Dubai Final-v20.indd - World Allergy Organization

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2. rAPiDCUts “a rapid fat burning catalyst”, to take 1 pack BiD, with ingredients in each pack including (i) magnolia bark extract
(known to contain turbocurarine) and (ii) caffeine 298mg (less than 400mg of caffeine per day from all sources, recommended by
Health Canada).
3. CHinA tUng sHUEH Pills “pill for blood thinning”, containing “radix salvine miltiorrhizae [sic]” with potential herb-drug
interaction with warfarin.
4. FU Zi li ZHOng WAn “nausea extract for gastric bloating”, containing prepared aconite root (Aconitum carmichaeli) with potential
adverse cardiac side effect.
Conclusions: there are potential adverse reactions in CAm and Ds purchased in Chinese herbal shops and health food stores in
north America. Physicians should inquire the use of CAm and Ds by patients. there should be higher standard in regulation in CAm
and Ds in north America.
2201
inTErim FinDingS From ESTaBliSHing THE EFFECTiVEnESS, CoST-EFFECTiVEnESS anD SaFETY oF oral anD
SUBlingUal immUnoTHEraPY For FooD allErgY: a SYSTEmaTiC rEViEW
nurmatov, U. 1 , Devereux, g. 2 and sheikh, A. 1
1Allergy & respiratory research group, Centre for Population Health sciences, the University of Edinburgh, Edinburgh, United
Kingdom. 2Department of Child Health, royal Aberdeen Children’s Hospital, the University of Aberdeen, Aberdeen, United Kingdom.
Background: the prevalence of food allergy in children has increased in recent decades. Oral and sublingual immunotherapy
aims to desensitise people and induce immunological tolerance, enabling igE-mediated food allergic patients to consume increased
quantities of the food(s) in question. this is a promising new therapeutic approach and a careful critique and synthesis of the
literature will be an important contribution towards establishing the safety, effectiveness and cost-effectiveness of this approach.
objectives: to identify and critically review the published and unpublished evidence for the effectiveness and safety of oral and
sublingual immunotherapy in people with igE-mediated food allergy.
methods: systematic review and meta-analysis of all interventional studies i.e. randomised controlled trials (rCts), quasi-rCts
and controlled clinical trials (CCts) were identified from searching 11 electronic databases. the primary outcomes of interest are
the recovery rate from food allergy as assessed by the ability to consume increased amount of the offending food allergen whilst
on treatment (i.e. desensitisation) and success rates for complete tolerance to the causative food. secondary outcomes of interest
include the frequency and severity of local/systematic adverse events, quality of life, health services use including emergency
department contacts and hospital admissions, and data on cost-effectiveness both from the perspectives of patients/families and
healthcare providers.
interim findings: Our searches identified 721 potentially relevant papers; after de-duplication, 626 potentially eligible papers were
included for screening. 606 studies were excluded for not meeting review criteria and another 20 potentially appropriate abstracts
reviewed, of which 11 satisfied our inclusion criteria. there were seven rCts and four CCts; nine of these trials relate to oral
immunotherapy and the remaining two are concerned with assessing sublingual therapy. Analyses are underway and results will be
presented at the conference.
implications: this work will clarify the evidence base for the use of oral and sublingual immunotherapy in people with igEmediated
food allergy and will inform national and international deliberations on service provision.
2202
CiSPlaTin aDminiSTraTion FolloWing aCUTE HYPErSEnSiTiViTY To oTHEr PlaTinUm ComPoUnDS: a PHaSE ii STUDY
syrigou, E. , makrilia, n. , Politi, K. , Kaklamanos, g. , manolopoulos, l. and syrigos, K. n.
Oncology Unit, 3rd Department of medicine, sotiria general Hospital, Athens school of medicine, greece, Athens, greece.
Platinum compounds are antineoplastic agents widely used in numerous malignancies. A high percentage of patients exhibit
carboplatin-associated hypersensitivity, especially after their seventh course of chemotherapy. the purpose of this study was to
determine how useful skin tests are in ruling out cross-reaction to cisplatin, especially when treating physicians wish to continue
platinum-based chemotherapy in patients responsive to these drugs. Prick tests were performed on three patients with medium
and severe hypersensitivity to carboplatin. these tests were followed by intradermal tests with a series of carboplatin and cisplatin
dilutions. Prick tests were negative for both carboplatin and cisplatin, whereas, in all patients, intradermal tests were positive with
carboplatin and negative with cisplatin. Cisplatin was administered instead of carboplatin and was well tolerated by all patients
without administering premedication. We reach the conclusion that intradermal skin tests can be used to detect cross-reaction
between platinum compounds in order that platinum-based therapy is safely continued with a different platinum agent. this method
requires neither desensitization nor premedication.
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