Organohalogen concentrations and a gross and histologic ...

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(ng g lw -1) (ng g lw -1) (ng g lw -1) 80 12000 10000 8000 6000 4000 2000 0 400 350 300 250 200 150 100 50 0 200 150 100 50 0 PCBs 900 800 DDTs 700 600 500 400 300 200 100 0 HCHs CHLs 3000 CBz 2500 2000 1500 1000 500 0 Jan Feb Mar Apr-Jul Aug Sep Oct Jan Feb Mar Apr-Jul Aug Sep Oct Adult F Adult M Sub adult 0 300 250 200 150 100 50 Dieldrin Figure 2 Seasonal averages of ∑-PCB, ∑-DDT, ∑-HCH, ∑-CHL, ∑-CBz and Dieldrin (ng/g lw) presented for subadult, adult males and adult females. Table 5 Probability of significance derived from ANOVAs with logarithmic transformed concentrations of OC in polar bears from Scoresby Sound (1999-2001) as dependent variable and the factors: organoclorine compound (C), month (M), sex and age group (G) and their first order interactions. Compound Month Age/sex group Interaction C-M Interaction C-G Interaction M-G All compounds
Long-Term Temporal Changes in OC Concentrations The following OCs were determined in polar bear fat in both the Norstrom et al. (1998) and the present study: CB congener numbers 99, 149, 118, 146, 153, 138, 183, 180, 170/190 and 194, α- and β-HCH, p,p’-DDE, p,p’-DDD and p,p’-DDT, oxychlordane, trans-nonachlor and heptachlor epoxide, and dieldrin. An ANOVA was performed on selected compound classes, congeners and metabolites with the factors sex and age group, sampling period and their interactions (Table 6). For all OCs, the difference in concentrations between the two periods was highly significant with a significance level of p
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National Environmental Research Ins
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National Environmental Research Ins
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Contents Summary 7 Resumé 11 Prefa
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Paper III-b Periodontitis and tooth
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Summary Marine mammals in the Arcti
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elations between histological chang
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Resumé Betydelige mængder svært
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signifikante relationer blev fundet
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Preface Since ca. 1960 signficant a
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Acquarone, Poul Johansen and Inge B
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Abbreviations ∑ Sum of congeners
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Introduction Study area and samplin
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content and composition) varying wi
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Of the PCBs found in the East Green
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son Bay bears while the difference
Page 31 and 32: Individual levels and biological ef
Page 33 and 34: No. skulls collected 50 45 40 35 30
Page 35 and 36: temperature extremes and/or food av
Page 37 and 38: Chapter 3 Bone mineral density and
Page 39 and 40: BMD analysed by DXA reflects the ar
Page 41 and 42: Table 4 Range in the levels (ng/g l
Page 43 and 44: Chapter 4 Liver histology of East G
Page 45 and 46: Table 7 Levels of ∑-PCBs, ∑-DDT
Page 47 and 48: Frequency (%) 100 80 60 40 20 Sever
Page 49 and 50: Effects of PBBs (PolyBrominated Bip
Page 51 and 52: Etiology and pathogenesis E Figure
Page 53 and 54: common sign (Acland 1995, Feldman 1
Page 55 and 56: Conclusions and final assessments O
Page 57 and 58: of CYP-450 activity that impact cir
Page 59 and 60: Regarding renal tissue, we will try
Page 61 and 62: Bernhoft, A., Ø. Wiig and J. U. Sk
Page 63 and 64: Feldman, E. C. (1995): Hyperadrenoc
Page 65 and 66: (eds.): Ringed seals in the North A
Page 67 and 68: McCormack, K. M., W. M. Kluwe, V. L
Page 69 and 70: Rosing-Asvid, A., E. W. Born and M.
Page 71 and 72: Valentino, R., S. Savastano, A. P.
Page 73 and 74: Paper I Seasonal and temporal trend
Page 75 and 76: eproductive rates of seals in the B
Page 77 and 78: concentrations of the 41 individual
Page 79 and 80: Figure 1 Capture locations of the p
Page 81: Table 4 Results of ANOVAs (F-value
Page 85 and 86: Discussion Geographical Variation i
Page 87 and 88: sen et al. (2001) studied the trend
Page 89 and 90: higher than reported in other studi
Page 91 and 92: Bergman A, Olsson M. Pathology of b
Page 93 and 94: Muir D, Norstrom RJ. Geographical d
Page 95 and 96: Wiig Ø, Gjertz I, Hansson R, Thoma
Page 97 and 98: Key words: polar bear, Ursus mariti
Page 99 and 100: 2. Materials and methods 2.1 Sampli
Page 101 and 102: 2.3 Age Determination The age deter
Page 103 and 104: No. skulls collected 50 45 40 35 30
Page 105 and 106: Table 4 Results (test and p-values)
Page 107 and 108: Table 6 Results from F-tests (p-val
Page 109 and 110: (oxy-chlordane, trans-chlordane, ci
Page 111 and 112: Also Pertoldi et al. (1997) investi
Page 113 and 114: study could not document a relation
Page 115 and 116: Lie E, Bernhoft A, Riget FF, Beliko
Page 117 and 118: function in harbour seals (Phoca vi
Page 119 and 120: (p=0.94). Negative correlation betw
Page 121 and 122: Osteodensitometry X-ray osteodensit
Page 123 and 124: Figure 2 BMD (g cm 2 ) in skulls fr
Page 125 and 126: Table 3 Significant results from th
Page 127 and 128: 2003) and plasma retinol and thyroi
Page 129 and 130: Comiso JC. 2002. A rapidly declinin
Page 131 and 132: Manalagas SC, Jilka RJ. 1995. Bone
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Valentine DW, Soulé M. 1973. Effec
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have the potential for adverse heal
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Dioxin-like contaminants Extraction
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Concentration 9000 8000 7000 6000 5
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Acknowledgements Danish Cooperation
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Polischuk, S. C., R. J. Letcher, R.
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Paper IV Liver histology of free-ra
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Histology All tissue samples were t
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Figure 1 Hepatic lipid accumulation
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Figure 2 Left: Portal mononuclear c
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Relationship between histology and
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kinson 1996). Due to these mechanis
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sues. Arctic Monitoring and Assessm
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van Duursen, M.B.M., Sanderson, J.
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Introduction Polar bears (Ursus mar
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Briefly, ∑PCBs is the sum (s) of
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Figure 1 Bottom: example of glomeru
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Figure 3 Tubular cell proliferation
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Hyalin casts Hyalin casts were eval
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Figure 6 Hyperemia (arrows) in the
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al., 2003). We did not find such a
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ANDERSEN, M., E. LIE, A. E. DEROCHE
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LUROSS, J. M., M. ALAEE, D. B. SERG
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organic mercury in liver and kidney
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Introduction Polar bears (Ursus mar
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Macroscopic examination of reproduc
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Results and discussion The female p
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SC II PC/LC Figure 2 The histology
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The relatively low levels of analys
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(Table 4), and we therefore conclud
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Acknowledgements Danish Cooperation
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Letcher RJ, Klasson-Wehler E, Bergm
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Swart RL, Ross PS, Vedder LJ, Timme
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10. Heier, A., C. Sonne, A. Gröne,
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crine organs and skulls in the East
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To investigate the relation between
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