Organohalogen concentrations and a gross and histologic ...

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106 Third order polynomial regressions (intercept, 1st, 2nd and 3rd order) describing the development over time (1892-2002) in the absolute magnitude of FA (L-R) for subadults, adult males and adult females, separately, showed non-significant influences of the 1st, 2nd and 3rd order variables in nine of the fourteen traits indicating no time trends. The exception from this was trait 22 (adult males), 29 (subadults), 33 (adult females), 37 (subadults) and 38 (adult females). For trait 22 and 33 the intercept, 1st and 2nd order variable were significant (all: p
(oxy-chlordane, trans-chlordane, cis-chlordane), HCB, PBDEs (35 IUPAC congeners) and dieldrin in the recently collected polar bears from the years 1999 through 2002 are viewed in Table 8A. It is seen that sum (Σ) PCBs and dieldrin constitute the highest levels followed by Σ-DDTs, Σ-HCHs and dieldrin while HCB and Σ-PBDEs carry the lowest levels. Further details on these levels in relation to season, sex and age are given in Dietz et al., (2004). Table 8B gives the results from the analysis from the Spearman correlation of individual FA versus contaminant concentrations. All of the correlation coefficients were low and non-significant but for trait 31 this was significant negatively correlated to DDTs and for trait 35 this was significant negatively correlated to PCBs. On the other hand trait 37 was significant positively correlated to Σ-PCBs. However, none of these three correlation results were significant after Bouferroni correction of the p-estimates (Table 8.b). Table 8A Basic statistics of organohalogen compounds (OHCs) analysed in the present study (levels in ng/g l.w.). SD: Standard Deviation; n=count. PCBs and Chlordanes were the predominating groups while DDTs, HCHs and Dieldrin were rather low. HCB and PBDEs were the lowest contaminant concentrations analysed. Variable/statistics Mean ± SD Min-max n ∑−PCBs 6444 ± 3236 897-20407 77 HCB 77 ± 66 2-331 77 ∑−HCHs 194 ± 123 14-818 77 ∑−DDTs 391 ± 215 73-1113 77 Dieldrin 185 ± 81 26-490 77 ∑−CHLs 1395 ± 1016 243-7465 77 ∑−PBDEs 55 ± 32 17-196 78 Table 8B Spearman correlation coefficients between concentrations of individual OHCs and magnitude of FA traits (L-R). Non significant differences are not indicated while ’ * ’: indicates statistic significant differences at the p=0.05 level; ’ ** ’: indicates statistic significant differences at the p=0.01 level and ’ *** ’: indicates statistic significant differences at p=0.001 level. ’ † ’: indicates that the results were no longer significant after Bonferroni correction (k=98). Trait/ Variable 21 22 24 25 28 29 30 31 33 34 35 36 37 38 ∑−PCBs -0.01 0.11 0.18 0.01 -0.003 0.07 -0.1 -0.14 0.08 . HCB 0.13 -0.09 0.13 -0.02 . -0.11 -0.25 *,† -0.07 0.26 *,† 107 0.16 . -0.02 0.2 -0.004 -0.01 0.06 -0.16 -0.002 0.13 0.17 0.03 ∑−HCHs 0.07 -0.07 0.12 -0.07 -0.02 0.15 -0.05 -0.14 -0.01 -0.01 -0.04 0.02 0.11 0.08 ∑−DDTs 0.07 -0.01 0.06 0.02 0.09 0.06 0.12 -0.35 ***,† Dieldrin 0.05 . -0.01 -0.11 -0.08 -0.01 0.03 -0.03 . -0.11 0.04 -0.01 -0.07 -0.02 0.01 -0.16 0.02 0.02 -0.2 0.1 0.16 0.01 ∑−CHLs 0.04 -0.13 0.05 -0,14 -0.002 -0.14 -0.11 -0.08 0.05 0.004 -0.2 -0.02 0.18 -0.02 ∑−PBDEs 0.13 -0.12 -0.04 0.18 -0.03 -0.12 -0.1 -0.05 0.04 0.13 -0.03 -0.07 -0.08 0.02
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National Environmental Research Ins
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National Environmental Research Ins
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Contents Summary 7 Resumé 11 Prefa
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Paper III-b Periodontitis and tooth
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Summary Marine mammals in the Arcti
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elations between histological chang
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Resumé Betydelige mængder svært
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signifikante relationer blev fundet
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Preface Since ca. 1960 signficant a
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Acquarone, Poul Johansen and Inge B
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Abbreviations ∑ Sum of congeners
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Introduction Study area and samplin
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content and composition) varying wi
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Of the PCBs found in the East Green
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son Bay bears while the difference
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Individual levels and biological ef
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No. skulls collected 50 45 40 35 30
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temperature extremes and/or food av
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Chapter 3 Bone mineral density and
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BMD analysed by DXA reflects the ar
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Table 4 Range in the levels (ng/g l
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Chapter 4 Liver histology of East G
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Table 7 Levels of ∑-PCBs, ∑-DDT
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Frequency (%) 100 80 60 40 20 Sever
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Effects of PBBs (PolyBrominated Bip
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Etiology and pathogenesis E Figure
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common sign (Acland 1995, Feldman 1
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Conclusions and final assessments O
Page 57 and 58: of CYP-450 activity that impact cir
Page 59 and 60: Regarding renal tissue, we will try
Page 61 and 62: Bernhoft, A., Ø. Wiig and J. U. Sk
Page 63 and 64: Feldman, E. C. (1995): Hyperadrenoc
Page 65 and 66: (eds.): Ringed seals in the North A
Page 67 and 68: McCormack, K. M., W. M. Kluwe, V. L
Page 69 and 70: Rosing-Asvid, A., E. W. Born and M.
Page 71 and 72: Valentino, R., S. Savastano, A. P.
Page 73 and 74: Paper I Seasonal and temporal trend
Page 75 and 76: eproductive rates of seals in the B
Page 77 and 78: concentrations of the 41 individual
Page 79 and 80: Figure 1 Capture locations of the p
Page 81 and 82: Table 4 Results of ANOVAs (F-value
Page 83 and 84: Long-Term Temporal Changes in OC Co
Page 85 and 86: Discussion Geographical Variation i
Page 87 and 88: sen et al. (2001) studied the trend
Page 89 and 90: higher than reported in other studi
Page 91 and 92: Bergman A, Olsson M. Pathology of b
Page 93 and 94: Muir D, Norstrom RJ. Geographical d
Page 95 and 96: Wiig Ø, Gjertz I, Hansson R, Thoma
Page 97 and 98: Key words: polar bear, Ursus mariti
Page 99 and 100: 2. Materials and methods 2.1 Sampli
Page 101 and 102: 2.3 Age Determination The age deter
Page 103 and 104: No. skulls collected 50 45 40 35 30
Page 105 and 106: Table 4 Results (test and p-values)
Page 107: Table 6 Results from F-tests (p-val
Page 111 and 112: Also Pertoldi et al. (1997) investi
Page 113 and 114: study could not document a relation
Page 115 and 116: Lie E, Bernhoft A, Riget FF, Beliko
Page 117 and 118: function in harbour seals (Phoca vi
Page 119 and 120: (p=0.94). Negative correlation betw
Page 121 and 122: Osteodensitometry X-ray osteodensit
Page 123 and 124: Figure 2 BMD (g cm 2 ) in skulls fr
Page 125 and 126: Table 3 Significant results from th
Page 127 and 128: 2003) and plasma retinol and thyroi
Page 129 and 130: Comiso JC. 2002. A rapidly declinin
Page 131 and 132: Manalagas SC, Jilka RJ. 1995. Bone
Page 133 and 134: Valentine DW, Soulé M. 1973. Effec
Page 135 and 136: have the potential for adverse heal
Page 137 and 138: Dioxin-like contaminants Extraction
Page 139 and 140: Concentration 9000 8000 7000 6000 5
Page 141 and 142: Acknowledgements Danish Cooperation
Page 143 and 144: Polischuk, S. C., R. J. Letcher, R.
Page 145 and 146: Paper IV Liver histology of free-ra
Page 147 and 148: Histology All tissue samples were t
Page 149 and 150: Figure 1 Hepatic lipid accumulation
Page 151 and 152: Figure 2 Left: Portal mononuclear c
Page 153 and 154: Relationship between histology and
Page 155 and 156: kinson 1996). Due to these mechanis
Page 157 and 158: sues. Arctic Monitoring and Assessm
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van Duursen, M.B.M., Sanderson, J.
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Introduction Polar bears (Ursus mar
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Briefly, ∑PCBs is the sum (s) of
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Figure 1 Bottom: example of glomeru
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Figure 3 Tubular cell proliferation
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Hyalin casts Hyalin casts were eval
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Figure 6 Hyperemia (arrows) in the
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al., 2003). We did not find such a
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ANDERSEN, M., E. LIE, A. E. DEROCHE
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LUROSS, J. M., M. ALAEE, D. B. SERG
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organic mercury in liver and kidney
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Introduction Polar bears (Ursus mar
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Macroscopic examination of reproduc
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Results and discussion The female p
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SC II PC/LC Figure 2 The histology
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The relatively low levels of analys
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(Table 4), and we therefore conclud
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Acknowledgements Danish Cooperation
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Letcher RJ, Klasson-Wehler E, Bergm
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Swart RL, Ross PS, Vedder LJ, Timme
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10. Heier, A., C. Sonne, A. Gröne,
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crine organs and skulls in the East
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To investigate the relation between
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