PRINCIPLES OF TOXICOLOGY

580 INDEX
Children’s health status (continued)
lead-based paint case study, 549-552
Chironexfleckeri, venom toxicology, 428429
Chloestyramine, organochlorine insectide exposure
treatment, 353
Chloracne, dermal toxicity, 164
Chlorate salts, hematotoxicity and, 999100
Chlordecone, male reproductive toxicology and 217
Chloride ions, action potential mechanisms, 146-147
Chlorine:
pulmonary edema and, 183-l 84
pulmonotoxicity and dose-response relationships,
181
Chloroform:
inhalation, toxicity studies, 10
nephrotoxicity, 140
toxicology, 395-397
Chloromethane, toxicology, 393-397
Chlorophenoxy herbicides, structure and properties,
355-357
Chloroprene, spontaneous abortion and 227
Chlorothalonil, structure and toxicity, 359
Chlorpromazine, sperm cell development, cell-type
specific toxicity, 214
Cholangiocarcinomas, hepatoxicity and, 123
Cholangiofibromas, hepatoxicity and, 123
Cholera toxin, toxicology, 416
Cholestasis, hepatotoxicity and, 122
Cholinesterase levels, biological monitoring,
organophosphate/carbamate pesticides,
350-351
Chromatid exchange hypothesis, chromosomal
aberrations, 25 1
Chromium:
carcinogenicity of, 333-334
dermal exposure to, 330
toxicology of, 3399340
Chromosomes:
aberrations in, 250-25 1
germ cell assays of, 254
mutagenicity testing of, Drosophila assays, 253
structure and function, genetic toxicology and, 244
Chronic active hepatitis, cirrhosis and, 123
Chronic animal bioassay, chemical carcinogens,
2899290
Chronic beryllium disease, mechanisms of, 337-338
Chronic exposure:
defined, 4
metals toxicity, 331, 333
organochlorine insectides, 353
organophosphate/carbamate pesticides, 349
Chronic toxicity, defined, 4
Ciguatoxin, in fish venom, 426
Cirrhosis, hepatotoxicity and 123
Clastogenic chemicals, defined, 273
Clear cell adenocarcinomas, diethylstilbestrol (DES)
toxicity and 2299230
Clinical signs:
neurotoxicity, 152-l 53
occupational health practice and examination of,
5033504
Clinical toxicology:
as research discipline, 6
toxicity data in studies of, 12
Clomiphene citrate, female reproductive toxicology,
2222223
Clotting factors:
anticoagulant action and, 108
hepatoxicity and 125
Cluster determinants, T cell formation, 95
Cnidarian venoms, toxicology 428429
Cobalt, dermal exposure to, 330
Cocarcinogens, defined, 268
Coelenterate venoms, toxicology, 428429
Coenzyme A, biotransformation, amino acid
conjugation and methylation, 74
Cognitive function, lead poisoning research and,
235-236
Cohort studies, epidemiologic studies as, 517
Colony forming unit-erythrocyte (CFU-E), red blood
cell development, 91-92
Commercial secrets, ethics concerning, 508
Comparative risk analysis, procedures for, 468472
Competitive inhibition, xenobiotic metabolism,
77-79
Complement, immunotoxicity and, 1922193
Component toxicity, risk evaluation using, 465468
Concentration data, risk assessment studies, exposure
pathways and dosages, 446449
Confidentiality issues, for occupational health
practices, 507
Confounding bias, in epidemiologic studies, 5 19
Congenital defects:
developmental toxicology and, 224-232
embryonic and fetal toxic responses and, 228-23 1
suspected toxicants and teratogens, 23 l-232
Coniine, toxicology of, 421
Conjugation products, biotransformation, 83-85
Conjunctivitis, toxicity mechanisms, 193
Conservatism in risk assessment:
occupational health hazards control, 534-536
regulatory issues, 439440
Contact dermatitis. See Dermatitis
Control technologies:
carbon dioxide exposure studies, 547-549
occupational health hazards, 536-541
administrative controls, 540
exhaust and ventilation systems, 538-540
protective equipment and respirators, 540-541
source isolation, 538
substitution and process modification, 537-538
worker isolation, 538
Conus venom, toxicology of, 427428
Convallaria, digitalis compounds in, 3 9
Cooking techniques, diet and carcinogenicity,
316-317
Copper compounds:
in fungicides, 360