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Full Report - Research for Development - Department for ...

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Author<br />

(year)<br />

(IV)/(EV)<br />

Kuhn (2008)<br />

(++)/(++)<br />

Mbori-<br />

Ngacha<br />

(2001)<br />

(++)/(++)<br />

Nduati<br />

(2001)<br />

(++)/(-)<br />

Target<br />

Population<br />

HIV-infected<br />

women<br />

HIV-infected<br />

infants<br />

HIV-1<br />

infected<br />

women<br />

HIV-1<br />

infected<br />

women<br />

Brief intervention description Targeted<br />

Outcome(s)<br />

Abrupt weaning at 4 months compared with<br />

the standard practice.<br />

Formula feeding of infants of HIV-infected<br />

women compared with breastfeeding.<br />

HIV-free<br />

survival<br />

Infant<br />

mortality<br />

Breastfeeding and <strong>for</strong>mula. Maternal<br />

mortality<br />

Infant<br />

mortality<br />

Findings summary<br />

Appendix 4.4<br />

Early, abrupt cessation of breastfeeding by<br />

HIV-infected women in a low-resource<br />

setting, such as Lusaka, Zambia, did not<br />

improve the rate of HIV-free survival among<br />

children born to HIV-infected mothers and<br />

was harmful to HIV-infected infants.<br />

Similar mortality rates during the first 2<br />

years of life. However, HIV-1-free survival at<br />

2 years was significantly higher in the<br />

<strong>for</strong>mula arm.<br />

Mortality among mothers was higher in the<br />

breastfeeding group than in the <strong>for</strong>mula<br />

group. There was an association between<br />

maternal death and subsequent infant<br />

death.<br />

What are the effects of different models of delivery <strong>for</strong> improving maternal and infant health outcomes <strong>for</strong> poor people in urban areas in low income<br />

and lower middle income countries?<br />

225

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