Dubai Final-v20.indd - World Allergy Organization

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Conclusion:sPlAD and FPigs, both rare forms of allergic diseases, coexisted in 5 infants. this leads to an idea that there may be
common factors concerning pathogenesis of those 2 conditions.
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THE PrEValEnCE oF CHilDHooD aSTHma, allErgiC rHiniTiS anD aToPiC DErmaTiTiS in YErEVan
gambarov, s. s. , Kostanyan, l. V. and Zakharyan, A.
Clinical immunology and Allergy, Yerevan state medical University after m. Heratsi, Yerevan, Armenia.
aim-the aim of this research was to explore the prevalence of childhood asthma, allergic rhinitis and atopic dermatitis via
standardized methods in Yerevan, which allow comparing our results with the international data.
methods- We have delivered standardized questionnaires of ‘the international study of Asthma and Allergies in Childhood’ (isAAC)
to 3079 parents of 6-7 years old pupils (73% response rate) and 3002 13-14 years old pupils (94% response rate) from a random
sample of 52 schools of Yerevan in october-december 2008. During the second phase we have also investigated the respiratory
function in the current wheezing group (98 and 105 pupils in 6-7 and 13-14 age groups respectively), transient wheezing group
(122 and 116) and control group (30 in each age group) with the use of portable spirometer and bronchial reversibility test (two
puffs of salbutamol àerosol were used to measure the reversibility).
results-the lifetime prevalence of wheezing was 9% in 6-7 years old children and 8.4% in 13-14 years old children. Current
wheezing (i.e. wheezing in past 12 months) was observed in 3.7% and 4% first and ninth grade schoolchildren, and self-reported
doctor diagnosed asthma was observed in 0.5 and 0.8% respectively.
in the younger age group the prevalence of lifetime rhinitis was 6.2%, current rhinitis-4.3%, and doctor diagnosed allergic
rhinitis-1%.For the older group the data were-11.7%, 8.5% and 1.9% respectively.
the prevalence of atopic eczema in the 6-7 old age group was 2.4% current eczema-1.4%, and diagnosed atopic eczema 0.6%. in
the older age group the lifetime prevalence of eczema was 4.4%, current eczema-3.2% and diagnosed atopic eczema-1.1%.
the spirometry results show that there is no statistically significant difference of forced expiratory volume in 1 second (FEV1)
between the wheezing and control groups, but the bronchial reversibility was statistically higher in wheezing group (both age
groups p=0.001 and p< 0.0005 for 6-7 and 13-14 age groups respectively).
Conclusion-Our data conclude that Yerevan is a region of low prevalence of asthma and other atopic disorders, but since the
prevalence of the symptoms of these diseases is several times higher than diagnosed diseases, we can conclude that allergies are
underdiagnosed in Yerevan.
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PrEVEnTaBlE imPaCT oF SUPlaTaST ToSilaTE DoSagE on aSTHma onSET in inFanTS
norifumi, O. 1 , norifumi, O. 2 , Kentaro, m. 3 , Hiroaki, O. 4 , Atsushi, i. 5 , Yutaka, K. 5 , toshiaki, s. 2 and takeshi, n. 2
1 2 3 Pediatrics, Chiba Aiyukai memorial Hospital, Chiba, Japan. Pediatrics, Kitasato University school of medicine, Japan.. Department
of Pediatrics, Chiba Aiyukai memorial Hospital, Chiba, Japan. 4Department of Pediatrics, tokyo Kousei-nenkin Hospital, Japan.
5Department of Pediatrics, Yokohama City minato red Cross Hospital, Japan.
Background: recent epidemiology suggests the increasing prevalence of allergic diseases including asthma in the industrialized
countries, which necessitates the analysis of the mechanisms of allergic diseases and development of the effective treatment.
suplatast tosilate (iPD) has been shown to be clinically effective for the treatment of hypersensitivity and childhood asthma, and it
is a novel antiallergic agent that suppresses several processes, including the synthesis of il-4 and il-5 in both human and murine
th2 cells. However, the effect of iPD to restrain the bronchial asthma onset of an infant having an established allergic factor has not
been examined. Hence influence on asthma onset by the iPD dosage in patients who repeated 1-3 times wheeze after the life that a
shift to the childhood asthma was observed.
Objective and methods: the object is 39 patients who accepted 1-3 times wheeze after birth ranging from 6 months to 3 years in
age. After an observation period of two weeks, they were divided into 3 groups; theophyline treated group (group A), theophyline +
iPD group (group B), and iPD alone (group C). the clinical evaluation was performed concerning frequency of coughing and wheeze,
and that of the β2-receptor agonist inhalation consumption in every four months with an asthma diary. in addition, allergic tests;
peripheral blood eosinophile count and serum igE value were determined in every four months.
results and Discussion: As for the coughing, the frequency fell not significantly 12 months later (the last four months) as compared
to the first four months in all groups. Concerning the wheeze, the significant decrease in particular was examined in group B, C. As
for the frequency of the β2-receptor agonist inhalation consumption, the significant decrease was observed in group B and C, but
not in group A. the meaningful change of the peripheral blood eosinophile count was not observed in group A and C. However it
increased 8 and 12 months later significantly in group B. the serum igE value increased 12 months later in group A and B, whereas
such a meaningful increase was never recognized in group C. iPD likely restrains an increase of serum igE value. Conclusion: iPD
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