Organohalogen concentrations and a gross and histologic ...

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112 Carrascal LM, Senar JC, Mozetich I, Uribe F and Domenech J. Interactions among environmental syress, body condition, nutritional status and dominance in great tits. AUK 1998; 115 (3): 727-38. Colborn TFS Vom Saal and Soto AM. Developmental effects of endocrinedisrupting chemicals in wildlife and humans. Environ. Hlth..Persp. 1993; 101: 378-84. Coy B. and C. Schaeff. Fluctuating asymmetry in california sea lions: a useful tool for assessing response to environmental stresses? International Conference on the biology of marine mammals, Vancouver, Canada november 28december 2 2001. Damstra T, Barlow S, Bergman A, Kavlock R and Kraak GVD. Global assessment of the state-of-the-science of endocrine disruptors. WHO, Geneva, Schwitzerland, 2002; 180 pp. de March BGE , de Wit C, Muir DCG, Braune B, Gregor DJ, Norstrom RJ, Olsson M, Skaare JU and Stange K. Chapter 6: Persistent Organic Pollutants. In: AMAP Assessment Report: Arctic Pollution Issues. Arctic Monitoring and Assessment Programme. Oslo, Norway 1998; 183-372. Dietz R, Riget FF, Sonne-Hansen C, Letcher RJ , Born EW and Muir DCG. Seasonal and temporal trends in Polychlorinated biphenyls and Organochlorine Pesticides in East Greenland polar bears (Ursus maritimus), 1990- 2001. Sci. Total Environ. 2004; 331: 107-24. Doyle WJ, Kelley C and Siegel M. The effects of audiogenic stress on the growth of long bones in laboratory rat (Rattus norvegicus). Growth 1977; 41: 183-89. Feldman EC. Hyperadrenocorticism. In: Ettinger, S. J. and E. C. Feldman (eds.): Textbook of veterinary internal medicine (vol. II). W.B. Saunders Company, Philadelphia, USA 1955; pp. 1538-78. Førland EJ, Hanssen-Bauer I, Jónsson T, Kern-Hansen C, Nordli PØ, Tveito OE, Vaarby Laursen E. Twentieth-century variations in temperature and precipitation in the Nordic Arctic. Polar Rec. 2002; 38(206): 203-10. Haave M, Ropstad E, Derocher AE, Lie E, Dahl E, Wiig Ø, Skaare JU and Jenssen BM. Polychlorinated biphenyls and reproductive hormones in female polar bears at Svalbard. Environ. Health Perspect. 2003; 111(4): 431-36. Hakk H and Letcher RJ. Metabolism in the toxicokinetics and fate of brominated flame retardants (BFRs)- A review. Environ. Internat. 2003; 29(6): 801-28. Jagoe CH and Haines TA. Fluctuating asymmetry in fishes inhabiting acidified and unacidified lakes. Can. J. of Zool. 1985; 63: 130-38. Jones JS. An asymmetrical view of fitness. Nature 1989; 325: 299. Koppe JG, Olie K, van Wijnen J. Placental transport of dioxins from mother to fetus. II PCBs, dioxins and furans and vitamin K metabolism. Dev. Pharmacol. Ther. 1992; 18: 9-13. Leary RF. and Allendorf FW. Fluctuating asymmetry as an indicator of stress: implications for conservation biology. Tree 1989; 4(7): 214-17. Letcher RJ, Norstrom RJ and Muir DCG. Biotransformation versus Bioaccumulation: Sources of Methyl Sulfone PCB and 4,4’-DDE Metabolites in the Polar Bear Food Chain. Environ. Sci. Technol. 1998; 32: 1656-61. Letcher RJ, van der Burg B, Brouwer A, Lemmen J, Bergman Å and van den Berg M. In vitro antiestrogenic effects of aryl methyl sulfone metabolites of polychlorinated biphenyls and 2,2-bis(4-chlorophenyl)-1,1-dichloroethene on 17β-estradiol-induced gene expression in several bioassay systems. Toxicol. Sci. 2002; 69: 362-72.
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National Environmental Research Ins
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National Environmental Research Ins
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Contents Summary 7 Resumé 11 Prefa
Page 7 and 8:
Paper III-b Periodontitis and tooth
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Summary Marine mammals in the Arcti
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elations between histological chang
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Resumé Betydelige mængder svært
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signifikante relationer blev fundet
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Preface Since ca. 1960 signficant a
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Acquarone, Poul Johansen and Inge B
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Abbreviations ∑ Sum of congeners
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Introduction Study area and samplin
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content and composition) varying wi
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Of the PCBs found in the East Green
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son Bay bears while the difference
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Individual levels and biological ef
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No. skulls collected 50 45 40 35 30
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temperature extremes and/or food av
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Chapter 3 Bone mineral density and
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BMD analysed by DXA reflects the ar
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Table 4 Range in the levels (ng/g l
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Chapter 4 Liver histology of East G
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Table 7 Levels of ∑-PCBs, ∑-DDT
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Frequency (%) 100 80 60 40 20 Sever
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Effects of PBBs (PolyBrominated Bip
Page 51 and 52:
Etiology and pathogenesis E Figure
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common sign (Acland 1995, Feldman 1
Page 55 and 56:
Conclusions and final assessments O
Page 57 and 58:
of CYP-450 activity that impact cir
Page 59 and 60:
Regarding renal tissue, we will try
Page 61 and 62:
Bernhoft, A., Ø. Wiig and J. U. Sk
Page 63 and 64: Feldman, E. C. (1995): Hyperadrenoc
Page 65 and 66: (eds.): Ringed seals in the North A
Page 67 and 68: McCormack, K. M., W. M. Kluwe, V. L
Page 69 and 70: Rosing-Asvid, A., E. W. Born and M.
Page 71 and 72: Valentino, R., S. Savastano, A. P.
Page 73 and 74: Paper I Seasonal and temporal trend
Page 75 and 76: eproductive rates of seals in the B
Page 77 and 78: concentrations of the 41 individual
Page 79 and 80: Figure 1 Capture locations of the p
Page 81 and 82: Table 4 Results of ANOVAs (F-value
Page 83 and 84: Long-Term Temporal Changes in OC Co
Page 85 and 86: Discussion Geographical Variation i
Page 87 and 88: sen et al. (2001) studied the trend
Page 89 and 90: higher than reported in other studi
Page 91 and 92: Bergman A, Olsson M. Pathology of b
Page 93 and 94: Muir D, Norstrom RJ. Geographical d
Page 95 and 96: Wiig Ø, Gjertz I, Hansson R, Thoma
Page 97 and 98: Key words: polar bear, Ursus mariti
Page 99 and 100: 2. Materials and methods 2.1 Sampli
Page 101 and 102: 2.3 Age Determination The age deter
Page 103 and 104: No. skulls collected 50 45 40 35 30
Page 105 and 106: Table 4 Results (test and p-values)
Page 107 and 108: Table 6 Results from F-tests (p-val
Page 109 and 110: (oxy-chlordane, trans-chlordane, ci
Page 111 and 112: Also Pertoldi et al. (1997) investi
Page 113: study could not document a relation
Page 117 and 118: function in harbour seals (Phoca vi
Page 119 and 120: (p=0.94). Negative correlation betw
Page 121 and 122: Osteodensitometry X-ray osteodensit
Page 123 and 124: Figure 2 BMD (g cm 2 ) in skulls fr
Page 125 and 126: Table 3 Significant results from th
Page 127 and 128: 2003) and plasma retinol and thyroi
Page 129 and 130: Comiso JC. 2002. A rapidly declinin
Page 131 and 132: Manalagas SC, Jilka RJ. 1995. Bone
Page 133 and 134: Valentine DW, Soulé M. 1973. Effec
Page 135 and 136: have the potential for adverse heal
Page 137 and 138: Dioxin-like contaminants Extraction
Page 139 and 140: Concentration 9000 8000 7000 6000 5
Page 141 and 142: Acknowledgements Danish Cooperation
Page 143 and 144: Polischuk, S. C., R. J. Letcher, R.
Page 145 and 146: Paper IV Liver histology of free-ra
Page 147 and 148: Histology All tissue samples were t
Page 149 and 150: Figure 1 Hepatic lipid accumulation
Page 151 and 152: Figure 2 Left: Portal mononuclear c
Page 153 and 154: Relationship between histology and
Page 155 and 156: kinson 1996). Due to these mechanis
Page 157 and 158: sues. Arctic Monitoring and Assessm
Page 159 and 160: van Duursen, M.B.M., Sanderson, J.
Page 161 and 162: Introduction Polar bears (Ursus mar
Page 163 and 164: Briefly, ∑PCBs is the sum (s) of
Page 165 and 166:
Figure 1 Bottom: example of glomeru
Page 167 and 168:
Figure 3 Tubular cell proliferation
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Hyalin casts Hyalin casts were eval
Page 171 and 172:
Figure 6 Hyperemia (arrows) in the
Page 173 and 174:
al., 2003). We did not find such a
Page 175 and 176:
ANDERSEN, M., E. LIE, A. E. DEROCHE
Page 177 and 178:
LUROSS, J. M., M. ALAEE, D. B. SERG
Page 179 and 180:
organic mercury in liver and kidney
Page 181 and 182:
Introduction Polar bears (Ursus mar
Page 183 and 184:
Macroscopic examination of reproduc
Page 185 and 186:
Results and discussion The female p
Page 187 and 188:
SC II PC/LC Figure 2 The histology
Page 189 and 190:
The relatively low levels of analys
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(Table 4), and we therefore conclud
Page 193 and 194:
Acknowledgements Danish Cooperation
Page 195 and 196:
Letcher RJ, Klasson-Wehler E, Bergm
Page 197 and 198:
Swart RL, Ross PS, Vedder LJ, Timme
Page 199 and 200:
10. Heier, A., C. Sonne, A. Gröne,
Page 201 and 202:
crine organs and skulls in the East
Page 203:
To investigate the relation between
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