Organohalogen concentrations and a gross and histologic ...

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Table 1 Results of histological examination of liver tissue from 88 polar bears sampled in East Greenland, 1999-2002 given as frequencies (no. of observations in paranthesis). Changes considered were lipid content of Ito-cells (lipid), portal mononuclear cell infiltrations (infiltrations), lipid granulomes (granulomes), portal fibrosis (fibrosis) and bile duct proliferation (proliferation). Histopathological findings were classified according to severity (absent, mild and moderate). Sub: subadults of both sexes, AdF: adult females and AdM: adult males. In few cases of autolysis and freeze damage, one or more of the changes considered could not be evaluated. Group Lipid Infiltrations Granulomes Fibrosis Proliferation Absent 41% (14) Mild 26% (9) Moderate 32% (11) 148 Sub AdF AdM Sub AdF AdM Sub AdF AdM Sub AdF AdM Sub AdF AdM 10% (3) 10% (3) 80% (23) 0% (0) 16% (4) 84% (21) 3% (1) 66% (21) 31% (10) 8% (2) 72% (18) 20% (5) 21% (5) 16% (5) 54% (13) 68% (21) 25% (6) 16% (5) 52% (13) 36% (9) 12% (3) 33% (8) 54% (13) 13% (3) Mononuclear cell infiltrations and lipid granulomas The second histological change was focal, mainly portal, mononuclear cell infiltrations (lymphocytes, macrophages and neutrophils) and in few cases necrosis (eosinophilic bodies) of individual hepatocytes (chronic multifocal non-suppurativ hepatitis) (Fig. 2) and 1 case of fibrin exudation (focal acute hepatitis). In cases with heavy cell infiltrations these were randomly distributed (disseminated). The degree (absent, mild and moderate) of portal mononuclear cell infiltrations was not age-related (p>0.4), and did not differ between subadults and adults (p>0.4, Table 1). Additionally, granulomas were noted, and frequently containing a central vacuole (lipid granulom) although the vacuole could represent necrotic heaptocyte as well as lipid. Individual exhibiting moderate granuloma score were signficant older compared to individuals having mild granuloma score (p=0.005). There was a tendency – although not statistically significant - of subadults having a higher frequency of granulomas than adults (p
Figure 2 Left: Portal mononuclear cell infiltrations in a 3.5 year-old female polar bear (HE, 10x). Right: centroacinary lipid granulomas in a 16 year-old female East Greenland polar bear (same individual as in Fig. 1) (HE, 40x). Figure 3 Portal area of a 16-year-old female East Greenland polar bear (same individual as in Fig. 1). Arrows indicate mild bile duct proliferation (HE, 40x). Portal fibrosis and bile duct proliferation Portal fibrosis was correlated to age (p
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National Environmental Research Ins
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National Environmental Research Ins
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Contents Summary 7 Resumé 11 Prefa
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Paper III-b Periodontitis and tooth
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Summary Marine mammals in the Arcti
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elations between histological chang
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Resumé Betydelige mængder svært
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signifikante relationer blev fundet
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Preface Since ca. 1960 signficant a
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Acquarone, Poul Johansen and Inge B
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Abbreviations ∑ Sum of congeners
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Introduction Study area and samplin
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content and composition) varying wi
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Of the PCBs found in the East Green
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son Bay bears while the difference
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Individual levels and biological ef
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No. skulls collected 50 45 40 35 30
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temperature extremes and/or food av
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Chapter 3 Bone mineral density and
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BMD analysed by DXA reflects the ar
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Table 4 Range in the levels (ng/g l
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Chapter 4 Liver histology of East G
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Table 7 Levels of ∑-PCBs, ∑-DDT
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Frequency (%) 100 80 60 40 20 Sever
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Effects of PBBs (PolyBrominated Bip
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Etiology and pathogenesis E Figure
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common sign (Acland 1995, Feldman 1
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Conclusions and final assessments O
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of CYP-450 activity that impact cir
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Regarding renal tissue, we will try
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Bernhoft, A., Ø. Wiig and J. U. Sk
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Feldman, E. C. (1995): Hyperadrenoc
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(eds.): Ringed seals in the North A
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McCormack, K. M., W. M. Kluwe, V. L
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Rosing-Asvid, A., E. W. Born and M.
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Valentino, R., S. Savastano, A. P.
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Paper I Seasonal and temporal trend
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eproductive rates of seals in the B
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concentrations of the 41 individual
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Figure 1 Capture locations of the p
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Table 4 Results of ANOVAs (F-value
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Long-Term Temporal Changes in OC Co
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Discussion Geographical Variation i
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sen et al. (2001) studied the trend
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higher than reported in other studi
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Bergman A, Olsson M. Pathology of b
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Muir D, Norstrom RJ. Geographical d
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Wiig Ø, Gjertz I, Hansson R, Thoma
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Key words: polar bear, Ursus mariti
Page 99 and 100: 2. Materials and methods 2.1 Sampli
Page 101 and 102: 2.3 Age Determination The age deter
Page 103 and 104: No. skulls collected 50 45 40 35 30
Page 105 and 106: Table 4 Results (test and p-values)
Page 107 and 108: Table 6 Results from F-tests (p-val
Page 109 and 110: (oxy-chlordane, trans-chlordane, ci
Page 111 and 112: Also Pertoldi et al. (1997) investi
Page 113 and 114: study could not document a relation
Page 115 and 116: Lie E, Bernhoft A, Riget FF, Beliko
Page 117 and 118: function in harbour seals (Phoca vi
Page 119 and 120: (p=0.94). Negative correlation betw
Page 121 and 122: Osteodensitometry X-ray osteodensit
Page 123 and 124: Figure 2 BMD (g cm 2 ) in skulls fr
Page 125 and 126: Table 3 Significant results from th
Page 127 and 128: 2003) and plasma retinol and thyroi
Page 129 and 130: Comiso JC. 2002. A rapidly declinin
Page 131 and 132: Manalagas SC, Jilka RJ. 1995. Bone
Page 133 and 134: Valentine DW, Soulé M. 1973. Effec
Page 135 and 136: have the potential for adverse heal
Page 137 and 138: Dioxin-like contaminants Extraction
Page 139 and 140: Concentration 9000 8000 7000 6000 5
Page 141 and 142: Acknowledgements Danish Cooperation
Page 143 and 144: Polischuk, S. C., R. J. Letcher, R.
Page 145 and 146: Paper IV Liver histology of free-ra
Page 147 and 148: Histology All tissue samples were t
Page 149: Figure 1 Hepatic lipid accumulation
Page 153 and 154: Relationship between histology and
Page 155 and 156: kinson 1996). Due to these mechanis
Page 157 and 158: sues. Arctic Monitoring and Assessm
Page 159 and 160: van Duursen, M.B.M., Sanderson, J.
Page 161 and 162: Introduction Polar bears (Ursus mar
Page 163 and 164: Briefly, ∑PCBs is the sum (s) of
Page 165 and 166: Figure 1 Bottom: example of glomeru
Page 167 and 168: Figure 3 Tubular cell proliferation
Page 169 and 170: Hyalin casts Hyalin casts were eval
Page 171 and 172: Figure 6 Hyperemia (arrows) in the
Page 173 and 174: al., 2003). We did not find such a
Page 175 and 176: ANDERSEN, M., E. LIE, A. E. DEROCHE
Page 177 and 178: LUROSS, J. M., M. ALAEE, D. B. SERG
Page 179 and 180: organic mercury in liver and kidney
Page 181 and 182: Introduction Polar bears (Ursus mar
Page 183 and 184: Macroscopic examination of reproduc
Page 185 and 186: Results and discussion The female p
Page 187 and 188: SC II PC/LC Figure 2 The histology
Page 189 and 190: The relatively low levels of analys
Page 191 and 192: (Table 4), and we therefore conclud
Page 193 and 194: Acknowledgements Danish Cooperation
Page 195 and 196: Letcher RJ, Klasson-Wehler E, Bergm
Page 197 and 198: Swart RL, Ross PS, Vedder LJ, Timme
Page 199 and 200: 10. Heier, A., C. Sonne, A. Gröne,
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crine organs and skulls in the East
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To investigate the relation between
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