Organohalogen concentrations and a gross and histologic ...

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130 In: Marine Environment (chapter 4) (Riget, F. F., J. Christensen and P. Johansen, eds). Copenhagen, PA: Ministry of Environment, Denmark. Rosing-Asvid A, Born EW, Kingsley MCS. 2002. Age at sexual maturity of males and timing of the mating season of polar bears (Ursus maritimus) in Greenland. Polar Biol 25:878-883. Rothcock DA, Yu Y, Maykut GA. 1999. Thinning of the Arctic sea-ice cover. Geophys Res Lett 26(23):3469-3472. Sandala GM, Sonne-Hansen C, Dietz R, Muir DCG, Valters K, Bennett ER, Letcher RJ. 2004. Methyl sulfone and hydroxylated PCB metabolites in adipose and whole blood of polar bear (Ursus maritimus) from Scoresby Sound, Greenland. Sci Total Environ 2004 331:125-141. Sarazin M, Alexandre C, Thomas T. 2000. Influenze on bone metabolism of dietary trace elements, protein, fat, carbohydrates and vitamins. Joint Bone Spine 67(5):408-418. Schandorff S. 1997a. Developmental stability and skull lesions in the harbour seal (Phoca vitulina) in the 19 th and 20 th centuries. Ann Zool fennici 34:151-166. Schandorff S. 1997b. Developmental stability and the harbour seal epizootic in 1998. Ann Zool fennici 34:167-175. Selye H. 1973. The evolution of the stress concept. Am Sci 61:692-699. Siegel MI, Doyle WJ. 1975a. The differential effects of prenatal and postnatal audiogenic stress on fluctuating dental asymmetry. J Exp Zool 191:211-214. Siegel MI, Doyle WJ. 1975b. Stress and fluctuating limb asymmetry in various species of rodents. Growth 39:363-369. Siegel P, Siegel MI, Krimmer EC, Doyle WJ, Barry H. 1977. Fluctuating dental asymmmetry as an indicator of the stressful prenatal effects of 9 - tetrahydrocannabinol in the laboratory rat. Toxicol App Pharmacol 42:339- 344. Siegel MI, Mooney MP. 1987. Perinatal stress and increased fluctuating asymmetry of dental calcium in the laboratory rat. Am J Phys Anthropol 73:267-270. Siegel MI, Mooney MP, Taylor AB. 1992. Dental and skeletal reduction as a consequence of environmental stress. Acta Zool Fennica 191:145-149. Singh S, Casper RF, Fritz PC, Sukhu B, Ganss B, Girard B, Savouret JF, Tenenbaum HC. 2000. Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol. J Endocrinol 167(1):183-195. Skaare JU, Bernhoft A, Wiig Ø, Norum KR, Haug E, Eide DM, Derocher AE. 2001. Relationship between plasma levels of organochlorines, retinol and thyroid hormones from polar bears (Ursus maritimus) at Svalbard. J Toxicol Environ Health A 62:227-241. Sonne-Hansen, C, Dietz R, Leifsson PS, Hyldstrup L, Riget FF. 2002. Cadmium toxicity to ringed seals (Phoca hispida) - An epidemiological study of possible cadmium induced nephropathy and osteodystrophy in ringed seals (Phoca hispida) from Qaanaaq in Northwest Greenland. Sci Total Environ 295 (I-III):167-181. Stirling I Lunn NJ, Iacozza J. 1999. Long-term trends in the population ecology of polar bears in western Hudson Bay in relation to climatic change. Arctic 52 (3):294-306. Szulc P, Hofbauer LC, Heufelder AE, Roth S, Delmas PDF. 2001. Osteoprotegerin serum levels in men: correlation with age, esrogen and testosterone status. J Clin Endocr Metab 86(7):3162-3165.
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National Environmental Research Ins
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National Environmental Research Ins
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Contents Summary 7 Resumé 11 Prefa
Page 7 and 8:
Paper III-b Periodontitis and tooth
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Summary Marine mammals in the Arcti
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elations between histological chang
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Resumé Betydelige mængder svært
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signifikante relationer blev fundet
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Preface Since ca. 1960 signficant a
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Acquarone, Poul Johansen and Inge B
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Abbreviations ∑ Sum of congeners
Page 23 and 24:
Introduction Study area and samplin
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content and composition) varying wi
Page 27 and 28:
Of the PCBs found in the East Green
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son Bay bears while the difference
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Individual levels and biological ef
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No. skulls collected 50 45 40 35 30
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temperature extremes and/or food av
Page 37 and 38:
Chapter 3 Bone mineral density and
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BMD analysed by DXA reflects the ar
Page 41 and 42:
Table 4 Range in the levels (ng/g l
Page 43 and 44:
Chapter 4 Liver histology of East G
Page 45 and 46:
Table 7 Levels of ∑-PCBs, ∑-DDT
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Frequency (%) 100 80 60 40 20 Sever
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Effects of PBBs (PolyBrominated Bip
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Etiology and pathogenesis E Figure
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common sign (Acland 1995, Feldman 1
Page 55 and 56:
Conclusions and final assessments O
Page 57 and 58:
of CYP-450 activity that impact cir
Page 59 and 60:
Regarding renal tissue, we will try
Page 61 and 62:
Bernhoft, A., Ø. Wiig and J. U. Sk
Page 63 and 64:
Feldman, E. C. (1995): Hyperadrenoc
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(eds.): Ringed seals in the North A
Page 67 and 68:
McCormack, K. M., W. M. Kluwe, V. L
Page 69 and 70:
Rosing-Asvid, A., E. W. Born and M.
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Valentino, R., S. Savastano, A. P.
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Paper I Seasonal and temporal trend
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eproductive rates of seals in the B
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concentrations of the 41 individual
Page 79 and 80:
Figure 1 Capture locations of the p
Page 81 and 82: Table 4 Results of ANOVAs (F-value
Page 83 and 84: Long-Term Temporal Changes in OC Co
Page 85 and 86: Discussion Geographical Variation i
Page 87 and 88: sen et al. (2001) studied the trend
Page 89 and 90: higher than reported in other studi
Page 91 and 92: Bergman A, Olsson M. Pathology of b
Page 93 and 94: Muir D, Norstrom RJ. Geographical d
Page 95 and 96: Wiig Ø, Gjertz I, Hansson R, Thoma
Page 97 and 98: Key words: polar bear, Ursus mariti
Page 99 and 100: 2. Materials and methods 2.1 Sampli
Page 101 and 102: 2.3 Age Determination The age deter
Page 103 and 104: No. skulls collected 50 45 40 35 30
Page 105 and 106: Table 4 Results (test and p-values)
Page 107 and 108: Table 6 Results from F-tests (p-val
Page 109 and 110: (oxy-chlordane, trans-chlordane, ci
Page 111 and 112: Also Pertoldi et al. (1997) investi
Page 113 and 114: study could not document a relation
Page 115 and 116: Lie E, Bernhoft A, Riget FF, Beliko
Page 117 and 118: function in harbour seals (Phoca vi
Page 119 and 120: (p=0.94). Negative correlation betw
Page 121 and 122: Osteodensitometry X-ray osteodensit
Page 123 and 124: Figure 2 BMD (g cm 2 ) in skulls fr
Page 125 and 126: Table 3 Significant results from th
Page 127 and 128: 2003) and plasma retinol and thyroi
Page 129 and 130: Comiso JC. 2002. A rapidly declinin
Page 131: Manalagas SC, Jilka RJ. 1995. Bone
Page 135 and 136: have the potential for adverse heal
Page 137 and 138: Dioxin-like contaminants Extraction
Page 139 and 140: Concentration 9000 8000 7000 6000 5
Page 141 and 142: Acknowledgements Danish Cooperation
Page 143 and 144: Polischuk, S. C., R. J. Letcher, R.
Page 145 and 146: Paper IV Liver histology of free-ra
Page 147 and 148: Histology All tissue samples were t
Page 149 and 150: Figure 1 Hepatic lipid accumulation
Page 151 and 152: Figure 2 Left: Portal mononuclear c
Page 153 and 154: Relationship between histology and
Page 155 and 156: kinson 1996). Due to these mechanis
Page 157 and 158: sues. Arctic Monitoring and Assessm
Page 159 and 160: van Duursen, M.B.M., Sanderson, J.
Page 161 and 162: Introduction Polar bears (Ursus mar
Page 163 and 164: Briefly, ∑PCBs is the sum (s) of
Page 165 and 166: Figure 1 Bottom: example of glomeru
Page 167 and 168: Figure 3 Tubular cell proliferation
Page 169 and 170: Hyalin casts Hyalin casts were eval
Page 171 and 172: Figure 6 Hyperemia (arrows) in the
Page 173 and 174: al., 2003). We did not find such a
Page 175 and 176: ANDERSEN, M., E. LIE, A. E. DEROCHE
Page 177 and 178: LUROSS, J. M., M. ALAEE, D. B. SERG
Page 179 and 180: organic mercury in liver and kidney
Page 181 and 182: Introduction Polar bears (Ursus mar
Page 183 and 184:
Macroscopic examination of reproduc
Page 185 and 186:
Results and discussion The female p
Page 187 and 188:
SC II PC/LC Figure 2 The histology
Page 189 and 190:
The relatively low levels of analys
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(Table 4), and we therefore conclud
Page 193 and 194:
Acknowledgements Danish Cooperation
Page 195 and 196:
Letcher RJ, Klasson-Wehler E, Bergm
Page 197 and 198:
Swart RL, Ross PS, Vedder LJ, Timme
Page 199 and 200:
10. Heier, A., C. Sonne, A. Gröne,
Page 201 and 202:
crine organs and skulls in the East
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To investigate the relation between
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