Organohalogen concentrations and a gross and histologic ...

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194 O’Hara T, George JC, Tarpley RJ, Burek K and Suydam RS. Sexual maturation in male bowhead whales (Balaena mysticetus) of the Bering-Chukchi- Beaufort Seas stock. J Cetacean Res Manage 2002;4(2): 143-148. Oskam IC, Ropstad E, Dahl E, Lie E, Derocher AE, Wiig Ø, Larsen S, Wiger R and Skaare JU. Organochlorines affect the major androgenic hormone, testosterone, in male polar bears (Ursus maritimus) at Svalbard. J Toxicol Environ Health Part A 2003;66(22): 2119-2139. Oskam IC, Ropstad E, Dahl E, Lie E, Derocher AE, Wiig Ø, Larsen S, Wiger R and Skaare JU. Organochlorines affect the steroid hormone cortisol in polar bears (Ursus maritimus) at Svalbard, Norway. J Toxicol Environ Health Part A 2004;67: 959-977. Polani PE. Abnormal sex development in man. Anomalies of sexdifferentiating mechanisms (II). In: C. R. Austin and R. G. Edwards (eds.): Mechanisms of sex differentiation in animals and man (Vol. II). Academic Press, London, UK 1981: 467-547. Polischuk S, Ramsay M and Norstrom RJ. Body burdens and tissue concentrations of organochlorines in polar bears (Ursus maritimus ) vary during seasonal fasts. Environ Pollut 2002;118: 29-39. Rosing-Asvid A, Born EW, Kingsley MCS. Age at sexual maturity of males and timing of the mating season of polar bears (Ursus maritimus) in Greenland. Polar Biol 2002;25: 878-883. Sandala GM, Sonne C, Dietz R, Muir DCG, Valters K, Bennett ER, R.J. Letcher RJ. Methyl sulfone and hydroxylated PCB metabolites in adipose and whole blood of polar bear (Ursus maritimus) from Scoresby Sound, Greenland. Sci Total Environ 2004;331: 125-141. Sandau CD, Meerts IATM, Letcher RJ, McAlees AJ, Chittim B, Brouwer A, Norstrom RJ. Identification of 4-hydroxyheptachlorostyrene in polar bear plasma and its binding affinity to transthyretin: a metabolite of octachlorostyrene? Environ Sci Technol 2002;34: 3871-3877. Schandorff S. Developmental stability and skull lesions in the harbour seal (Phoca vitulina) in the 19 th and 20 th centuries. Ann. Zool. Fennici 1997a;34: 151- 166. Schandorff S. Developmental stability and the harbour seal epizootic in 1998. Ann Zool Fennici 1997b;34: 167-175. Singh S, Casper RF, Fritz PC, Sukhu B, Ganss B, Girard B, Savouret JF, Tenenbaum HC. Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol. J Endocrinol 2000 (1); 183-195. Skaare JU, Bernhoft A, Wiig O, Norum KR, Haug E, Eide DM, Derocher AE. Relationship between plasma levels of organochlorines, retinol and thyroid hormones from polar bears (Ursus maritimus) at Svalbard. J Toxicol Environ Health A 2001;62: 227-241. Sonne C, Dietz R, Leifsson PS, Born EW, Kirkegaard M, Riget FF, Letcher RJ, Muir DCG and Hyldstrup L. Liver histology of free-ranging polar bears (Ursus maritimus) from East Greenland. Toxicol Pathol Submitted-a. Sonne C, Dietz R, Leifsson PS, Born EW, Kirkegaard M, Riget FF, Letcher RJ, Muir DCG and Hyldstrup L. Renal lesions in East Greenland polar bears (Ursus maritimus) during 1999-2002. J Wildlife Dis Submitted-b. Sonne, C, Dietz, R, Born, EW, Riget, FF, Kirkegaard, M, Hyldstrup, L, Letcher, RJ and Muir, DCG. Is bone mineral composition disrupted by organochlorines in East Greenland polar bears (Ursus maritimus)?. Environ Hlth Persp Accepted with revision.
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National Environmental Research Ins
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National Environmental Research Ins
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Contents Summary 7 Resumé 11 Prefa
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Paper III-b Periodontitis and tooth
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Summary Marine mammals in the Arcti
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elations between histological chang
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Resumé Betydelige mængder svært
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signifikante relationer blev fundet
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Preface Since ca. 1960 signficant a
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Acquarone, Poul Johansen and Inge B
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Abbreviations ∑ Sum of congeners
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Introduction Study area and samplin
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content and composition) varying wi
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Of the PCBs found in the East Green
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son Bay bears while the difference
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Individual levels and biological ef
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No. skulls collected 50 45 40 35 30
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temperature extremes and/or food av
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Chapter 3 Bone mineral density and
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BMD analysed by DXA reflects the ar
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Table 4 Range in the levels (ng/g l
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Chapter 4 Liver histology of East G
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Table 7 Levels of ∑-PCBs, ∑-DDT
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Frequency (%) 100 80 60 40 20 Sever
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Effects of PBBs (PolyBrominated Bip
Page 51 and 52:
Etiology and pathogenesis E Figure
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common sign (Acland 1995, Feldman 1
Page 55 and 56:
Conclusions and final assessments O
Page 57 and 58:
of CYP-450 activity that impact cir
Page 59 and 60:
Regarding renal tissue, we will try
Page 61 and 62:
Bernhoft, A., Ø. Wiig and J. U. Sk
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Feldman, E. C. (1995): Hyperadrenoc
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(eds.): Ringed seals in the North A
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McCormack, K. M., W. M. Kluwe, V. L
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Rosing-Asvid, A., E. W. Born and M.
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Valentino, R., S. Savastano, A. P.
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Paper I Seasonal and temporal trend
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eproductive rates of seals in the B
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concentrations of the 41 individual
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Figure 1 Capture locations of the p
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Table 4 Results of ANOVAs (F-value
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Long-Term Temporal Changes in OC Co
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Discussion Geographical Variation i
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sen et al. (2001) studied the trend
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higher than reported in other studi
Page 91 and 92:
Bergman A, Olsson M. Pathology of b
Page 93 and 94:
Muir D, Norstrom RJ. Geographical d
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Wiig Ø, Gjertz I, Hansson R, Thoma
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Key words: polar bear, Ursus mariti
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2. Materials and methods 2.1 Sampli
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2.3 Age Determination The age deter
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No. skulls collected 50 45 40 35 30
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Table 4 Results (test and p-values)
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Table 6 Results from F-tests (p-val
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(oxy-chlordane, trans-chlordane, ci
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Also Pertoldi et al. (1997) investi
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study could not document a relation
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Lie E, Bernhoft A, Riget FF, Beliko
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function in harbour seals (Phoca vi
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(p=0.94). Negative correlation betw
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Osteodensitometry X-ray osteodensit
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Figure 2 BMD (g cm 2 ) in skulls fr
Page 125 and 126:
Table 3 Significant results from th
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2003) and plasma retinol and thyroi
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Comiso JC. 2002. A rapidly declinin
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Manalagas SC, Jilka RJ. 1995. Bone
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Valentine DW, Soulé M. 1973. Effec
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have the potential for adverse heal
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Dioxin-like contaminants Extraction
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Concentration 9000 8000 7000 6000 5
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Acknowledgements Danish Cooperation
Page 143 and 144:
Polischuk, S. C., R. J. Letcher, R.
Page 145 and 146: Paper IV Liver histology of free-ra
Page 147 and 148: Histology All tissue samples were t
Page 149 and 150: Figure 1 Hepatic lipid accumulation
Page 151 and 152: Figure 2 Left: Portal mononuclear c
Page 153 and 154: Relationship between histology and
Page 155 and 156: kinson 1996). Due to these mechanis
Page 157 and 158: sues. Arctic Monitoring and Assessm
Page 159 and 160: van Duursen, M.B.M., Sanderson, J.
Page 161 and 162: Introduction Polar bears (Ursus mar
Page 163 and 164: Briefly, ∑PCBs is the sum (s) of
Page 165 and 166: Figure 1 Bottom: example of glomeru
Page 167 and 168: Figure 3 Tubular cell proliferation
Page 169 and 170: Hyalin casts Hyalin casts were eval
Page 171 and 172: Figure 6 Hyperemia (arrows) in the
Page 173 and 174: al., 2003). We did not find such a
Page 175 and 176: ANDERSEN, M., E. LIE, A. E. DEROCHE
Page 177 and 178: LUROSS, J. M., M. ALAEE, D. B. SERG
Page 179 and 180: organic mercury in liver and kidney
Page 181 and 182: Introduction Polar bears (Ursus mar
Page 183 and 184: Macroscopic examination of reproduc
Page 185 and 186: Results and discussion The female p
Page 187 and 188: SC II PC/LC Figure 2 The histology
Page 189 and 190: The relatively low levels of analys
Page 191 and 192: (Table 4), and we therefore conclud
Page 193 and 194: Acknowledgements Danish Cooperation
Page 195: Letcher RJ, Klasson-Wehler E, Bergm
Page 199 and 200: 10. Heier, A., C. Sonne, A. Gröne,
Page 201 and 202: crine organs and skulls in the East
Page 203: To investigate the relation between
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