Catalogue of Research Groups from Moldova - WBC-INCO Net

SEVENTH FRAMEWORK
PROGRAMME
THE LABORATORY OF ORGANIC SYNTHESIS
Organization activity type : RES
FP7 theme : KBBE
Contact person : Dr. Fliur Macaev
Address : The Institute of Chemistry of ASM
3, Academiei street
MD2028 Chisinau
Republic of Moldova
E-mail : flmacaev@cc.acad.md
webpage : www.chem.md
THE INSTITUTE OF CHEMISTRY OF THE ACADEMY OF SCIENCES
BRIEf dESCRIpTIon of ThE oRganIzaTIon
The Laboratory of Organic Synthesis was founded in 1959. The research of the laboratory has been
oriented towards the creation of scientific bases of modern technologies with the view of obtaining
compounds necessary for medicine, agriculture, food industry, chemical industry and other fields
of human activity. The following important results in the field of development of organic synthesis
fundamentals are worth mentioning : elaboration of methods, reagents, solvents - “ionic liquids” and
organocatalysts, construction of polyfunctional open chain structures, of carbo- and heterocycles.
KEywoRdS on CoRE CompETEnCIES
Ionic liquids; catalysts for asymmetric synthesis; regio- and stereoselective reactions; biologically active
products.
ExpERTISE / CompETEnCIES / TEChnologIES / RTd Know-how
The laboratory is specialized in various aspects of organic and medicinal chemistry and is currently
engaged in projects directed towards : the discovery of new catalysts (metal-mediated and metal-free)
for asymmetric synthesis; mechanistic investigations of reactions which proceed with high levels of regioand
stereoselectivity; ionic liquids as green alternatives to solvents and the total synthesis of biologically
active products with the use of computer-aided molecular design and structure-activity analysis. Total
synthesis of biologically active products using computational methods of prognosis of biological activity.
InTERnaTIonal CoopERaTIon ExpERIEnCE
International cooperation projects :
• The Royal Society International Joint Program „Asymmetric synthesis of HIV-1 non-nucleoside
reverse transcriptase inhibitors”;
• INTAS projects Ref. № 2000-0711 and Ref. № 2006-8064;
• MD-Germany project Ref. № 09.820.05.08 GF;
• SCOPES, Ref. Nr.110823;
• MD-US projects CRDF/MC2-3007 and CRDF/MERL-7031,
• MD-Russia project - Ref. № 06.21CRF,
• MD-Belarus project Ref. № 05.15BF,
• MD-Ukraine project Ref. № 10.820.09.01/UA.
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