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Full Report - Research for Development - Department for ...

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Tukur (2010)<br />

(-)/(-)<br />

Women with<br />

eclampsia<br />

Labour (including induction)<br />

Abdul (2007)<br />

(-)/(+)<br />

Bergsjo<br />

(1989)<br />

(-)/(-)<br />

Women needing<br />

induction<br />

Women with<br />

uncomplicated<br />

pregnancies going<br />

beyond 42 weeks<br />

gestation<br />

Magnesium sulphate was administered<br />

following the Zuspan regimen (in which the<br />

maintenance doses are given<br />

intravenously).<br />

Induction of labour by misoprostol<br />

(intravaginal 50 microg. 6-hourly to a<br />

maximum of four doses) or oxytocin<br />

(maximum of 48 iu/min).<br />

Induction of labour by stripping of<br />

membranes and intravenous. oxytocin<br />

infusion, with artificial rupture of<br />

membranes when the cervical opening was<br />

3 cm or more in diameter. The control<br />

group was followed with clinical,<br />

biochemical and electronic tests,<br />

intervention being applied according to<br />

needs.<br />

Maternal<br />

mortality<br />

Perinatal<br />

mortality<br />

Maternal<br />

mortality<br />

Stillbirth<br />

Neonatal<br />

mortality<br />

Appendix 4.1<br />

This study is in support of the findings<br />

that magnesium sulphate is superior to<br />

diazepam in the reduction of maternal<br />

morbidity and mortality. However, the<br />

benefit to the infant was not<br />

statistically significant.<br />

No case of maternal mortality was<br />

recorded. The efficacy of misoprostol in<br />

the induction of third trimester labour is<br />

comparable to oxytocin.<br />

Maternal complications and perinatal<br />

morbidity rates were equally distributed<br />

between the groups. There was one<br />

perinatal death in the induction group<br />

and two deaths among the controls. No<br />

advantage of induction shown.<br />

What are the effects of different models of delivery <strong>for</strong> improving maternal and infant health outcomes <strong>for</strong> poor people in urban areas in low income<br />

and lower middle income countries?<br />

198

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