest<strong>at</strong>ions and<br />

types <strong>of</strong> infection, modes <strong>of</strong> entrance, systemic<br />

effect, and complic<strong>at</strong>ions. Therefore<br />

we will confine this brief to the consider<strong>at</strong>ion<br />

<strong>of</strong> a few points found in the sick room<br />

—leaving those winged questions until our<br />

aeroi^lane is sufficient there<strong>of</strong>.<br />

With the advancement <strong>of</strong> medical science<br />

we are able to delve into the depths <strong>of</strong> mystery,<br />

defy disease by immuniz<strong>at</strong>ion and antitoxin.<br />

Vet we must not forget th<strong>at</strong> njany<br />

<strong>of</strong> these valuable agents are only in their<br />

infancy <strong>of</strong> development, and many <strong>of</strong> the<br />

valuable tests employed in diagnosis are<br />

not infallible, are confirm<strong>at</strong>ory if positive,<br />

and if neg<strong>at</strong>ive in no wise proves th<strong>at</strong> disease<br />

does not exist. The time has not yet<br />

arrived, and never will, when we can in<br />

our labor<strong>at</strong>ory diagnose the p<strong>at</strong>ient. Th<strong>at</strong><br />

is wh<strong>at</strong> we propose to tre<strong>at</strong>, therefore let's<br />

come down. With the adv'ancement <strong>of</strong> our<br />

pr<strong>of</strong>ession, there is a growing tendencx- to<br />

wander away from convictions <strong>of</strong> bedside<br />

study. Yet wh<strong>at</strong> evidence has been produced<br />

to show th<strong>at</strong> the clinical conclusions<br />

<strong>of</strong> eighty-five years ago should be displaced<br />

by the observ<strong>at</strong>ions <strong>of</strong> today? The longtail<br />

co<strong>at</strong>, the solemn face, the silent tread,<br />

the modul<strong>at</strong>ed tone, the lancet and depleting<br />

measures have gone, and with them the<br />

impression pl<strong>at</strong>e, bedside diagnosis. The<br />

clinical picture <strong>of</strong> typhoid fever as drawn<br />

by Chapman, by Wood, and by Thompson<br />

eighty-odd years ago stands as a living<br />

monument today to those pr<strong>of</strong>ound students;<br />

and when compared with our most recent<br />

writings, those not yet dry from the printer's<br />

ink, they define clearly in every line those<br />

diagnostic symptoms observed <strong>at</strong> the bedside,<br />

upon which alone they depended.<br />

We would here enter a plea for a closer<br />

clinical study <strong>of</strong> disease, especially typhoid<br />

fever; for upon an early diagnosis, immedi<strong>at</strong>e<br />

in many cases, depends the life <strong>of</strong> the<br />

p<strong>at</strong>ient. Even where the least suspicion<br />

exists it should be regarded typhoid and<br />

tre<strong>at</strong>ed as such until you go and develop<br />

your cultures, search through available<br />

liter<strong>at</strong>ure, and make several m<strong>at</strong>hem<strong>at</strong>ical<br />

calcul<strong>at</strong>ions as to possibilities. These means<br />

<strong>of</strong> diagnosis are to our credit. Yet let us<br />

not forget th<strong>at</strong> too <strong>of</strong>ten valuable time is<br />

lost. The life <strong>of</strong> the p<strong>at</strong>ient and our success<br />

demands th<strong>at</strong> we act then and there<br />

no future time <strong>of</strong>fered. To do this requires<br />

a higher degree <strong>of</strong> trained powers <strong>of</strong> observ<strong>at</strong>ion;<br />

and such should be our aim, our<br />

first and main dependence.<br />

—<br />

Years ago—and so it is today universally<br />

admitted th<strong>at</strong> the food factor is one <strong>of</strong> the<br />

most important questions to be solved,<br />

livery writer and every practitioner holds<br />

to his own belief, however, all with varying<br />

degree <strong>of</strong> success. Many claiming th<strong>at</strong><br />

in the event such diet produces disorder it<br />

should be withdrawn. The most n<strong>at</strong>ural<br />

question suggested by th<strong>at</strong> direction is this:<br />

l)y withdrawing the <strong>of</strong>fending agent, can<br />

you also always withdraw tht evil effect<br />

l)roduced? If such diet is competent <strong>of</strong><br />

producing disorders, is it r<strong>at</strong>ional to employ<br />

it in a single case? Withdrawn, after the<br />

stomach rebels, after the cripjiled bowel<br />

has been unduly excited, after mixed infection<br />

has been favored, after the toxic system<br />

has been borne down to the very brink<br />

<strong>of</strong> the grave by increased sepsis, after the<br />

\ital forces have lost all power <strong>of</strong> resistance,<br />

after cell activity ceases from pr<strong>of</strong>ound<br />

toxemia? And, we might add, after distention<br />

favors a long list <strong>of</strong> dangers.<br />

Th<strong>at</strong> life-giving fluid th<strong>at</strong> stands par excellence<br />

hermetically sealed, transposed by<br />

transfusion, possessing all the nutritive elements,<br />

the proxim<strong>at</strong>e principals, kind for<br />

kind, gives abundant evidence <strong>of</strong> its utility<br />

in its n<strong>at</strong>ural sphere. This connecting link<br />

th<strong>at</strong> spans the chasm from darkness to light<br />

ceases to be food <strong>at</strong> a certain period. N<strong>at</strong>ure<br />

so says. We will jj<strong>at</strong>iently await evidence<br />

to the contrary.<br />

Let's leave <strong>of</strong>f the milk and give beef<br />

bullion, possibly we will grow a better<br />

culture.<br />

In the administr<strong>at</strong>ion <strong>of</strong> drugs we consider<br />

the physiological action, the therapeutical<br />

action, and the toxic action; and<br />

we are very careful to carefully guard the

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