156 Messier, F., Taylor, M. K. <strong>and</strong> Ramsay, M. A. 1992. Seasonal activity patterns of female polar bears (Ursus maritimus) in the Canadian Arctic as revealed by satellite telemetry. Jour of Zool (London) 992(226), 219-229. Parkinson, A (1996): Biotransformation of xenobiotics. In: Klaassen, C. D. (editor): Casarett <strong>and</strong> Doull’s toxicology - the basic science of poisons. 5 th ed. McGraw-Hill Health Professions Division, New York, USA, pp. 113-186. Pol<strong>and</strong>, A. <strong>and</strong> Knutson, J. C. 1982. 2,3,7,8-tetrachlorodibenzo-p-dioxin <strong>and</strong> related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Ann Rev Pharmacol toxicol 22, 517-554. Prunescu, C. C., Serban-Parau, N., Brock, J. H., Vaughan, D. M. <strong>and</strong> Prunescu, P. 2003. Liver <strong>and</strong> kidney structure <strong>and</strong> iron content in romanian brown bears (Ursus arctos) before <strong>and</strong> after hibernation. Comp Biochem Phys A 134, 21-26. Ramsay, M. A. <strong>and</strong> Stirling, I. 1988. Reproductive biology <strong>and</strong> ecology of female polar bears (Ursus maritimus). Jour of Zool (London) 214, 601-634. Rawson, A. J., Patton, G. W., Hofmann, S., Pietra, G. G. <strong>and</strong> L. Johns. 1993. Liver abnormalities associated with chronic mercury accumulation in str<strong>and</strong>ed atlanctic bottlenose dolphins. Ecotox Environ Safe 25 41-47. Rosing-Asvid, A., Born, E. W. <strong>and</strong> Kingsley, M. C. S. 2002. Age at sexual maturity of males <strong>and</strong> timing of the mating season of polar bears (Ursus maritimus) in Greenl<strong>and</strong>. Polar Biol 25 878-883. S<strong>and</strong>ala G. M., Sonne, C., Dietz, R., Muir, D. C. G., Valters, K., Bennett, E. R., Letcher, R. J. 2004. Methyl sulfone <strong>and</strong> hydroxylated PCB metabolites in adipose <strong>and</strong> whole blood of polar bear (Ursus maritimus) from Scoresby Sound, Greenl<strong>and</strong>. Sci Total Environ 331 125-141. Sato, M., Miura, M., Kojima, N., Higashi, N., Imai, K., Sato, T., Wold, H. L., Moskaug, J. Ø., Blomhoff, R., Wake, K., Roos, N., Berg, T., Norum, T. R. <strong>and</strong> Senoo, H. 2001. Nuclear deviation in hepatic parenchymal cells on sinusoidal surfaces in arctic animals. Cell struct <strong>and</strong> funct 26 71-77. Schumacher, U., Zahler, S., Horny, H. P., Heidemann, G., Skirnisson, K. <strong>and</strong> Welsch, U. 1993. Histological investigations on the thyroid gl<strong>and</strong>s of marine mammals (Phoca vitulina, Phocoena phocoena) <strong>and</strong> the possible implications of marine pollution. J Wildlife Dis 29(1), 103-108. Senoo, H., Imail, K., Wake, K., Wold, H., Moskaug, J., Kojima, N., Matano, Y., Miura, M., Sato, M., Roos, N., Berg, T., Langvatn, R., Norum, K. <strong>and</strong> Blomhoff, R. 1999. Vitamin A-storing system in mammals <strong>and</strong> birds in an Arctic area – a study in the Svalbard Archipelago. In: Wiss, E., Knook, D. L., de Zanger, R. <strong>and</strong> Fraaser, R (eds.): Cells of the hepatic sinusoid. Vol. 7, Kupffer Cell Foundation, CE Leiden, The Netherl<strong>and</strong>s, pp. 34-35. Senoo, H., Imai, K., Higashi, N., Wake, K., Kojima, N., Miura, M., Wold, H., Moskaug, J., Sato, T., Sato, M., Roos, N., Berg, T., Norum, K. <strong>and</strong> Blomhoff, R. 2001. Transport <strong>and</strong> heptatic storage of vitamin A in arctic animals. In: Wiss, E., Knook, D. L., de Zanger, R. <strong>and</strong> Fraaser, R (eds.): Cells of the hepatic sinusoid. Vol. 8, Kupffer Cell Foundation, CE Leiden, The Netherl<strong>and</strong>s, pp. 207-209. Sonne, C., Dietz, R., Riget, F. F., Born, E. W., Kirkegaard, M., Hyldstrup, L., Letcher, R. <strong>and</strong> Muir, D. C. G. Accepted with revision. Is bone mineral composition disrupted by organochlorines in East Greenl<strong>and</strong> polar bears (Ursus maritimus)?. Environ Hlth Persp. Sonne C., Dietz, R., Leifsson, P. S., Riget, F. F., Born, E. W., Kirkegaard, M., Letcher, R. J., Muir, D. C. G. <strong>and</strong> Hyldstrup, L. Submitted. Renal lesions in East Greenl<strong>and</strong> polar bears (Ursus maritimus) during 1999-2002. Ambio.
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National Environmental Research Ins
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National Environmental Research Ins
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Contents Summary 7 Resumé 11 Prefa
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Paper III-b Periodontitis and tooth
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Summary Marine mammals in the Arcti
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elations between histological chang
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Resumé Betydelige mængder svært
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signifikante relationer blev fundet
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Preface Since ca. 1960 signficant a
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Acquarone, Poul Johansen and Inge B
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Abbreviations ∑ Sum of congeners
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Introduction Study area and samplin
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content and composition) varying wi
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Of the PCBs found in the East Green
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son Bay bears while the difference
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Individual levels and biological ef
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No. skulls collected 50 45 40 35 30
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temperature extremes and/or food av
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Chapter 3 Bone mineral density and
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BMD analysed by DXA reflects the ar
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Table 4 Range in the levels (ng/g l
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Chapter 4 Liver histology of East G
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Table 7 Levels of ∑-PCBs, ∑-DDT
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Frequency (%) 100 80 60 40 20 Sever
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Effects of PBBs (PolyBrominated Bip
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Etiology and pathogenesis E Figure
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common sign (Acland 1995, Feldman 1
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Conclusions and final assessments O
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of CYP-450 activity that impact cir
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Regarding renal tissue, we will try
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Bernhoft, A., Ø. Wiig and J. U. Sk
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Feldman, E. C. (1995): Hyperadrenoc
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(eds.): Ringed seals in the North A
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McCormack, K. M., W. M. Kluwe, V. L
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Rosing-Asvid, A., E. W. Born and M.
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Valentino, R., S. Savastano, A. P.
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Paper I Seasonal and temporal trend
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eproductive rates of seals in the B
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concentrations of the 41 individual
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Figure 1 Capture locations of the p
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Table 4 Results of ANOVAs (F-value
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Long-Term Temporal Changes in OC Co
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Discussion Geographical Variation i
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sen et al. (2001) studied the trend
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higher than reported in other studi
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Bergman A, Olsson M. Pathology of b
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Muir D, Norstrom RJ. Geographical d
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Wiig Ø, Gjertz I, Hansson R, Thoma
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Key words: polar bear, Ursus mariti
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2. Materials and methods 2.1 Sampli
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2.3 Age Determination The age deter
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No. skulls collected 50 45 40 35 30
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Table 4 Results (test and p-values)
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- Page 109 and 110: (oxy-chlordane, trans-chlordane, ci
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- Page 113 and 114: study could not document a relation
- Page 115 and 116: Lie E, Bernhoft A, Riget FF, Beliko
- Page 117 and 118: function in harbour seals (Phoca vi
- Page 119 and 120: (p=0.94). Negative correlation betw
- Page 121 and 122: Osteodensitometry X-ray osteodensit
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- Page 125 and 126: Table 3 Significant results from th
- Page 127 and 128: 2003) and plasma retinol and thyroi
- Page 129 and 130: Comiso JC. 2002. A rapidly declinin
- Page 131 and 132: Manalagas SC, Jilka RJ. 1995. Bone
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- Page 135 and 136: have the potential for adverse heal
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- Page 141 and 142: Acknowledgements Danish Cooperation
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- Page 145 and 146: Paper IV Liver histology of free-ra
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- Page 155 and 156: kinson 1996). Due to these mechanis
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- Page 161 and 162: Introduction Polar bears (Ursus mar
- Page 163 and 164: Briefly, ∑PCBs is the sum (s) of
- Page 165 and 166: Figure 1 Bottom: example of glomeru
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- Page 181 and 182: Introduction Polar bears (Ursus mar
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