Full Report - Research for Development - Department for ...

Bergstrom
(1991)
(+)/(+)
Women with
preterm rupture of
membranes
Active management of third stage of labour
Afolabi
(2010)
(+)/(-)
Antimalarial
Kietinun
(1993)
(-)/(-)
Women in labour
with term
pregnancies and
having vaginal
delivery
Pregnant women
with malaria
The intervention group received amoxicillin
(100mg) and metronidazole (500mg), both
drugs given three times daily. All patients
were also routinely treated with an
antimalarial dose of chloroquine. The
control group was not given any
pharmaceutical treatment, and labour was
induced 3-24h after membrane rupture.
Use of misoprostol in active management of
third stage of labour to prevent primary
postpartum haemorrhage. Group 1 received
oral misoprostol. Group 2 received
intramuscular oxytocin.
Malaria cases were treated with a loading
dose of quinine hydrochloride given
intravenously at 20mg/Kg diluted in 250 ml
5% dextrose in four hours, and then doses
of 10 mg/Kg given at intervals of eight
hours with the same dilution and rate until
the patients were able to take the drug
orally; 600 mg quinine sulphate was then
given orally at eight-hourly intervals for
seven days.
Maternal
mortality
Neonatal
mortality
Perinatal
mortality
Stillbirth
Primary
postpartum
haemorrhage
Maternal
mortality
Appendix 4.1
While intrauterine mortality was
approximately the same in both groups,
neonatal mortality differed significantly
(2.6 vs 19.2%). It is concluded that an
expectant attitude, rather than an
active and induction-oriented one, is
most favourable in cases with preterm
rupture of membranes, also in settings
in which prevalence figures of sexually
transmitted diseases and other genital
infections are high.
No occurrence of postpartum
haemorrhage and no difference in
secondary outcomes. Misoprostol judged
as safe and effective as oxytocin.
The overall maternal mortality rate in
the obstetric department fell from 341
per 100,000 live births to 54 per 100,000
within five years, partly because of the
improved care of pregnant women with
malaria. Whereas in 1981 there were
eight deaths among 379 pregnant
women with the disease, in 1986 there
were no deaths among 299 such cases.
What are the effects of different models of delivery for improving maternal and infant health outcomes for poor people in urban areas in low income
and lower middle income countries?
203