Organohalogen concentrations and a gross and histologic ...
Organohalogen concentrations and a gross and histologic ...
Organohalogen concentrations and a gross and histologic ...
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18<br />
Structure of this thesis<br />
This thesis is composed of an introduction that covers existing knowledge of<br />
organohalogens in relation to biological effects in the polar bear. This is followed<br />
by a description of levels, temporal <strong>and</strong> seasonal trends in organohalogens<br />
for 92 of the bears investigated in the present thesis <strong>and</strong> additional<br />
samples from 1990 (Paper I). Secondly, time trend analysis of skull<br />
fluctuating asymmetry <strong>and</strong> bone mineral density, which also deals with relations<br />
to individual levels of organohalogens, are reviewed (Paper II, III-a,b).<br />
The last part of the thesis describes the histology of liver, kidney, adrenals<br />
<strong>and</strong> reproductive organs in relation to individual levels of organohalogens<br />
(Paper IV, V, VI). Finally, over all conclusion, assessments, perspectives <strong>and</strong><br />
recommendations are proposed.<br />
List of publications <strong>and</strong> manuscripts included in the thesis<br />
Paper I: Dietz, R., F. F. Riget, C. Sonne, R. J. Letcher , E. W. Born <strong>and</strong> D.<br />
C. G. Muir (2004): Seasonal <strong>and</strong> temporal trends in Polychlorinated<br />
biphenyls <strong>and</strong> Organochlorine Pesticides in East Greenl<strong>and</strong><br />
polar bears (Ursus maritimus), 1990-2001. Sci Total Environ<br />
331: 107-124.<br />
Paper II: Sonne, C., F. F. Riget, R. Dietz, M. Kirkegaard, E. W. Born, R. J.<br />
Letcher <strong>and</strong> D. C. G. Muir (Submitted): Trends in fluctuating<br />
asymmetry in East Greenl<strong>and</strong> polar bears (Ursus maritimus)<br />
from 1892 to 2002 in relation to organohalogen pollution. Sci<br />
Total Environ.<br />
Paper III-a: Sonne, C., R. Dietz, E. W. Born, F. F. Riget, M. Kirkegaard, L.<br />
Hyldstrup, R. J. Letcher <strong>and</strong> D. C. G. Muir (Accepted with revision):<br />
Is bone mineral composition disrupted by organochlorines<br />
in East Greenl<strong>and</strong> polar bears (Ursus maritimus)?<br />
Environ Hlth Persp.<br />
Paper III-b: Sonne, C., R. Dietz, E. W. Born, M. Kirkegaard, F. F. Riget, R. J.<br />
Letcher <strong>and</strong> D. C. G. Muir (In prep.): Periodontitis <strong>and</strong> tooth<br />
wear in East Greenl<strong>and</strong> polar bears (Ursus maritimus) during<br />
1892-2002.<br />
Paper IV: Sonne, C., R. Dietz, P. S. Leifsson, E. W. Born, M. Kirkegaard,<br />
F. F. Riget, R. J. Letcher, D. C. G. Muir <strong>and</strong> L. Hyldstrup (Submitted):<br />
Liver histology of free-ranging polar bears (Ursus maritimus)<br />
from East Greenl<strong>and</strong>. Toxicol Pathol.<br />
Paper V: Sonne, C., R. Dietz, P. S. Leifsson, F. F. Riget, E. W. Born, M.<br />
Kirkegaard, R. J. Letcher, D. C. G. Muir <strong>and</strong> L. Hyldstrup<br />
(Submitted): Renal lesions in East Greenl<strong>and</strong> polar bears (Ursus<br />
maritimus) during 1999-2002. J Wildlife Dis.<br />
Paper VI: Sonne, C., P. S. Leifsson, R. Dietz, E. W. Born, R. J. Letcher, M.<br />
Kirkegaard, D. C. G. Muir, L. W. Andersen, F. F. Riget <strong>and</strong> L.<br />
Hyldstrup (In press): Enlarged clitoris in wild polar bears (Ursus<br />
maritimus) can be misdiagnosed as pseudohermaphroditism.<br />
Sci Total Environ.