Dubai Final-v20.indd - World Allergy Organization

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were significantly associated with eosinophilic infiltration rather than metastasis. Causes of eosinophilic infiltration were parasite
infection (n=15), drug (n=1) and undetermined (n=14).
Conclusion: Our results suggest that eosinophilic organ infiltration has distinguished clinical characteristics compared with
cancer metastasis. moreover, physicians need to have more efforts to find the causes of organ involvement with peripheral blood
eosinophilia, especially in cancer patients.
2103
oPPoSiTE EFFECT oF ETanErCEPT anD inFliXimaB on THE DEVEloPmEnT oF CUTanEoUS VaSCUliTiS
Kim, J.
Pediatrics, seoul national University College of medicine and rheumatology research institute, snU Hospital, seoul, south Korea.
We report here a case that showed opposite effect of two tnF-α antagonists, etanercept and infliximab, on cutaneous vasculitis
in a patient with JrA. three tnF-α antagonists, etanercept, infliximab, and adalimunmab are now available for the treatment of
JrA in Korea. As JrA is a chronic condition, increase of adverse effects by long-term use is a major obstacle in tnF-α antagonists
therapy. these include injection-site reaction, infusion-related reactions, infections, lymphoma, and lupus-like symptoms.
recently, development of cutaneous vasculitis has been observed in patients receiving tnF-α antagonists. We experienced
a JrA patient treated with etanercept(25~50mg/week) for 2 1/2 years developed cutaneous vasculitis on both of lower legs.
Pathological examination of skin biopsy revealed leukocytoclastic vasculitis. thus, etanercept therapy was discontinued due to
the extent and severity of vasculitis. After cessation of treatment for 4 months, the patient’s disease activity developed again and
infliximab(100mg/8weeks) was administered with remission of disease activity. Unexpectedly, however, we found that cutaneous
vasculitis was improved effectively by infliximab. this observation indicates that cutaneous vasculitis developed after introduction of
one tnF-α antagonist(etanercept) can be improved with administration of another tnF-α antagonist(infliximab) and suggests that
the opposite effect of these agents is probably associated with their ability to bind to tnF- α.
2104
BronCHoalVEolar laVagE anD SErUm EoSinoPHil CaTioniC ProTEin lEVElS in CHroniC aSTHma anD BronCHial
CarSinoma
Kose, s. 1 , Arici, m. 2 , Cavdar, g. 1 , Yavas, s. 1 and Camci, g. 1
1infectious Diseases and Clinical microbiology, Clinical Allergy and immunology, tepecik Educational and research Hospital, izmir,
turkey. 2Pulmonery Diseases, tepecik Educational and research Hospital, izmir, turkey.
inTroDUCTion
immunoglobuline E (igE) and eosinophil cationic protein (ECP) are important markers for atopy and allergic inflamation. Elevated
ECP levels may be found in the serum as well as the bronchoalveolar and nasopharyngeal secretions in many diseases, including
asthma, bronchiolitis and infections.
mETHoDS
the ECP in bronchoalveolar lavage fluid and in serum was measured in 15 patients with chronic pulmonary diseases such as
bronchial carsinoma (7 of patients) and asthma (8 of patients).
rESUlTS
ECP levels in BAl fluids were higher in the patients with asthma (mean ECP level : 1,75 mcg/l) than in the bronchial carsinoma
group (mean ECP level : 4 mcg/l). serum ECP levels ; were found 8,5 mcg/l in asthmatic group, and 3,4 mcg/l in patients with
bronchial carcinoma.
DiSCUSSion
in conclusion we can say that serum and BAl ECP levels are useful markers for predicting eosinophilic airways inflamation, and
serum ECP concentrations may be helpful noninvasive markers of atopic asthma.
2105
SUlFaTED moDiFiCaTion oF lYCiUm BarBarUm PolYSaCCHariDE UnDEr miCroWaVE irraDiaTion anD THEir anTi-HiV
aCTiViTiES
Zhu, X. and Zhang, H.
Beijing University of technology, Beijing, China.
the sulfated Lycium barbarum polysaccharide (lBP) were prepared by chlorosulfonic acid–pyridine (Py-sO ) method according to
3
orthogonal l (3) 9 4 test under microwave irradiation. Eight sulfated slBP, with various degrees of sulfate (Ds) and the number average
molecular weight (M ), were obtained and their anti-HiV activities were compared by mtt and ElisA assay. the results indicated
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