Dubai Final-v20.indd - World Allergy Organization

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2203
FooD allErgY anD aToPiC DErmaTiTiS
Hekmatdoost, Jr., A.
Dep Clinical nutrition and Dietetics, shahid Beheshti University of medical sciences, tehran, iran.
Food allergy is one of the most important factor in children with atopic dermatitis (AD). in this study, we have measured any
association existed between AD severity, quality of life, total igE, eosinophil counts, and the number of food items sensitized.
specific igE of ten common food items was measured for a group of consecutive AD patients (n = 105) enrolled during a
randomized trial and correlated the findings with eczema severity. twenty-nine patients were negative for any of the ten common
food items. the most commonly sensitized foods were caw milk (51%), fish (49%), egg white (41%), and wheat (38%). Atopy to
beef as a protein and orange as a fruit were least common among the food items studied, even among patients positive for 8-9
igE items. Patients with severe AD (objective sCOrAD > 40) were more likely to be positive for at least one of the food items (Yates
corrected p = 0.024 for >/=1 food-specific igE in severe vs. moderate AD, Or 3.42 and 95% Ci 1.15-10.32); and for at least seven
of the food items (p = 0.001 for >/=7 food-specific igE vs. nil with Or 11.67 and 95% Ci 2.29-67.77), respectively. the spearman
coefficients between the number of positive food-specific igE and total sCOrAD, objective sCOrAD, area of AD involvement,
Children’s Dermatology life Quality index (CDlQi), total igE levels, and eosinophil counts were 0.42 (p < 0.001), 0.45 (p < 0.001),
0.50 (p < 0.001), 0.17 (p = 0.116), 0.80 (p < 0.001), and 0.22 (p = 0.043), respectively. specific igE levels for beef correlated with
all the other food-specific igE levels, including cow’s milk (rho = 0.061, p < 0.001) and soy (rho = 0.70, p < 0.001). the number of
common food items sensitized correlated with disease severity, extent, and total igE levels. it seems that many atopic children could
be treated by food limitations.
2204
CliniCal CHaraCTEriSTiCS oF raniTiDinE inDUCED HYPErSEnSiTiViTY
Cho, Y. J.
Allergy and Clinical immunology, internal medicine, Ewha Womans University mockdong Hospital, seoul, south Korea.
Purpose: ranitidine is a widely used drug for gastrointestinal problem and is usually associated with a low incidence of adverse
reactions. there have been only a few cases of immediate type hypersensitivity reactions to ranitidine. to see the characteristics of
ranitidine induced hypersensitivity, we analyzed 10 cases of ranitidine induced hypersensitive reaction
methods: Patient who is suspicious of ranitidine induced hypersensitivity was evaluated. skin test and oral provocation were
performed. We also evaluated the cross reactivity of other drugs (cimetidine, famotidine and proton pump inhibitor) used for gastric
protection.
results: Eighty percent of patient was positive in ranitidine skin test and oral provocation test. mean age of these patients was
35 ± 7 years old. male: female ratio was 4:6. two cases illustrates a severe anaphylactic reaction after a single intravenous dose
of 50 mgs of ranitidine and three cases showed anaphylactic reaction after oral intake of dose of 150mg of ranitidine. Five cases
illustrated only skin eruption after oral intake of 150mg of ranitidine. All of five cases who illustrated anaphylactic reaction showed
positive reaction with skin prick test and/or intradermal skin tests. three patients who showed only skin reactions were positive in
intradermal skin test with ranitidine. two of cases were negative for skin test with ranitidine and they showed mild skin eruption
with itching sense in 2 hours and 3 hours each with 75mg of ranitidine of oral provocation test. All of the 10 cases showed
negative reaction in skin test and oral provocation test with cimetidine, famotidine and proton pump inhibitor.
Conclusion: Our case suggests that ranitidine may induce immunoglobulin E-mediated anaphylaxis but also non-immunological
mechanisms may be involved in hypersensitivity reactions.
ranitidine may have very rare cross-reactivity with other gastric protective drugs. Clinicians should therefore be aware of possible
life-threatening adverse reactions to commonly used H2-receptor antagonists such as ranitidine.
2205
PangaSiUS HYPoPHTHalmUS HYPErSEnSiTiViTY
Palomeque, sr., m. t. 1 , torrecillas, m. 1 , Bartolome, B. 2 , martínez Borque, n. 1 , gonzález mendiola, m. r. 1 , martín Casáñez, E. 1 , lara
de la rosa, P. 1 , soto Vargas, g. 1 and martínez Bohigas, D. 1
1 2 Alergología, Complejo Hospitalario Universitario Albacete, Albacete, spain. Departamento i+D, Bial-Arístegui, Bilbao, spain.
introduction: Fish is a relatively common source of food allergens and its ingestion may cause fatal anaphylactic reactions. Fish
allergic subjects usually present igE antibody to several fish species, although clinical cross reactivity may be more limited. We
report a patient allergic to Pangasius hypophthalmus (Panga fish) but no to other fish. this exclusive sensitivity was confirmed by in
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