Organohalogen concentrations and a gross and histologic ...

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196 Appendix Entire publication list for Christian Sonne. Publications marked ”included” indicate that they are used in the present Ph.D. thesis. Published papers and manuscripts 2002-2004 1. Sonne-Hansen C., R. Dietz, P. S. Leifsson, L. Hyldstrup and F. F. Riget (2002): Cadmium toxicity to ringed seals (Phoca hispida) - An epidemiological study of possible cadmium induced nephropathy and osteodystrophy in ringed seals (Phoca hispida) from Qaanaaq in Northwest Greenland. Sci Total Environ 295 (I-III): 167-181. 2. Sonne C., F. F. Riget, R. Dietz, M. Kirkegaard, E. W. Born, R. J. Letcher and D. C. G. Muir (Submitted): Trends in fluctuating asymmetry in East Greenland polar bears (Ursus maritimus) from 1892 to 2002 in relation to organohalogen pollution. Sci Total Environ. ”Included”. 3. Sonne, C., R. Dietz, F. F. Riget, E. W. Born, M. Kirkegaard, L. Hyldstrup, R. J. Letcher and D. C. G. Muir (Accepted with revision): Is bone mineral composition disrupted by organochlorines in East Greenland polar bears (Ursus maritimus)?. Environ Hlth Persp. ”Included”. 4. Sonne, C., R. Dietz, E. W. Born, M. Kirkegaard, F. F. Riget, R. J. Letcher and D. C. G. Muir (In prep.): Periodontitis and tooth wear in East Greenland polar bears (Ursus maritimus) during 1892-2002. ”Included” 5. Sonne C., R. Dietz, P. S. Leifsson, E. W. Born, M. Kirkegaard, F. F. Riget, R. J. Letcher, D. C. G. Muir and L. Hyldstrup (Submitted): Liver histology of free-ranging East Greenland polar bears (Ursus maritimus) in relation to organohalogen exposure. Toxicol Pathol. ”Included”. 6. Sonne C., R. Dietz, P. S. Leifsson, F. F. Riget, E. W. Born, M. Kirkegaard, R. J. Letcher, D. C. G. Muir and L. Hyldstrup (Submitted): Renal lesions in East Greenland polar bears (Ursus maritimus) during 1999-2002. J Wildlife Dis. ”Included”. 7. Sonne, C., P. S. Leifsson, R. Dietz, E. W. Born, R. J. Letcher, M. Kirkegaard, D. C. G. Muir, L. W. Andersen, F. F. Riget and L. Hyldstrup (In Press): Enlarged clitoris in wild polar bears (Ursus maritimus) can be misdiagnosed as pseudohermaphroditism. Sci Total Environ. ”Included”. 8. Dietz, R., F. F. Riget, C. Sonne, R. J. Letcher , E. W. Born and D. C. G. Muir (2004): Seasonal and temporal trends in Polychlorinated biphenyls and Organochlorine Pesticides in East Greenland polar bears (Ursus maritimus), 1990-2001. Sci Total Environ 331: 107-124. ”Included”. 9. Sandala, G. M., C. Sonne, R. Dietz, D. C. G. Muir, K. Valters, E. R. Bennett, E. W. Born and R. J. Letcher (2004): Hydroxylated and Methyl Sulfone PCB Metabolites in Adipose and Whole Blood of Polar Bear (Ursus maritimus) From East Greenland. Sci Total Environ 331: 125-141.
10. Heier, A., C. Sonne, A. Gröne, P. S. Leifsson, R. Dietz, E. W. Born and L. N. Bacciarini (Submitted): Liver RBP immunohistochemistry in freeranging polar bears. An immunohistochemical study of retinol-binding protein (RBP) in livers of polar bears (Ursus maritimus) from East Greenland. Zoo and Wild Med. 11. Kirkegaard, M, C. Sonne, P.S. Leifsson, R. Dietz, E.W. Born, R. J. Letcher and D.C.G. Muir (Submitted): Histology of selected immunological organs in polar bear (Ursus maritimus) from East Greenland in relation to levels of organohalogenes. Sci Total Environ. 12. Kirkegaard, M., R. Dietz, C. Sonne and E. W. Born (In prep.): Age determination and use of dental structures to determine the reproductive history of female polar bears (Ursus maritimus). 13. Smithwick, M. S., A. de Silva, D. C. G. Muir, S. Mabury, K. Solomon, C. Sonne, R. Dietz and E. W. Born (In prep.): Perfluorinated acids in heptatic tissue from East Greenland polar bears (Ursus maritimus) 1999-2001. 14. Bossi, R., K. Vorkamp, F. F. Riget, R. Dietz, C. Sonne and P. Fauser (Submitted): Perfluorinated surfactants in fish, mammals and birds from Greenland and Faroe Islands. Results from a preliminary screening. Environ Pollut. 15. Muir, D. C. G., R. Dietz, F. F. Riget, C. Sonne, R. J. Letcher and E. W. Born (In prep.): Polybrominated diphenylethers in East Greenland polar bears (Ursus maritimus) 1990-2001. 16. Verreault, J., D. C. G. Muir, R. J. Norstrom, I. Stirling, A. T. Fisk, G. W. Gabrielsen, A. E. Derocher, T. Evans, R. Dietz, C. Sonne, G. M. Sandala, M. K. Taylor, J. Nagy and R. J. Letcher (Submitted): Chlorinated hydrocarbon contaminants and metabolites in polar bears (Ursus maritimus) from Svalbard, East Greenland, Alaska and the canadian arctic during 1999−2002. Sci Total Environ. 17. Merkel, F. R., A. Mosbech, C. Sonne and A. Flagstad (In prep.): Local movements, habitat use, and survival of common eiders wintering in southwest Greenland. 18. Mosbech, A., G. Gilchrist, F. R. Merkel and C. Sonne (In prep.): Comparing spring and autumn migration of Arctic common eider based on satellite telemetry. 19. Mosbech, A., C. Sonne, A. Flagstad, P. L. Fast, M. Fast, F. R. Merkel and H. G. Gilchrist (In prep.): Behavioral and surgical effects of intracoelomic implantation of satellite transmitters in common eider (Somateria Molissima) and king eider (Somateria spectabiles), North East Canada 2001-2003. Reviewed scientific reports 2000-2003 1. Sonne-Hansen C., R. Dietz, P. S. Leifsson, L. Hyldstrup and F. F. Riget (2000): Cadmium toxicity to ringed seals (Phoca hispida). An epidemiological study of possible cadmium induced nephropathy and osteodystrophy in ringed seals (Phoca hispida) from Qaanaaq in Northwest 197
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National Environmental Research Ins
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National Environmental Research Ins
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Contents Summary 7 Resumé 11 Prefa
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Paper III-b Periodontitis and tooth
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Summary Marine mammals in the Arcti
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elations between histological chang
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Resumé Betydelige mængder svært
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signifikante relationer blev fundet
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Preface Since ca. 1960 signficant a
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Acquarone, Poul Johansen and Inge B
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Abbreviations ∑ Sum of congeners
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Introduction Study area and samplin
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content and composition) varying wi
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Of the PCBs found in the East Green
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son Bay bears while the difference
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Individual levels and biological ef
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No. skulls collected 50 45 40 35 30
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temperature extremes and/or food av
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Chapter 3 Bone mineral density and
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BMD analysed by DXA reflects the ar
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Table 4 Range in the levels (ng/g l
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Chapter 4 Liver histology of East G
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Table 7 Levels of ∑-PCBs, ∑-DDT
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Frequency (%) 100 80 60 40 20 Sever
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Effects of PBBs (PolyBrominated Bip
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Etiology and pathogenesis E Figure
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common sign (Acland 1995, Feldman 1
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Conclusions and final assessments O
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of CYP-450 activity that impact cir
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Regarding renal tissue, we will try
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Bernhoft, A., Ø. Wiig and J. U. Sk
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Feldman, E. C. (1995): Hyperadrenoc
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(eds.): Ringed seals in the North A
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McCormack, K. M., W. M. Kluwe, V. L
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Rosing-Asvid, A., E. W. Born and M.
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Valentino, R., S. Savastano, A. P.
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Paper I Seasonal and temporal trend
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eproductive rates of seals in the B
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concentrations of the 41 individual
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Figure 1 Capture locations of the p
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Table 4 Results of ANOVAs (F-value
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Long-Term Temporal Changes in OC Co
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Discussion Geographical Variation i
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sen et al. (2001) studied the trend
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higher than reported in other studi
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Bergman A, Olsson M. Pathology of b
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Muir D, Norstrom RJ. Geographical d
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Wiig Ø, Gjertz I, Hansson R, Thoma
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Key words: polar bear, Ursus mariti
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2. Materials and methods 2.1 Sampli
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2.3 Age Determination The age deter
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No. skulls collected 50 45 40 35 30
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Table 4 Results (test and p-values)
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Table 6 Results from F-tests (p-val
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(oxy-chlordane, trans-chlordane, ci
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Also Pertoldi et al. (1997) investi
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study could not document a relation
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Lie E, Bernhoft A, Riget FF, Beliko
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function in harbour seals (Phoca vi
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(p=0.94). Negative correlation betw
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Osteodensitometry X-ray osteodensit
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Figure 2 BMD (g cm 2 ) in skulls fr
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Table 3 Significant results from th
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2003) and plasma retinol and thyroi
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Comiso JC. 2002. A rapidly declinin
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Manalagas SC, Jilka RJ. 1995. Bone
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Valentine DW, Soulé M. 1973. Effec
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have the potential for adverse heal
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Dioxin-like contaminants Extraction
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Concentration 9000 8000 7000 6000 5
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Acknowledgements Danish Cooperation
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Polischuk, S. C., R. J. Letcher, R.
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Paper IV Liver histology of free-ra
Page 147 and 148: Histology All tissue samples were t
Page 149 and 150: Figure 1 Hepatic lipid accumulation
Page 151 and 152: Figure 2 Left: Portal mononuclear c
Page 153 and 154: Relationship between histology and
Page 155 and 156: kinson 1996). Due to these mechanis
Page 157 and 158: sues. Arctic Monitoring and Assessm
Page 159 and 160: van Duursen, M.B.M., Sanderson, J.
Page 161 and 162: Introduction Polar bears (Ursus mar
Page 163 and 164: Briefly, ∑PCBs is the sum (s) of
Page 165 and 166: Figure 1 Bottom: example of glomeru
Page 167 and 168: Figure 3 Tubular cell proliferation
Page 169 and 170: Hyalin casts Hyalin casts were eval
Page 171 and 172: Figure 6 Hyperemia (arrows) in the
Page 173 and 174: al., 2003). We did not find such a
Page 175 and 176: ANDERSEN, M., E. LIE, A. E. DEROCHE
Page 177 and 178: LUROSS, J. M., M. ALAEE, D. B. SERG
Page 179 and 180: organic mercury in liver and kidney
Page 181 and 182: Introduction Polar bears (Ursus mar
Page 183 and 184: Macroscopic examination of reproduc
Page 185 and 186: Results and discussion The female p
Page 187 and 188: SC II PC/LC Figure 2 The histology
Page 189 and 190: The relatively low levels of analys
Page 191 and 192: (Table 4), and we therefore conclud
Page 193 and 194: Acknowledgements Danish Cooperation
Page 195 and 196: Letcher RJ, Klasson-Wehler E, Bergm
Page 197: Swart RL, Ross PS, Vedder LJ, Timme
Page 201 and 202: crine organs and skulls in the East
Page 203: To investigate the relation between
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