Organohalogen concentrations and a gross and histologic ...

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176 ROSING-ASVID, A., E. W. BORN, AND M. C. S. KINGSLEY. 2002. Age at sexual maturity of males and timing of the mating season of polar bears (Ursus maritimus) in Greenland. Polar Biol 25: 878-883. ROSS, P. S., R. L. DE SWART, P. J. H. REIJNDERS, H. VAN LOVEREN, J. G. V. VOS, AND A. D. M. E. OSTERHAUS. 1995. Contaminant related suppression of delayed-type hypersensitivity and antibody respons in harbour seals fed herring from the Baltic Sea. Environ Hlth Persp 103: 162-167. _______, _______, H. H. TIMMERMANN, P. J. H. REIJNDERS, _______, H. VAN LOVEREN, AND A. D. M. E. OSTERHAUS. 1996. Suppression of natural killer cell activity in harbour seals (Phoca vitulina) fed Baltic Sea herring. Aquat Toxicol 34: 71-84. SANDALA, G.M., C. SONNE-HANSEN, R. DIETZ, R., D. C. G. MUIR, K. VALTERS, E. R. BENNETT, AND R. J. LETCHER. 2004. Methyl sulfone and hydroxylated PCB metabolites in adipose and whole blood of polar bear (Ursus maritimus) from Scoresby Sound, Greenland. Sci Total Environ 331: 125-141. SATO, M., M. MIURA, N. KOJIMA, N. HIGASHI, K. IMAI, T. SATO, H. L. WOLD, J. Ø. MOSKAUG, R. BLOMHOFF, K. WAKE, N. ROOS, T. BERG, T. R. NORUM, AND H. SENOO. 2001. Nuclear deviation in hepatic parenchymal cells on sinusoidal surfaces in arctic animals. Cell struct and funct 26: 71-77. SKAARE, J. U., A. BERNHOFT, Ø. WIIG, K. R. NORUM, E. HAUG, D. M. EIDE, AND A. E. DEROCHER. 2001. Relationship between plasma levels of organochlorines, retinol and thyroid hormones from polar bears (Ursus maritimus) at Svalbard. J Toxicol Environ Health A 62: 227-241. SONNE, C., R. DIETZ, E. W. BORN, F. F. RIGET, M. KIRKEGAARD, L. HYLDSTRUP, R. J. LETCHER, AND D. C. G. MUIR. ACCEPTED WITH REVISION. Is bone mineral composition disrupted by organochlorines in East Greenland polar bears (Ursus maritimus)? Environ Hlth Persp. _______, _______, P. S. LEIFSSON, E. W. BORN, _______, F. F. RIGET, _______, _______, AND L. HYLDSTRUP. SUBMITTED. Liver histology of free-ranging polar bears (Ursus maritimus) from East Greenland. Toxicol Pathol. SONNE-HANSEN, C., _______, _______, L. HYLDSTRUP, AND F. F. RIGET. 2002. Cadmium toxicity to ringed seals (Phoca hispida) - An epidemiological study of possible cadmium induced nephropathy and osteodystrophy in ringed seals (Phoca hispida) from Qaanaaq in Northwest Greenland. Sci Total Environ 295 (I-III): 167-181. SWART, R. L., P. S. ROSS, L. J. VEDDER, H. H. TIMMERMAN, S. HEIS- TERKAMP, H. V. LOVEREN, J. G. VOS, P. J. H. REIJNDERS, AND A. D. M. E. OSTERHAUS. 1994. Impairment of immune function in harbour seals (Phoca vitulina) feeding on fish from polluted waters. Ambio 23: 155-159. TREVAN, D. 1956. Glomerular changes induced by stilboestrol. Lancet 2: 22- 23. WADE, M. G., W. G. FOSTER, E. W. YOUNGLAI, A. MCMAHON, K. LEINGARTNER, A. YAGMINAS, D. BLAKEY, M. FOURNIER, D. DE- SAULNIERS, AND C. L. HUGHES. 2002. Effects of subchronic exposure to a complex mixture of persistent contaminants in male rats: Systemic, immune, and reproductive effects. Toxicol Sci 67 (1), 131-143. WHO. 1992. IPCS, Environmental Health Criteria 134: Cadmium. WHO, Geneva, Schweiz: pp. 1-209. WOSHNER, V. M., T. M. O’HARA, J. A. EURELL, M. A. WALLIG, G. R. BRATTON, R. S. SUYDAM, AND V. R. BEASLEY. 2002. Distribution of in-
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National Environmental Research Ins
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National Environmental Research Ins
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Contents Summary 7 Resumé 11 Prefa
Page 7 and 8:
Paper III-b Periodontitis and tooth
Page 9 and 10:
Summary Marine mammals in the Arcti
Page 11 and 12:
elations between histological chang
Page 13 and 14:
Resumé Betydelige mængder svært
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signifikante relationer blev fundet
Page 17 and 18:
Preface Since ca. 1960 signficant a
Page 19 and 20:
Acquarone, Poul Johansen and Inge B
Page 21 and 22:
Abbreviations ∑ Sum of congeners
Page 23 and 24:
Introduction Study area and samplin
Page 25 and 26:
content and composition) varying wi
Page 27 and 28:
Of the PCBs found in the East Green
Page 29 and 30:
son Bay bears while the difference
Page 31 and 32:
Individual levels and biological ef
Page 33 and 34:
No. skulls collected 50 45 40 35 30
Page 35 and 36:
temperature extremes and/or food av
Page 37 and 38:
Chapter 3 Bone mineral density and
Page 39 and 40:
BMD analysed by DXA reflects the ar
Page 41 and 42:
Table 4 Range in the levels (ng/g l
Page 43 and 44:
Chapter 4 Liver histology of East G
Page 45 and 46:
Table 7 Levels of ∑-PCBs, ∑-DDT
Page 47 and 48:
Frequency (%) 100 80 60 40 20 Sever
Page 49 and 50:
Effects of PBBs (PolyBrominated Bip
Page 51 and 52:
Etiology and pathogenesis E Figure
Page 53 and 54:
common sign (Acland 1995, Feldman 1
Page 55 and 56:
Conclusions and final assessments O
Page 57 and 58:
of CYP-450 activity that impact cir
Page 59 and 60:
Regarding renal tissue, we will try
Page 61 and 62:
Bernhoft, A., Ø. Wiig and J. U. Sk
Page 63 and 64:
Feldman, E. C. (1995): Hyperadrenoc
Page 65 and 66:
(eds.): Ringed seals in the North A
Page 67 and 68:
McCormack, K. M., W. M. Kluwe, V. L
Page 69 and 70:
Rosing-Asvid, A., E. W. Born and M.
Page 71 and 72:
Valentino, R., S. Savastano, A. P.
Page 73 and 74:
Paper I Seasonal and temporal trend
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eproductive rates of seals in the B
Page 77 and 78:
concentrations of the 41 individual
Page 79 and 80:
Figure 1 Capture locations of the p
Page 81 and 82:
Table 4 Results of ANOVAs (F-value
Page 83 and 84:
Long-Term Temporal Changes in OC Co
Page 85 and 86:
Discussion Geographical Variation i
Page 87 and 88:
sen et al. (2001) studied the trend
Page 89 and 90:
higher than reported in other studi
Page 91 and 92:
Bergman A, Olsson M. Pathology of b
Page 93 and 94:
Muir D, Norstrom RJ. Geographical d
Page 95 and 96:
Wiig Ø, Gjertz I, Hansson R, Thoma
Page 97 and 98:
Key words: polar bear, Ursus mariti
Page 99 and 100:
2. Materials and methods 2.1 Sampli
Page 101 and 102:
2.3 Age Determination The age deter
Page 103 and 104:
No. skulls collected 50 45 40 35 30
Page 105 and 106:
Table 4 Results (test and p-values)
Page 107 and 108:
Table 6 Results from F-tests (p-val
Page 109 and 110:
(oxy-chlordane, trans-chlordane, ci
Page 111 and 112:
Also Pertoldi et al. (1997) investi
Page 113 and 114:
study could not document a relation
Page 115 and 116:
Lie E, Bernhoft A, Riget FF, Beliko
Page 117 and 118:
function in harbour seals (Phoca vi
Page 119 and 120:
(p=0.94). Negative correlation betw
Page 121 and 122:
Osteodensitometry X-ray osteodensit
Page 123 and 124:
Figure 2 BMD (g cm 2 ) in skulls fr
Page 125 and 126:
Table 3 Significant results from th
Page 127 and 128: 2003) and plasma retinol and thyroi
Page 129 and 130: Comiso JC. 2002. A rapidly declinin
Page 131 and 132: Manalagas SC, Jilka RJ. 1995. Bone
Page 133 and 134: Valentine DW, Soulé M. 1973. Effec
Page 135 and 136: have the potential for adverse heal
Page 137 and 138: Dioxin-like contaminants Extraction
Page 139 and 140: Concentration 9000 8000 7000 6000 5
Page 141 and 142: Acknowledgements Danish Cooperation
Page 143 and 144: Polischuk, S. C., R. J. Letcher, R.
Page 145 and 146: Paper IV Liver histology of free-ra
Page 147 and 148: Histology All tissue samples were t
Page 149 and 150: Figure 1 Hepatic lipid accumulation
Page 151 and 152: Figure 2 Left: Portal mononuclear c
Page 153 and 154: Relationship between histology and
Page 155 and 156: kinson 1996). Due to these mechanis
Page 157 and 158: sues. Arctic Monitoring and Assessm
Page 159 and 160: van Duursen, M.B.M., Sanderson, J.
Page 161 and 162: Introduction Polar bears (Ursus mar
Page 163 and 164: Briefly, ∑PCBs is the sum (s) of
Page 165 and 166: Figure 1 Bottom: example of glomeru
Page 167 and 168: Figure 3 Tubular cell proliferation
Page 169 and 170: Hyalin casts Hyalin casts were eval
Page 171 and 172: Figure 6 Hyperemia (arrows) in the
Page 173 and 174: al., 2003). We did not find such a
Page 175 and 176: ANDERSEN, M., E. LIE, A. E. DEROCHE
Page 177: LUROSS, J. M., M. ALAEE, D. B. SERG
Page 181 and 182: Introduction Polar bears (Ursus mar
Page 183 and 184: Macroscopic examination of reproduc
Page 185 and 186: Results and discussion The female p
Page 187 and 188: SC II PC/LC Figure 2 The histology
Page 189 and 190: The relatively low levels of analys
Page 191 and 192: (Table 4), and we therefore conclud
Page 193 and 194: Acknowledgements Danish Cooperation
Page 195 and 196: Letcher RJ, Klasson-Wehler E, Bergm
Page 197 and 198: Swart RL, Ross PS, Vedder LJ, Timme
Page 199 and 200: 10. Heier, A., C. Sonne, A. Gröne,
Page 201 and 202: crine organs and skulls in the East
Page 203: To investigate the relation between
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