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Full Report - Research for Development - Department for ...

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Author<br />

(year)<br />

(IV)/(EV)<br />

Benn<br />

(2010)<br />

(++)/(++)<br />

Garly<br />

(2003)<br />

(+)/(-)<br />

Garly<br />

(2004)<br />

(+)/(++)<br />

Fetuga<br />

(2010)<br />

(+)/(+)<br />

Target<br />

Population<br />

Low birthweight<br />

neonates<br />

Neonates in<br />

general<br />

Infants in<br />

general<br />

Infants in<br />

general<br />

Neonates in<br />

general<br />

Brief intervention description Targeted<br />

outcome(s)<br />

Infant VAS. Infants were administered 50,000<br />

IU vitamin A or placebo and followed to 12<br />

months.<br />

Infant<br />

mortality<br />

BCG vaccine. Infant<br />

mortality<br />

Hepatitis B vaccine (HBV) alongside measles<br />

vaccine.<br />

Expanded Programme on Immunization (EPI)<br />

and the National Programme on Immunization<br />

(NPI).<br />

Infant<br />

mortality<br />

Neonatal<br />

tetanus (NNT)<br />

case fatality<br />

Findings summary<br />

Appendix 4.2<br />

VAS at birth was not significantly<br />

associated with infant mortality among low<br />

birthweight neonates. A significant<br />

association was revealed between VAS and<br />

gender,: mortality decreased in boys but<br />

increased in girls.<br />

BCG-vaccinated children with a BCG scar<br />

had significantly lower mortality compared<br />

with BCG scar-negative children in the first<br />

12 months of follow-up. The effect of BCG<br />

vaccination could be due to non-specific<br />

immune stimulation protecting against<br />

other infections.<br />

Among children enrolled in a measles<br />

vaccination trial, HBV-vaccinated children<br />

7½-12 months of age had higher mortality<br />

than cohorts that had not received HBV,<br />

the difference being particularly strong <strong>for</strong><br />

girls.<br />

Although the percentage prevalence of<br />

neonatal tetanus was lower in the later NPI<br />

period, the case fatality rate <strong>for</strong> the NPI<br />

period was higher than <strong>for</strong> the EPI period.<br />

The prevalence and mortality of NNT<br />

remains high in Nigeria despite a change in<br />

immunisation programme.<br />

What are the effects of different models of delivery <strong>for</strong> improving maternal and infant health outcomes <strong>for</strong> poor people in urban areas in low income<br />

and lower middle income countries?<br />

212

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