Organohalogen concentrations and a gross and histologic ...

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16 Acknowledgements Rune Dietz gave me the opportunity to join arctic research in Greenland and preparing the present thesis. He came up with the idea, performed a significant job in the present investigation and gave me fruitful supervision. Without Rune this work would never had been a reality. My wife Pia Sonne and my children Sofie Sille Sonne and Oscar Lau Sonne are acknowledged for their patience with me, when I was writing ”day and night”. My parents, Pia and Ralph Sonne, introduced me to the Arctic world through several journeys in northern Scandinavia, from where I obtained my interest for this pristine environment. Erik W. Born is acknowled for his significant contributions to manuscripts and discussions along the route as well as his continous encouragement. Vibeke Dantzer is acknowledged for believing in me as a PhD student and for being my official supervisor and always taking time for me. Without you this education had never been a possibility for me. Pall Leifsson, Lars Hyldstrup and Frank F. Riget are acknowledged for being my external indispensable supervisors and Lise-Lotte W. Andersen for doing the genetic analysis on the female polar bear with clitoral enlargement and reference material. Maja Kirkegaard did a gigantic, technical support during the histology performance, skull measurements, age determination and for advice, discussions and comments on the thesis and are acknowledged for this. Rob J. Letcher and Derek C. G. Muir are acknowledged for conducting the contaminant analysis and for their fruitfull scientific cooperation and personal qualities. Local hunters, Jonas Brønlund, Hanne Tuborg and Birger Sandell are deeply acknowled for initiation and conduction of sample collection in the field. Without them the present study could not have been conducted. Steen Andersen, Foxtrot, provided photo collage, technical assistance at field sampling and necropsies for the present thesis and are acknowledged for this and his always enormous energy and our excellent friendship. Jeppe Møhl, Mogens Andersen, Abdi Hedayat and Hans Baagøe from the Zoological Museum in Copenhagen are acknowleged for access to the sampling and technical assistance in preparing bone material. Colleagues at the Department of Arctic Environment, National Environmental Research Institute, Roskilde, Copenhagen, Denmark are acknowledged for scientific discussions and high spirit. Technicians at the Laboratory of Pathology, Department of Veterinary Pathobiology, Royal Veterinary and Agricultural University, Denmark are acknowledged for conducting histology slides. Technicians at the Deparment of Endocrinology, University Hospital of Hvidovre, Denmark provided assistance during detection of the mineral density in skulls. Technicians at National Water Research Institute and Great Lakes Institute for Environmental Research, Canada are acknowledged for conducting the chemical analysis. Todd M O’Hara is acknowledged for disussions of histology and Professor Øystein Wiig and Professor Andy E. Derocher for fruitful discussions on presumed female pseudohermaphrodites at Svalbard. Aage K. Olsen, Mario
Acquarone, Poul Johansen and Inge Bro came up with usefull advice, discussions and comments on the thesis and are acknowledged for this. Hanne K. Petersen, former head of Department of Arctic Environment, is acknowledged for starting the financial puzzle. Furthermore, financial support was obtained from Danish Cooperation for Environment in the Arctic, The Commission for Scientific Research in Greenland, National Environmental Research Institute, Greenland Institute of Natural Resources and The Danish Research Agency. 17
Page 1 and 2: National Environmental Research Ins
Page 3 and 4: National Environmental Research Ins
Page 5 and 6: Contents Summary 7 Resumé 11 Prefa
Page 7 and 8: Paper III-b Periodontitis and tooth
Page 9 and 10: Summary Marine mammals in the Arcti
Page 11 and 12: elations between histological chang
Page 13 and 14: Resumé Betydelige mængder svært
Page 15 and 16: signifikante relationer blev fundet
Page 17: Preface Since ca. 1960 signficant a
Page 21 and 22: Abbreviations ∑ Sum of congeners
Page 23 and 24: Introduction Study area and samplin
Page 25 and 26: content and composition) varying wi
Page 27 and 28: Of the PCBs found in the East Green
Page 29 and 30: son Bay bears while the difference
Page 31 and 32: Individual levels and biological ef
Page 33 and 34: No. skulls collected 50 45 40 35 30
Page 35 and 36: temperature extremes and/or food av
Page 37 and 38: Chapter 3 Bone mineral density and
Page 39 and 40: BMD analysed by DXA reflects the ar
Page 41 and 42: Table 4 Range in the levels (ng/g l
Page 43 and 44: Chapter 4 Liver histology of East G
Page 45 and 46: Table 7 Levels of ∑-PCBs, ∑-DDT
Page 47 and 48: Frequency (%) 100 80 60 40 20 Sever
Page 49 and 50: Effects of PBBs (PolyBrominated Bip
Page 51 and 52: Etiology and pathogenesis E Figure
Page 53 and 54: common sign (Acland 1995, Feldman 1
Page 55 and 56: Conclusions and final assessments O
Page 57 and 58: of CYP-450 activity that impact cir
Page 59 and 60: Regarding renal tissue, we will try
Page 61 and 62: Bernhoft, A., Ø. Wiig and J. U. Sk
Page 63 and 64: Feldman, E. C. (1995): Hyperadrenoc
Page 65 and 66: (eds.): Ringed seals in the North A
Page 67 and 68: McCormack, K. M., W. M. Kluwe, V. L
Page 69 and 70:
Rosing-Asvid, A., E. W. Born and M.
Page 71 and 72:
Valentino, R., S. Savastano, A. P.
Page 73 and 74:
Paper I Seasonal and temporal trend
Page 75 and 76:
eproductive rates of seals in the B
Page 77 and 78:
concentrations of the 41 individual
Page 79 and 80:
Figure 1 Capture locations of the p
Page 81 and 82:
Table 4 Results of ANOVAs (F-value
Page 83 and 84:
Long-Term Temporal Changes in OC Co
Page 85 and 86:
Discussion Geographical Variation i
Page 87 and 88:
sen et al. (2001) studied the trend
Page 89 and 90:
higher than reported in other studi
Page 91 and 92:
Bergman A, Olsson M. Pathology of b
Page 93 and 94:
Muir D, Norstrom RJ. Geographical d
Page 95 and 96:
Wiig Ø, Gjertz I, Hansson R, Thoma
Page 97 and 98:
Key words: polar bear, Ursus mariti
Page 99 and 100:
2. Materials and methods 2.1 Sampli
Page 101 and 102:
2.3 Age Determination The age deter
Page 103 and 104:
No. skulls collected 50 45 40 35 30
Page 105 and 106:
Table 4 Results (test and p-values)
Page 107 and 108:
Table 6 Results from F-tests (p-val
Page 109 and 110:
(oxy-chlordane, trans-chlordane, ci
Page 111 and 112:
Also Pertoldi et al. (1997) investi
Page 113 and 114:
study could not document a relation
Page 115 and 116:
Lie E, Bernhoft A, Riget FF, Beliko
Page 117 and 118:
function in harbour seals (Phoca vi
Page 119 and 120:
(p=0.94). Negative correlation betw
Page 121 and 122:
Osteodensitometry X-ray osteodensit
Page 123 and 124:
Figure 2 BMD (g cm 2 ) in skulls fr
Page 125 and 126:
Table 3 Significant results from th
Page 127 and 128:
2003) and plasma retinol and thyroi
Page 129 and 130:
Comiso JC. 2002. A rapidly declinin
Page 131 and 132:
Manalagas SC, Jilka RJ. 1995. Bone
Page 133 and 134:
Valentine DW, Soulé M. 1973. Effec
Page 135 and 136:
have the potential for adverse heal
Page 137 and 138:
Dioxin-like contaminants Extraction
Page 139 and 140:
Concentration 9000 8000 7000 6000 5
Page 141 and 142:
Acknowledgements Danish Cooperation
Page 143 and 144:
Polischuk, S. C., R. J. Letcher, R.
Page 145 and 146:
Paper IV Liver histology of free-ra
Page 147 and 148:
Histology All tissue samples were t
Page 149 and 150:
Figure 1 Hepatic lipid accumulation
Page 151 and 152:
Figure 2 Left: Portal mononuclear c
Page 153 and 154:
Relationship between histology and
Page 155 and 156:
kinson 1996). Due to these mechanis
Page 157 and 158:
sues. Arctic Monitoring and Assessm
Page 159 and 160:
van Duursen, M.B.M., Sanderson, J.
Page 161 and 162:
Introduction Polar bears (Ursus mar
Page 163 and 164:
Briefly, ∑PCBs is the sum (s) of
Page 165 and 166:
Figure 1 Bottom: example of glomeru
Page 167 and 168:
Figure 3 Tubular cell proliferation
Page 169 and 170:
Hyalin casts Hyalin casts were eval
Page 171 and 172:
Figure 6 Hyperemia (arrows) in the
Page 173 and 174:
al., 2003). We did not find such a
Page 175 and 176:
ANDERSEN, M., E. LIE, A. E. DEROCHE
Page 177 and 178:
LUROSS, J. M., M. ALAEE, D. B. SERG
Page 179 and 180:
organic mercury in liver and kidney
Page 181 and 182:
Introduction Polar bears (Ursus mar
Page 183 and 184:
Macroscopic examination of reproduc
Page 185 and 186:
Results and discussion The female p
Page 187 and 188:
SC II PC/LC Figure 2 The histology
Page 189 and 190:
The relatively low levels of analys
Page 191 and 192:
(Table 4), and we therefore conclud
Page 193 and 194:
Acknowledgements Danish Cooperation
Page 195 and 196:
Letcher RJ, Klasson-Wehler E, Bergm
Page 197 and 198:
Swart RL, Ross PS, Vedder LJ, Timme
Page 199 and 200:
10. Heier, A., C. Sonne, A. Gröne,
Page 201 and 202:
crine organs and skulls in the East
Page 203:
To investigate the relation between
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