Dubai Final-v20.indd - World Allergy Organization

ABstrACts
ABstrACts
1213
ComBinaTion THEraPY For aSTHma: rESUlTS oF a DElPHi ProCESS
Price, D. 1 and Bousquet, J. 2
1 2 Centre of Academic Primary Care, University of Aberdeen, Aberdeen, United Kingdom. University of montpellier, montpellier, France.
Background. international guidelines recommend combination therapy with an inhaled corticosteroid (iCs) and a long-acting
β -agonist (lABA) as part of a stepped approach to asthma management, but do not provide guidance on how to choose specific
2
combinations. We report here the findings of an initiative undertaken under the auspices of the global Allergy and Asthma
European network (gA2lEn) to reach agreement on which factors are the most important to consider when choosing an iCs/lABA
combination for asthma.
methods. A Delphi process was used to elicit three rounds of structured feedback from a panel of European respiratory experts
from primary and secondary care who had a specialist research interest in the management of asthma. in round 1, panel members
recommended factors to consider using free text. responses were then coded and grouped for voting in round 2 using a 5-point
anchored likert scale (from 0 [not important] to 4 [very important]). the factors rated most important were included in statements
circulated to the panel, who then voted their level of agreement in round 3. Consensus was defined a priori as ≥ 66% agreement.
results. thirty-two experts from 9 European countries (Austria, Finland, France, germany, italy, spain, sweden, switzerland and
the UK) were invited to participate; response rates were 59.4% in round 1, 84.2% in round 2 and 84.2% in round 3. Fifteen factors
were identified through the free-text responses in round 1. nine of these were rated as important or very important by ≥ 75% of
the panel in round 2. in the final round, the panel reached consensus that the most important factors were: availability of a range of
doses; clinical efficacy of the combination and long-term safety and tolerability of the components; speed of onset of the lABA and
potency of the iCs.
Conclusion. in the absence of clear recommendations from international guidelines regarding the criteria that should inform the
selection of an iCs/lABA combination therapy for asthma, the results of this Delphi process may help to guide the evaluation and
assessment of these treatments.
1214
CorrElaTion BETWEEn aSTHma-rElaTED QUaliTY oF liFE anD aSTHma ConTrolS in aDUlT aSTHmaTiCS
Anıl, B. , Yıldız, P. , Aynacı, E. , Yıldırım, E. , Şahin, F. and seçik, F.
Pulmonology, Yedikule Chest Disease and surgery training and research Hospital, İstanbul, İstanbul, turkey.
Asthma has a multiface nature that results in a functional and emotional impairments.
Aim: the purpose of the present study was to evaluate relationship between the Asthma Control test (ACt), Asthma Control
Questionnaire (ACQ) and Asthma-related Quality of life Questionnaire (AQlQ) in adult asthmatics.
PAtiEnts AnD mEtHODs: 91 patients (72 female, 19 male; mean age 35.91 yrs) included in this prospective study. Patients were
followed-up for 3 months. they were completed the ACt and ACQ in order to assess disease control and AQlQ at 2 physician visits.
Pulmonary function was measured in each visit and asthma specialist rated asthma control and decided for treatment according to
the global initiative for Asthma (ginA) quideline.
rEsUlts: Uncontrolled patient ratio was 79% (72/91) before treatment. significant decreases to the 26 % (24/91) has been
shown with the 3 months asthma medication according to ginA guideline (p