Dubai Final-v20.indd - World Allergy Organization

ABstrACts
participated in this study. We measured urinary leukotrien E4 (U-ltE4) level under stable asthma condition, using Cayman’s EiA
kit after purification by HPlC, as we reported previously. AiA patients were classified into three groups, 1) patients with mild to
moderate asthma which was controlled at less than ginA step 3 treatment,2) patients with stable but severe asthma which was
well controlled at ginA step 4 treatment, and 3) patients with difficult-to-treat asthma which was not controlled at ginA step 4
treatment.
results: the AiA groups 1-3 showed median U-ltE4 concentrations 108, 259, and 582 pg/mg creatinine, respectively. there was no
significant difference between patients with mild to moderate asthma and healthy controls. On the other hand, the concentrations of
U-ltE4 in patients with severe but stable AiA patients and difficult-to-treat AiA patients significantly increased according to asthma
severity as compared with AiA patients with mild to moderate asthma.
Conclusion: Cyslt overproduction may be related to the asthma severity in AiA patients.
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CorrElaTion BETWEEn SPiromETrY rESUlTS anD BoDY maSS inDEX in PaTiEnTS WiTH aSTHma
Agondi, r. C. , Bisaccioni, C. , ribeiro, m. , Kalil, J. and giavina-Bianchi, P.
Clinical immunolgy and Allergy, sao Paulo University, sao Paulo, Brazil.
Background: studies have suggested that asthma in obese individuals differs from the classic asthma phenotype, presenting as
a disease that is more difficult to control and that does not respond as well to inhaled corticosteroids. the objective of the present
study was to determine whether obesity, age or a combination of the two are associated with abnormal spirometry results in
patients with asthma.
method: this was an observational, cross-sectional, retrospective study involving patients over 18 years of age who had been
diagnosed with asthma. We evaluated the results of spirometric tests conducted between February of 2009 and August of 2009.
the patients were classified in accordance with two criteria: body mass index (Bmi) and age.
results: We evaluated 453 patients and 453 corresponding sets of spirometry results. in the present study, the pulmonary function
parameters were negatively correlated with Bmi. in the obese group, the mean FEV value was 17.4% lower than that observed in
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the normal-weight group. Within that group, the number of abnormal spirometry results was significantly higher among the patients
≥ 60 years of age than among those 18-59 years of age. the proportion of females was also higher in the obese group.
Conclusion: Our results indicate that FEV and FVC decrease significantly in proportion to increases in Bmi and age. Because
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obesity is yet another factor that makes asthma control difficult, the weight of asthma patients should be closely monitored.
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PrEValEnCE oF BronCHial aSTHma anD iTS aSSoCiaTion WiTH SmoKing HaBiTS among aDUlT PoPUlaTion in rUral
arEa
Parasuramalu, B. g. 1 , Huliraj, n. 2 , B m, r. 1 , s P, P. K. 1 , Dr, g. 1 and n r, r. m. 1
1 2 Department of Community medicine, Kempegowda institute of medical sciences, Bangalore, india. Department of thoracic
medicine, Kempegowda institute of medical sciences, Bangalore, india.
Background: Only few studies have been conducted in rural areas in india to study the relationship of active tobacco smoking in
bronchial asthma. Hence the present study was conducted with the objectives: 1. to find out the prevalence of bronchial asthma. 2.
to find out the association between tobacco smoking and bronchial asthma. materials and methods: A cross sectional study was
conducted in the rural field practice area of Kempegowda institute of medical sciences, Bangalore. totally 3194 adult individuals
(18-70years) were selected from 30 villages (clusters) using cluster-sampling technique. On visiting each house, previously
validated and standardized translated Kannada version questionnaire was administered. individuals with symptoms suggestive of
asthma were subjected for clinical examination for the diagnosis of asthma. the data was compiled and analyzed. results: Among
the 3194 respondents, 1518 (47.5%) were males & 1676 (52.5%) were females. the prevalence of bronchial asthma was 2.88%.
the prevalence of asthma was higher among those reporting a history of current smoking. Among current smokers the number of
cigarettes/ bidis/ hookah smoked daily did not differ (p>0.05) between individuals without asthma and with asthma, whereas the
mean number of years of smoking did differ (p